Protein Alignment Tbh and Dbh

DIOPT Version :9

• Sequence 1: NP_001284996.1
• Gene: Tbh / 31718
• FlyBaseID: FBgn0010329
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_620392.2
• Gene: Dbh / 13166
• MGIID: 94864
• Length: 622
• Species: Mus musculus
• Alignment Length: 600
• Identity: 235/600 - (39%)
• Similarity: 336/600 - (56%)
• Gaps: 44/600 - (7%)

  Fly    66 TFMPVMLLLLMATL--LTRPLSAFSNRLSDTKLHEIYLDDKEI-KLSWMVDWYKQEVLFHLQNAF 127
            |.:.:.|::|:|.|  ...|.|.|.        :.|.||.:.| :|||.|. |.||:: |.|...
Mouse    28 TAVAIFLVILVAALRGSEPPESPFP--------YHIPLDPEGILELSWNVS-YVQEII-HFQLQV 82

  Fly   128 NEQHRWFYLGFSKRGGLADADICFF--ENQNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFK---- 186
            .........|.|.||.:.:||:...  :....:|   .|.::...|| :..|.|||.::.:
Mouse    83 QGLRAGVLFGMSDRGEMENADLIMLWTDGDRAYF---ADAWSDRKGQ-IHLDSQQDYQLLQAQRT 143

  Fly   187 MDEFTLAFRRKFDTCDPLDLRLHEGTMYVVWARGETELALEDHQFALPNV-TAPHEAGVKMLQLL 250
            .|..:|.|:|.|.||||.|..:.:.|:::|:.      .||:...:|..: |:....|::.:|||
Mouse   144 RDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYG------ILEEPFQSLEAINTSGLHTGLQRVQLL 202

  Fly   251 RAD--KILIPETELDHMEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPG---I 310
            :::  ...:|| ::..|:|...:..||..||||||::..|.... .||||:.:|.:: |.|   :
Mouse   203 KSEVPTPSMPE-DVQTMDIRAPDILIPDNETTYWCYITELPPRF-PRHHIIMYEAIV-TEGNEAL 264

  Fly   311 VHHMEVFHCEAGEHEEIPLYNGDCE--QLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGF 373
            |||||||.| |.|.|:.|.:||.|:  ..|.|...|..|:..||:||..|.||.|||:|.||||.
Mouse   265 VHHMEVFQC-AAESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGS 328

  Fly   374 NPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGY 438
            :|::|||||::||.|..|..|:||.|:..:.|||:|||.:|||||.||..|||||.:|||.|:||
Mouse   329 SPFLRLEVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTGY 393

  Fly   439 CVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKP 503
            |...||:.||..:||.||.|||||||.|.:|:|...|..||.:.||||::||.||||:|.|....
Mouse   394 CTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQEIRMLKKVV 458

  Fly   504 RVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYM 568
            .|.|||.|:|:|.|||::...|.:|||.|.:||||||:||||.|:||:|||:|.:..|:.||..:
Mouse   459 TVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCKSAVDDGFLQKYFHMV 523

  Fly   569 KRTEHQHGVHLNGAR-SSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWEGVAA 632
            .|...:.......|. ...:.|:.|.....|.|..:|...|:||.||::...||.|..:.:.:..
Mouse   524 NRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPISMHCNKTSAVRFPGEWNLQPLPK 588

  Fly   633 TPVQIRIPIHRKLCP 647
            ....:..|..|  ||
Mouse   589 ITSTLEEPTPR--CP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbh	NP_001284996.1	DOMON	102..220	CDD:281361	37/124 (30%)
		Cu2_monooxygen	264..389	CDD:279429	60/129 (47%)
		Cu2_monoox_C	410..565	CDD:281675	87/154 (56%)
Dbh	NP_620392.2	DOMON	61..176	CDD:281361	36/126 (29%)
		Cu2_monooxygen	217..344	CDD:279429	60/129 (47%)
		Cu2_monoox_C	365..520	CDD:281675	87/154 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..622		3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846799
Domainoid	1	1.000	186	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H615
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2032
Isobase	1	0.950	-	0	Normalized mean entropy	S4822
OMA	1	1.010	-	-		QHG45655
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006061
OrthoInspector	1	1.000	-	-		oto94934
orthoMCL	1	0.900	-	-		OOG6_107941
Panther	1	1.100	-	-	LDO	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2835
SonicParanoid	1	1.000	-	-		X4984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740