DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sn and FSCN2

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001070650.1	Gene:	FSCN2 / 25794	HGNCID:	3960	Length:	516	Species:	Homo sapiens

Alignment Length:	512	Identity:	187/512 - (36%)
Similarity:	286/512 - (55%)	Gaps:	37/512 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPS-NTGESIIYLRSHLNKYLSVDQFGNVLC 91
            ||:|...:|:|||:||||:||:..|||:||.|.|||. ..|.:::...|||.:|||.::.|.|.|
Human    15 GLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGQGTAVLLRSSHLGRYLSAEEDGRVAC 79

  Fly    92 ESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVN 156
            |:::.....||.:....|  |||.|::|..|.|.|||.|:|.|.|.....:|.||||||..||.:
Human    80 EAEQPGRDCRFLVLPQPD--GRWVLRSEPHGRFFGGTEDQLSCFATAVSPAELWTVHLAIHPQAH 142

  Fly   157 LRSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVC 221
            |.|:.|:|:.||...:||:..|.:.|||.|.|.||.||:.   ||.|.:|:::||.::|:|....
Human   143 LLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSR---RYCLKSCDSRYLRSDGRLVWEP 204

  Fly   222 NEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGLNL 285
            .....::.|:..|.||.:|..|.||:|:|....||: |::...:||||.||:|.||...:|. |.
Human   205 EPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEESHPQVVLVAA-NH 268

  Fly   286 RYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADAL 350
            |||||:|||:|:||||:..::|||.::.|....:....::...||.|...|||.||..:..|:.:
Human   269 RYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIHATATQVSANTM 333

  Fly   351 FELIWHGDGSLSFRANNGKFLATKRSGHLFATSESI---------EEIA---------------K 391
            ||:.|.| ..::.:|:||:::..|::|.|.|.|:.:         .::|               :
Human   334 FEMEWRG-RRVALKASNGRYVCMKKNGQLAAISDFVGPPPRPAWTGKVAGGAAQQTLSPPGKDEE 397

  Fly   392 FYFYLINRPILVLKCEQGFVGYRTPGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGE 456
            |...|||||||||:...|||.:.. |:.:|:.|::.|:...:..:. |...::...|.:| ..|.
Human   398 FTLKLINRPILVLRGLDGFVCHHR-GSNQLDTNRSVYDVFHLSFSD-GAYRIRGRDGGFW-YTGS 459

  Fly   457 SISVDADAP-SDGFFLELREPTRICIRSQQGKYLGATKNGAFKLLDDGTDSATQWEF 512
            ..||.:|.. ::.|..|.||..|:.||::.||||....:|..:...|.......||:
Human   460 HGSVCSDGERAEDFVFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGTALWEY 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	49/114 (43%)
		Fascin	152..270	CDD:238160	45/118 (38%)
		Fascin	275..394	CDD:238160	44/142 (31%)
		Fascin	399..512	CDD:238160	34/113 (30%)
FSCN2	NP_001070650.1	Fascin	21..133	CDD:283843	49/113 (43%)
		Fascin	138..254	CDD:238160	45/118 (38%)
		Fascin	266..370	CDD:283843	39/105 (37%)
		Fascin	414..516	CDD:283843	28/104 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150924
Domainoid	1	1.000	114	1.000	Domainoid score	I6090
eggNOG	1	0.900	-	-		E1_2CMA3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22722
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2228
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52513
OrthoDB	1	1.010	-	-		D1419861at2759
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm41025
orthoMCL	1	0.900	-	-		OOG6_104023
Panther	1	1.100	-	-	O	PTHR10551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4757
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800