DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sn and Fscn2

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001100542.1	Gene:	Fscn2 / 303741	RGDID:	1308941	Length:	492	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	194/491 - (39%)
Similarity:	287/491 - (58%)	Gaps:	19/491 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPS-NTGESIIYLRSHLNKYLSVDQFGNVLC 91
            ||:|...:|:|||:||||:||:.||||:||:|.|||. ..|.::::..|||.:|||.::.|.|.|
  Rat    15 GLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVAC 79

  Fly    92 ESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVN 156
            |.|......||.:....|  |||.|::|..|.|.||..|:|.|.|.....:|.||||||..||.:
  Rat    80 EMDHPGRDCRFLVLPQPD--GRWVLQSEPHGRFFGGVEDRLSCFATAISPAELWTVHLAIHPQAH 142

  Fly   157 LRSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVC 221
            |.|:.|:|:.||...:||:..|.::|||.|.|.||.|::.   ||.|.:.:::||.::|:|....
  Rat   143 LLSVSRRRYVHLCLQEDEMAADGDMPWGVDALLTLIFQSR---RYCLKSYDSRYLRSDGRLVWEP 204

  Fly   222 NEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGLNL 285
            .....::.|:..|.||.:|..|:||:|:|....||: |::...:||||.||.|.||...:|. |.
  Rat   205 EAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPGKDELFDLEQSHPQVVLVAA-NH 268

  Fly   286 RYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADAL 350
            |||||:||::|:|||||..::|||.::.|....:....::...||.|...||||||..:..|:.:
  Rat   269 RYVSVRQGINVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTM 333

  Fly   351 FELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRT 415
            ||:.||| ..::.:|:||:::..|::|.|.|.|:.:.|...|...|||||||||:...|||.:|.
  Rat   334 FEIEWHG-RRVALKASNGRYVCMKKNGQLAAISDFVGEDELFILKLINRPILVLRGLDGFVCHRR 397

  Fly   416 PGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGE-SISVDADAPSDGFFLELREPTRI 479
             |:.:|:.|::||:...:. .:.|...::...|.:|..... |:..|.|...| |..|.||..|:
  Rat   398 -GSNQLDTNRSTYDVFHLS-FRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAED-FLFEFRERGRL 459

  Fly   480 CIRSQQGKYLGATKNGAFKLLDDGTDSAT---QWEF 512
            .||:..||||   :.||..||....|..|   .||:
  Rat   460 AIRALSGKYL---RGGASGLLRADADLPTGEALWEY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	50/114 (44%)
		Fascin	152..270	CDD:238160	43/118 (36%)
		Fascin	275..394	CDD:238160	46/118 (39%)
		Fascin	399..512	CDD:238160	40/116 (34%)
Fscn2	NP_001100542.1	Fascin	20..133	CDD:399343	50/114 (44%)
		Fascin	138..254	CDD:238160	43/118 (36%)
		Fascin	266..376	CDD:399343	43/111 (39%)
		Fascin	381..492	CDD:238160	40/116 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344459
Domainoid	1	1.000	114	1.000	Domainoid score	I5927
eggNOG	1	0.900	-	-		E1_2CMA3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22722
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2152
OMA	1	1.010	-	-		QHG52513
OrthoDB	1	1.010	-	-		D1419861at2759
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm45161
orthoMCL	1	0.900	-	-		OOG6_104023
Panther	1	1.100	-	-	O	PTHR10551
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770