Protein Alignment HNF4A and Hnf4a

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_032287.2
• Gene: Hnf4a / 15378
• MGIID: 109128
• Length: 474
• Species: Mus musculus
• Alignment Length: 474
• Identity: 454/474 - (95%)
• Similarity: 460/474 - (97%)
• Gaps: 0/474 - (0%)

Human     1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGD 65
            |||||||..||||||||||||||||||||||||||||||||||||.|||:.||||||||||||||
Mouse     1 MRLSKTLAGMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGD 65

Human    66 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAV 130

Human   131 QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQL 195
            ||||||||||||||||||||||||||||||||:|||||:|||||||||||||:|.||||||||||
Mouse   131 QNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQL 195

Human   196 LVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAE 260
            ||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAE 260

Human   261 MSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYIND 325
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   261 MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYIND 325

Human   326 RQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLH 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||||
Mouse   326 RQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHTHHPLH 390

Human   391 PHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVAT 455
            |||||||||||||||||||:||||||||||||||||||||||||||||.|||||.|||||||:.|
Mouse   391 PHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITT 455

Human   456 IVKPLSAIPQPTITKQEVI 474
            ||||.||||||||||||.|
Mouse   456 IVKPPSAIPQPTITKQEAI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	74/74 (100%)
		NR_LBD_HNF4_like	151..373	CDD:132729	215/221 (97%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		25/27 (93%)
Hnf4a	NP_032287.2	NR_DBD_HNF4A	60..135	CDD:143518	74/74 (100%)
		NR_LBD_HNF4_like	151..373	CDD:132729	215/221 (97%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41235	368..376		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..450		34/36 (94%)