DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sn and FSCN1

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_003079.1	Gene:	FSCN1 / 6624	HGNCID:	11148	Length:	493	Species:	Homo sapiens

Alignment Length:	491	Identity:	200/491 - (40%)
Similarity:	301/491 - (61%)	Gaps:	18/491 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLE--PSNTGESIIYLRSHLNKYLSVDQFGNVL 90
            ||||..:||:|||.||||:||:.:||||||:||||  |...|.:.:.|||||.:||:.|:.|||.
Human    15 GLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVT 79

  Fly    91 CESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQV 155
            ||.:......||.|...:|  |||:|::|:...:.|||.|:|.|.|:|...:|.|:||:|..|||
Human    80 CEREVPGPDCRFLIVAHDD--GRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQV 142

  Fly   156 NLRSIGRKRFAHLS-ESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQV 219
            |:.|:.|||:|||| ...|||.||.::|||.|:|.||.|:.:   ||::.|.::::|..:|:|..
Human   143 NIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQ---RYSVQTADHRFLRHDGRLVA 204

  Fly   220 VCNEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGL 283
            .......::.|:..|.:|.||.:|:||:|.|....||: :::.|.:||||:||.|..|. .:...
Human   205 RPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQV-VLQAA 268

  Fly   284 NLRYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCAD 348
            |.|.||.:||:|::|||||..:.||||||.|....:.|.||...:||.|:|.||:|:|.:.:.|.
Human   269 NERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNAS 333

  Fly   349 ALFELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGY 413
            ..|::.|. |..::.||:||||:.:|::|.|.|:.|:..:...|...||||||:|.:.|.||:|.
Human   334 CYFDIEWR-DRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGC 397

  Fly   414 R-TPGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGES-ISVDADAPSDGFFLELREP 476
            | ..|.  |:.|:::|:...:| ...|..::|..:||||.:..:| ::...|.|.| ||.|..:.
Human   398 RKVTGT--LDANRSSYDVFQLE-FNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVD-FFFEFCDY 458

  Fly   477 TRICIRSQQGKYLGATKNGAFKLLDDGTDSATQWEF 512
            .::.|: ..|:||.....|..|...:..|.|:.||:
Human   459 NKVAIK-VGGRYLKGDHAGVLKASAETVDPASLWEY 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	55/115 (48%)
		Fascin	152..270	CDD:238160	48/119 (40%)
		Fascin	275..394	CDD:238160	47/118 (40%)
		Fascin	399..512	CDD:238160	36/114 (32%)
FSCN1	NP_003079.1	Fascin	21..134	CDD:399343	55/114 (48%)
		Fascin	139..256	CDD:238160	48/119 (40%)
		Fascin	268..378	CDD:399343	46/110 (42%)
		Fascin	383..493	CDD:238160	36/114 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150925
Domainoid	1	1.000	114	1.000	Domainoid score	I6090
eggNOG	1	0.900	-	-		E1_2CMA3
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2228
Isobase	1	0.950	-	0	Normalized mean entropy	S6526
OMA	1	1.010	-	-		QHG52513
OrthoDB	1	1.010	-	-		D1419861at2759
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm41025
orthoMCL	1	0.900	-	-		OOG6_104023
Panther	1	1.100	-	-	LDO	PTHR10551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4757
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750