DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbh and dbh

DIOPT Version :9

Sequence 1:	NP_001284996.1	Gene:	Tbh / 31718	FlyBaseID:	FBgn0010329	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001103164.1	Gene:	dbh / 30505	ZFINID:	ZDB-GENE-990621-3	Length:	614	Species:	Danio rerio

Alignment Length:	610	Identity:	239/610 - (39%)
Similarity:	346/610 - (56%)	Gaps:	49/610 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TFMPVMLLLLMATLLTRPLSAFSNRLSDTKLHEIYLDDK-EIKLSWMVDWYKQEVLFHLQNAFNE 129
            |.|.:.:|..:..||.....|.:.:...|..:.|.||.. :::|||.:.:.|||||  |:....|
Zfish    14 TLMYLTVLATVVVLLVASYQAPAGQSRPTLAYHIPLDPSGQLELSWNISYPKQEVL--LEVKVKE 76

  Fly   130 QHRWFYLGFSKRGGLADAD--ICFFENQNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFKMDE--- 189
            .|....||.|.||...:||  |.:.:....:|.   |.::..:|: |..|.|||.::.:..:
Zfish    77 LHHGIILGMSDRGEPTNADLVILWDDGHKSYFG---DAWSDSEGR-VTLDTQQDYQLLETHQSTE 137

  Fly   190 -FTLAFRRKFDTCDPLDLRLHEGTMYVVWARGETELALEDHQFALPNVTAPHEAGVKMLQLLRAD 253
             |.|.|:|.|.||||.|..:.|||:::::...|..: |..|:..:..:    :.||:.:.|||
Zfish   138 GFFLLFKRSFSTCDPHDYIIEEGTVHIIYTMLEHPI-LSLHELNISRL----QPGVQRVLLLR-- 195

  Fly   254 KILIPETELDH-------MEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPG-- 309
                |:|...|       :|:...:..||:||||||||:.:|..|| .::|||.:|.:| |||
Zfish   196 ----PDTPSPHLPKDVRTLEVLAPDVIIPTQETTYWCHIYQLPPNL-PKNHIVMYESVI-TPGNE 254

  Fly   310 -IVHHMEVFHCEAGEHEEIPLYNGDCE-QLPPR-AKICSKVMVLWAMGAGTFTYPPEAGLPIGGP 371
             ||||:|||.| :.:.:.:|.|:|.|: ::.|| ...|..|:..|||||..|.||.:||||:||.
Zfish   255 AIVHHIEVFEC-SPQMDIVPQYSGSCDSKMKPRNLNYCRHVLAAWAMGAEPFYYPADAGLPMGGE 318

  Fly   372 GFNPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLS 436
            |.:.::|||||::||...||..|:||.|:..|.:||::||.:|||||.||..|||||.|.:|.|:
Zfish   319 GSSRFLRLEVHYHNPLLLSGRRDSSGIRLWYSPSLRRFDAGIMELGLVYTPVMAIPPRQRSFQLT 383

  Fly   437 GYCVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHY 501
            |||.|.||:.|||..||.||.|||||||.|:.|.|...||.||:..|..|.::|.|:|.:|.|..
Zfish   384 GYCTAKCTQTALPVGGIHIFASQLHTHLAGLGVRTVLVRGGQEVEVVQEDKHFSTHYQIIRVLQK 448

  Fly   502 KPRVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFI 566
            ...|||||||:|||.:||:|.....:|||.|.:||||||:||||.|:||:|||.|..:.|:.||.
Zfish   449 MVTVLPGDALLTTCRFNTEDRSKVTVGGFGIMEEMCVNYVHYYPRTQLELCKSHVDTDYLQKYFS 513

  Fly   567 YMKRTEHQHGVHL-NGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWE-- 628
            .:.|.:.:..... ..:....:.|:.|.....:.|.::|:..|.||.||:|....|.|  .||
Zfish   514 LINRFQGRESCSCPQTSVEEQFSSVSWDSFSGEVLNSLYVTAPFSMHCNQSTAQLFPG--DWEKQ 576

  Fly   629 GVAATPVQI-RIP----IHRKLCPN 648
            .:.....|: |.|    |:|::..|
Zfish   577 EIPVVTAQLQRAPYPCEINRRVASN 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbh	NP_001284996.1	DOMON	102..220	CDD:281361	41/124 (33%)
		Cu2_monooxygen	264..389	CDD:279429	61/136 (45%)
		Cu2_monoox_C	410..565	CDD:281675	86/154 (56%)
dbh	NP_001103164.1	DOMON	52..168	CDD:281361	40/121 (33%)
		Cu2_monooxygen	209..336	CDD:279429	60/129 (47%)
		Cu2_monoox_C	357..512	CDD:281675	86/154 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592015
Domainoid	1	1.000	185	1.000	Domainoid score	I3320
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H615
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1946
OMA	1	1.010	-	-		QHG45655
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0006061
OrthoInspector	1	1.000	-	-		oto41423
orthoMCL	1	0.900	-	-		OOG6_107941
Panther	1	1.100	-	-	LDO	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2835
SonicParanoid	1	1.000	-	-		X4984
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800