DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sn and fscn2a

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001116988.1	Gene:	fscn2a / 798075	ZFINID:	ZDB-GENE-110901-1	Length:	488	Species:	Danio rerio

Alignment Length:	490	Identity:	205/490 - (41%)
Similarity:	298/490 - (60%)	Gaps:	23/490 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPSNTGESIIYLRSHLNKYLSVDQFGNVLCE 92
            ||||.:::|:|||.||||:||:|.|:||||:|||| .:....:::|||||.:|||.|:.|.|.||
Zfish    15 GLINHENRYLTAEAFGFKINASGNSMKKKQIWTLE-QDPDSQVVFLRSHLGRYLSSDKDGKVRCE 78

  Fly    93 SDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVNL 157
            .:..:...||.|.:..|  |||||::|....:.||:.:.|.|.|:|.|.||.|.:|||..||.||
Zfish    79 EEVPNTDCRFLIVMQSD--GRWALQSEPYLRYFGGSEEYLSCFAQTIGESELWALHLALHPQANL 141

  Fly   158 RSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVCN 222
            .|:.|||:||||..:|||.:|:|||||.|:|.||.:..   |:|:|.||:|::|..:|||.:...
Zfish   142 LSVARKRYAHLSTQEDEISMDSNIPWGVDSLITLVYLE---GKYSLKTCDNRFLKNDGKLVMEHG 203

  Fly   223 EDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGLNLR 286
            .:..|:.|...|.||.:|.:|:||||.|....||| |.:...:||||.||:|.||..|.|. |.|
Zfish   204 PNTSFTLELKSGKLAFKDCEGKYLSPNGPTGTLKSGRCTRPGKDELFDLEESHPQVVFQAA-NKR 267

  Fly   287 YVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADALF 351
            |||::  |.::||||:..:.||||:|.|....:...||....||.|...|||.::......:.:|
Zfish   268 YVSIR--VCISANQDDETDMETFQMEIDKETKKCMFRTNGGNYWTLVTHGGILSSATEIEENTMF 330

  Fly   352 ELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRTP 416
            ::.|.| ..::.:|:|||::.||::|.|.|.|:|:.|..:|...|||||||||:.|.|||.:...
Zfish   331 DIEWLG-RRIALKASNGKYVCTKKNGQLAAVSDSLGEDEQFVLKLINRPILVLRGENGFVCHHKN 394

  Fly   417 GNLKLECNKATYE--TILVERAQKGLVHLKAHSGKYWRIEGES-ISVDADAPSDGFFLELREPTR 478
            .| .|..:::.|:  |:|.   ..|...:|:.:.|:|.:.... :..|.|.|.| ||.|..|..|
Zfish   395 SN-TLHGSRSFYDIFTLLF---SDGGYQIKSGNQKFWYVSSSGLVCTDGDKPED-FFFEFVEYGR 454

  Fly   479 ICIRSQQGKYLGATKNGAFKLLDDG--TDSATQWE 511
            :.|::|.||||...:.|.  |:.||  .::::.||
Zfish   455 VGIKAQNGKYLRGDQGGT--LMGDGLSVNASSLWE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	53/113 (47%)
		Fascin	152..270	CDD:238160	55/118 (47%)
		Fascin	275..394	CDD:238160	44/118 (37%)
		Fascin	399..512	CDD:238160	40/118 (34%)
fscn2a	NP_001116988.1	Fascin	20..131	CDD:283843	53/113 (47%)
		Fascin	136..252	CDD:238160	55/118 (47%)
		Fascin	264..372	CDD:283843	40/111 (36%)
		Fascin	377..487	CDD:238160	38/116 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585545
Domainoid	1	1.000	114	1.000	Domainoid score	I6019
eggNOG	1	0.900	-	-		E1_2CMA3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22722
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1995
OMA	1	1.010	-	-		QHG52513
OrthoDB	1	1.010	-	-		D1419861at2759
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm24437
orthoMCL	1	0.900	-	-		OOG6_104023
Panther	1	1.100	-	-	O	PTHR10551
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770