Protein Alignment Tbh and Dbh

DIOPT Version :10

• Sequence 1: NP_788884.1
• Gene: Tbh / 31718
• FlyBaseID: FBgn0010329
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_037290.3
• Gene: Dbh / 25699
• RGDID: 2489
• Length: 621
• Species: Rattus norvegicus
• Alignment Length: 600
• Identity: 222/600 - (37%)
• Similarity: 328/600 - (54%)
• Gaps: 44/600 - (7%)

  Fly    66 TFMPVMLLLLMATL--LTRPLSAFSNRLSDTKLHEIYLD-DKEIKLSWMVDWYKQEVLFHLQNAF 127
            |.:.:.|::|:|.|  ...|.|.|.        :.|.|| :..::|||.|. |.||:: |.|...
  Rat    27 TAVAIFLVILVAALQGSEPPESPFP--------YHIPLDPEGTLELSWNVS-YDQEII-HFQLQV 81

  Fly   128 NEQHRWFYLGFSKRGGLADADICFF--ENQNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFK---- 186
            .........|.|.||.:.:||:...  :....:|   .|.::...|| :..|..||.::.:
  Rat    82 QGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYF---ADAWSDQKGQ-IHLDTHQDYQLLQAQRV 142

  Fly   187 MDEFTLAFRRKFDTCDPLDLRLHEGTMYVVWARGETELALEDHQFALPNV-TAPHEAGVKMLQLL 250
            .:..:|.|:|.|.||||.|..:.:.|:::|:.      .||:...:|..: |:....|::.:|||
  Rat   143 SNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYG------ILEEPFQSLEAINTSGLHTGLQQVQLL 201

  Fly   251 RADKILIP--ETELDHMEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPG---I 310
            :.: :..|  ..::..|:|...:..|||.||||||::..|..:. .||||:.:|.:: |.|   :
  Rat   202 KPE-VSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHF-PRHHIIMYEAIV-TEGNEAL 263

  Fly   311 VHHMEVFHCEAGEHEEIPLYNGDCE--QLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGF 373
            |||||||.| ..|.|..|::||.|:  ..|.|...|..|:..||:||..|.||.|||:|.||.|.
  Rat   264 VHHMEVFQC-TNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPFGGSGS 327

  Fly   374 NPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGY 438
            :.::|||||::||....|..|:||.|:..:.:||..:|.:|||||.||..|||||.:|.|.|:||
  Rat   328 SRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGY 392

  Fly   439 CVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKP 503
            |...||:.|||.:||.||.|||||||.|.:|:|...|..|:...||||::||.||||:|.|....
  Rat   393 CTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAV 457

  Fly   504 RVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYM 568
            .|..||.|:|:|.|||::...|.:|||.|.:||||||:||||.|:||:|||:|.:..|:.||..:
  Rat   458 TVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIV 522

  Fly   569 KRTEHQHGVHLNGAR-SSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWEGVAA 632
            .|..::.......|. ...:.|:.|.....|.|..:|...|:|:.||::...||.|..:.:.:..
  Rat   523 NRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPK 587

  Fly   633 TPVQIRIPIHRKLCP 647
            ....:..|..|  ||
  Rat   588 ITSAVEEPDPR--CP 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbh	NP_788884.1	DOMON	106..219	CDD:460893	33/118 (28%)
		Cu2_monooxygen	265..390	CDD:460053	58/129 (45%)
		Cu2_monoox_C	409..565	CDD:461021	84/155 (54%)
Dbh	NP_037290.3	DOMON	62..175	CDD:460893	33/124 (27%)
		Cu2_monooxygen	217..340	CDD:460053	56/125 (45%)
		Cu2_monoox_C	363..519	CDD:461021	84/155 (54%)