DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sn and fscn2b

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_957064.2	Gene:	fscn2b / 393743	ZFINID:	ZDB-GENE-040426-1740	Length:	490	Species:	Danio rerio

Alignment Length:	487	Identity:	206/487 - (42%)
Similarity:	297/487 - (60%)	Gaps:	12/487 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPSNTGESIIYLRSHLNKYLSVDQFGNVLCE 92
            ||||.:::|:|||.||||:||:..||||||:||||..:....::||||||.:||:.|:.|.|.||
Zfish    14 GLINHENRYLTAEAFGFKVNASAPSLKKKQIWTLEQDDQDGQVVYLRSHLGRYLASDKDGKVSCE 78

  Fly    93 SDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVNL 157
            ::.::...||.|....|  |||||::|:...|.||:.|.|.|.|:|.|.:|.|.:|||..||.||
Zfish    79 AETKENDCRFLIVAQSD--GRWALQSETYLRFFGGSEDYLSCFAQTIGEAELWAMHLALHPQANL 141

  Fly   158 RSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVCN 222
            .|:.|||:|||:..:.||.||.|||||.|.|.||.:.   .|:|.|.|.::::|:.:|||.....
Zfish   142 LSVARKRYAHLASPEGEIAVDCNIPWGVDALLTLVYM---DGKYCLKTSDSRFLSNDGKLSSENG 203

  Fly   223 EDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGLNLR 286
            ....::.|...|.||.:|.:|:||:|:|....|:| |.|...:||||.||:|.||..|.|. |.|
Zfish   204 RGTGYTLELKSGKLAFKDCEGKYLTPMGPTGTLRSGRCSKPGKDELFDLEESHPQVVFQAA-NNR 267

  Fly   287 YVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADALF 351
            :||::|||.|:||||:..:.||||:|.|....:...||.:..||.|.|.||||:|.....|:.:|
Zfish   268 FVSIRQGVSVSANQDDETDMETFQMEIDKDTRKCKFRTNEGNYWTLVAHGGIQSTATEAGANTMF 332

  Fly   352 ELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRTP 416
            :::|.| ..::.||:|||::.||::|.|.|.|:|:.|..:....|||||||:|:.|.|:|.:...
Zfish   333 DIVWLG-RRVALRASNGKYVCTKKNGQLSAVSDSVGEDEQLILKLINRPILILRGENGYVCHHKN 396

  Fly   417 GNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGE-SISVDADAPSDGFFLELREPTRIC 480
            .| .|:.:::.|: |...:...|..|:|...||:|.:... .:..|.|.|.| |..|..|..||.
Zfish   397 SN-TLDASRSVYD-IFTLQFSDGAYHIKGAGGKFWYVSSSGXVCSDGDTPED-FSFEFLEHGRIA 458

  Fly   481 IRSQQGKYLGATKNGAFKLLDDGTDSATQWEF 512
            ||.:.||||...:.|..|...:..||::.||:
Zfish   459 IRGKNGKYLRGDQGGNLKGDGETADSSSLWEY 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	54/113 (48%)
		Fascin	152..270	CDD:238160	50/118 (42%)
		Fascin	275..394	CDD:238160	50/118 (42%)
		Fascin	399..512	CDD:238160	38/113 (34%)
fscn2b	NP_957064.2	Fascin	19..131	CDD:283843	54/113 (48%)
		Fascin	136..252	CDD:238160	50/118 (42%)
		Fascin	264..370	CDD:283843	46/107 (43%)
		Fascin	379..490	CDD:238160	38/113 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585546
Domainoid	1	1.000	114	1.000	Domainoid score	I6019
eggNOG	1	0.900	-	-		E1_2CMA3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22722
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1995
OMA	1	1.010	-	-		QHG52513
OrthoDB	1	1.010	-	-		D1419861at2759
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm24437
orthoMCL	1	0.900	-	-		OOG6_104023
Panther	1	1.100	-	-	O	PTHR10551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4757
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800