Protein Alignment Tbh and DBH

DIOPT Version :9

• Sequence 1: NP_001284996.1
• Gene: Tbh / 31718
• FlyBaseID: FBgn0010329
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_000778.3
• Gene: DBH / 1621
• HGNCID: 2689
• Length: 617
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 234/583 - (40%)
• Similarity: 330/583 - (56%)
• Gaps: 39/583 - (6%)

  Fly    63 RSPTFMPVMLLLLMATLLTRPLSAFSNRLSDTKLHEIYLD-DKEIKLSWMVDWYKQEVLFHLQNA 126
            |...||....:.:...:|...|...:.|.|....| |.|| :..::|||.|. |.||.: |.|..
Human    16 REAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH-IPLDPEGSLELSWNVS-YTQEAI-HFQLL 77

  Fly   127 FNEQHRWFYLGFSKRGGLADAD--ICFFENQNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFKM-- 187
            ..........|.|.||.|.:||  :.:.:....:|   .|.::...|| :..|.|||.::.::
Human    78 VRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYF---ADAWSDQKGQ-IHLDPQQDYQLLQVQR 138

  Fly   188 --DEFTLAFRRKFDTCDPLDLRLHEGTMYVVWARGETELALEDHQFALPNVTAPH-EAGVKMLQL 249
              :..||.|:|.|.||||.|..:.:||:::|:.      .||:...:|..:.... :.|::.:||
Human   139 TPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYG------ILEEPFRSLEAINGSGLQMGLQRVQL 197

  Fly   250 LRADKILIPETELDH----MEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPG- 309
            |:.:   |||.||..    ||:......||||||||||:::.|.... .||||:::||:: |.|
Human   198 LKPN---IPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGF-SRHHIIKYEPIV-TKGN 257

  Fly   310 --IVHHMEVFHCEAGEHEEIPLYNGDCE--QLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGG 370
              :|||||||.| |.|.:.:|.::|.|:  ..|.|...|..|:..||:||..|.||.||||..||
Human   258 EALVHHMEVFQC-APEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGG 321

  Fly   371 PGFNPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPL 435
            ||.:.|:|||||::||....|..|:||.|:..:..||:::|.:|||||.||..|||||.:|||.|
Human   322 PGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFIL 386

  Fly   436 SGYCVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLH 500
            :|||...||:.|||.:||.||.|||||||.|.:|:|...|..:|...||:|::||.||||:|.|.
Human   387 TGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLK 451

  Fly   501 YKPRVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYF 565
            ....|.|||.|:|:|.|||:|.:.|.:|||.|.:||||||:||||.|:||:|||:|....|:.||
Human   452 KVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYF 516

  Fly   566 IYMKRTEHQHGVHLNGAR-SSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSW 627
            ..:.|..::.......|. |..:.|:.|.....|.|..:|...|:||.||:|...||:|  .|
Human   517 HLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQG--EW 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbh	NP_001284996.1	DOMON	102..220	CDD:281361	38/124 (31%)
		Cu2_monooxygen	264..389	CDD:279429	61/133 (46%)
		Cu2_monoox_C	410..565	CDD:281675	86/154 (56%)
DBH	NP_000778.3	DOMON	57..172	CDD:281361	37/126 (29%)
		Cu2_monooxygen	213..337	CDD:279429	59/126 (47%)
		Cu2_monoox_C	362..516	CDD:281675	86/153 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..617

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156397
Domainoid	1	1.000	182	1.000	Domainoid score	I3471
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H615
Inparanoid	1	1.050	387	1.000	Inparanoid score	I2031
Isobase	1	0.950	-	0	Normalized mean entropy	S4822
OMA	1	1.010	-	-		QHG45655
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0006061
OrthoInspector	1	1.000	-	-		oto91355
orthoMCL	1	0.900	-	-		OOG6_107941
Panther	1	1.100	-	-	LDO	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2835
SonicParanoid	1	1.000	-	-		X4984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750