DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sn and fscn2

DIOPT Version :9

Sequence 1:	NP_001162697.1	Gene:	sn / 31717	FlyBaseID:	FBgn0003447	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001093724.1	Gene:	fscn2 / 100101745	XenbaseID:	XB-GENE-494827	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	488	Identity:	205/488 - (42%)
Similarity:	303/488 - (62%)	Gaps:	13/488 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPSNTGESIIYLRS-HLNKYLSVDQFGNVLC 91
            ||||..::|:|.|.||||:.|...||||||:||||......|::||:| ||.:|||.|:.|||.|
Frog    15 GLINCDNRYLTGEAFGFKVYATAPSLKKKQIWTLEQDQVDSSVVYLKSHHLARYLSADKDGNVSC 79

  Fly    92 ESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVN 156
            |:::.:...||.||...|  |||||:::....|.||:.|.|.|.|:|...:|.|.||||..||.|
Frog    80 EAEKPEEDCRFTISAQSD--GRWALQSDPHKRFFGGSVDMLSCFAQTITETELWAVHLAIHPQAN 142

  Fly   157 LRSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVC 221
            |.|:.|:|:|||:..:||:..|:|||||.|:|.||.::.:   :|.|.||:|:||..:|||....
Frog   143 LLSVSRRRYAHLTPQEDEVSTDSNIPWGVDSLITLVYQDK---KYCLKTCDNRYLRNDGKLVKEP 204

  Fly   222 NEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKS-RSSSVTRDELFSLEDSLPQASFIAGLNL 285
            :|...::.|:..|.||.:|..|:||:|:|....||| |||...:||||.||:|.||..|:|. |.
Frog   205 DEGTGYTLEFKAGKLAFKDCSGKYLTPMGPTGTLKSGRSSKPGKDELFDLEESHPQVVFMAS-NR 268

  Fly   286 RYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADAL 350
            ||:|.:|||:|:|||||..:.||||::.:...::.:..|...:||.|.:.||||:|.....|:.:
Frog   269 RYISTRQGVNVSANQDEETDYETFQMQINKETNKCSFHTNAGKYWTLVSHGGIQSTATEIAANTM 333

  Fly   351 FELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRT 415
            |::.|.| ..::.:|:|||::.||::|.|.|..:::.|..:|...|||||||||:.:.|||.:..
Frog   334 FDIEWRG-RKVALKASNGKYICTKKNGQLAAVGDTVGEDEEFILKLINRPILVLRGDLGFVCHHK 397

  Fly   416 PGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGE-SISVDADAPSDGFFLELREPTRI 479
            ..|: |:.|:::|:...: ....|...:|...||:|.|... :|..|.|. |:.||.|.||..|:
Frog   398 TSNM-LDANRSSYDVFQI-IFNNGAYQIKGQGGKFWYISSNGTICSDGDM-SEEFFFEFREHNRV 459

  Fly   480 CIRSQQGKYLGATKNGAFKLLDDGTDSATQWEF 512
            .|:.:.|:||...:.|..|...:..:|||.||:
Frog   460 AIKGKNGRYLRGDQAGTLKADAESVNSATLWEY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sn	NP_001162697.1	Fascin	33..147	CDD:283843	53/114 (46%)
		Fascin	152..270	CDD:238160	53/118 (45%)
		Fascin	275..394	CDD:238160	45/118 (38%)
		Fascin	399..512	CDD:238160	39/113 (35%)
fscn2	NP_001093724.1	Fascin	21..133	CDD:368822	53/113 (47%)
		Fascin	138..254	CDD:238160	53/118 (45%)
		Fascin	267..376	CDD:368822	41/109 (38%)
		Fascin	381..492	CDD:238160	39/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6277
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22722
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1985
OMA	1	1.010	-	-		QHG52513
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002949
OrthoInspector	1	1.000	-	-		otm48225
Panther	1	1.100	-	-	O	PTHR10551
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4757
SonicParanoid	1	1.000	-	-		X1949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100