Protein Alignment Tbh and tbh-1

DIOPT Version :9

• Sequence 1: NP_001284996.1
• Gene: Tbh / 31718
• FlyBaseID: FBgn0010329
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001257264.1
• Gene: tbh-1 / 181639
• WormBaseID: WBGene00006541
• Length: 657
• Species: Caenorhabditis elegans
• Alignment Length: 577
• Identity: 207/577 - (35%)
• Similarity: 311/577 - (53%)
• Gaps: 89/577 - (15%)

  Fly    98 EIYLDDKEIKLSWMVDWYKQEVLFHLQNAFNEQHRWF--------YLGFSKRGGLADADICFFEN 154
            |:|..:..:|  |..|:.:|.|.|.:         ||        :||||..|...::|:..:.|
 Worm    99 ELYHTNVTVK--WHTDYERQLVDFSI---------WFGASTPDVLFLGFSDFGDTNNSDVLMYYN 152

  Fly   155 QNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGT--MYVVW 217
            ..   ..:.|.||:.|.: :..|.|||.::.:..:..:..|||..|||..|.....||  .|:..
 Worm   153 SK---KEIKDAYTNRDFK-ITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAA 213

  Fly   218 ARGETELA-LEDHQFAL--------------PNV---TAPHEAGVKMLQLLRADKILIPETELDH 264
            :.|.|.|. :.|.::.:              ||:   .|..|..||:        :::.....|
 Worm   214 SWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKV--------VIVNSNSPD- 269

  Fly   265 MEITLQEAPIPSQETTYWCHVQRLE-GNLRRRHHIVQFEPLIRTPG---IVHHMEVFHCEAGEHE 325
                    |||:.||||.|.::::. ..:...:|:|:.||.: |||   :|||||:|.|    .:
 Worm   270 --------PIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYV-TPGNEHLVHHMEIFMC----RD 321

  Fly   326 EIPLYNGDCE--QLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEK 388
            |:..::|.|.  :.||::|.||.|:..||||.|...||.||||||||.|.|.||.:|:|:||||.
 Worm   322 EVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPEL 386

  Fly   389 QSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPATGI 453
            ..|::|:|||:..::..||:|||.:|||||.|:|..::||.|.|:.::|||.:.||: .||..||
 Worm   387 HKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTK-NLPEEGI 450

  Fly   454 IIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPGDALVTTCYYN 518
            .||.||||.||.|.::.|..:|....:.:||||::||.|:|.::.|....:|:|||.|||||.|:
 Worm   451 NIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYD 515

  Fly   519 TKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYMKRTEHQHGVHLNGAR 583
            |:.......||:.|.||||||||:||||:.:|||||::|..||..||      ..:||  ::|.|
 Worm   516 TRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYF------SERHG--MDGKR 572

  Fly   584 ---SSNYRSI-EWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFE-----GRSSWEGVA 631
               |..|.:: :|.....::.|.:.....::|.|.:|:|..||     .|.|||.:|
 Worm   573 MQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMA 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbh	NP_001284996.1	DOMON	102..220	CDD:281361	33/127 (26%)
		Cu2_monooxygen	264..389	CDD:279429	56/130 (43%)
		Cu2_monoox_C	410..565	CDD:281675	76/154 (49%)
tbh-1	NP_001257264.1	DOMON	102..215	CDD:281361	33/127 (26%)
		Cu2_monooxygen	270..387	CDD:279429	56/121 (46%)
		Cu2_monoox_C	408..562	CDD:281675	76/154 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164191
Domainoid	1	1.000	172	1.000	Domainoid score	I2247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H615
Inparanoid	1	1.050	336	1.000	Inparanoid score	I1411
Isobase	1	0.950	-	0	Normalized mean entropy	S4822
OMA	1	1.010	-	-		QHG45655
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0006061
OrthoInspector	1	1.000	-	-		oto20678
orthoMCL	1	0.900	-	-		OOG6_107941
Panther	1	1.100	-	-	LDO	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2835
SonicParanoid	1	1.000	-	-		X4984
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890