Protein Alignment HNF4A and hnf4a

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: XP_002933229.2
• Gene: hnf4a / 100492541
• XenbaseID: XB-GENE-482419
• Length: 466
• Species: Xenopus tropicalis
• Alignment Length: 475
• Identity: 390/475 - (82%)
• Similarity: 433/475 - (91%)
• Gaps: 12/475 - (2%)

Human     1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGD 65
            |||||.|:|||||||:.|||||||||||||:|||::|.|||||:.|:|||.||:||::|||||||
 Frog     3 MRLSKALIDMDMADYTEALDPAYTTLEFENMQVLSIGTDTSPSDVTSLNATNSIGVNSLCAICGD 67

Human    66 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    68 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAV 132

Human   131 QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQL 195
            |||||||||||||||||||||||.|:||||||:||||.|..:|.|||.||||||.|||:|||:||
 Frog   133 QNERDRISTRRSSYEDSSLPSINVLIQAEVLSQQITSSVGVLNTDIRGKKIASITDVCDSMKQQL 197

Human   196 LVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAE 260
            ||||||||||||||||||||||||||||||||||||||||||::||:||||||.::||:|||| |
 Frog   198 LVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNDRVIPRNCPEL-E 261

Human   261 MSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYIND 325
            :.||::|||||||||||||||||||||.|||||||||||||||||.||||:|.||||||||||||
 Frog   262 VGRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPTKIKRMRYQVQVSLEDYIND 326

Human   326 RQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLH 390
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||.::|||.|||||
 Frog   327 RQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLGGSANEAPHTHHPLH 391

Human   391 PHLMQEHMGTNVIVA-NTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVA 454
            |||:|:|:.|||||| ||:|:.|.||||          :||||||||||.|||:|.||::.||:|
 Frog   392 PHLVQDHLATNVIVANNTLPSQLHNGQM----------STPETPQPSPPAGSGAEQYKIVHGAIA 446

Human   455 TIVKPLSAIPQPTITKQEVI 474
            ::.|..::|||.||||||.:
 Frog   447 SVNKQPTSIPQSTITKQEAM 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	74/74 (100%)
		NR_LBD_HNF4_like	151..373	CDD:132729	192/221 (87%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		14/27 (52%)
hnf4a	XP_002933229.2	NR_DBD_HNF4A	62..137	CDD:143518	74/74 (100%)
		NR_LBD_HNF4_like	153..374	CDD:132729	192/221 (87%)