Protein Alignment sws and NTE1

DIOPT Version :10

• Sequence 1: NP_511075.3
• Gene: sws / 31716
• FlyBaseID: FBgn0003656
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: NP_013652.1
• Gene: NTE1 / 854943
• SGDID: S000004524
• Length: 1679
• Species: Saccharomyces cerevisiae
• Alignment Length: 1680
• Identity: 404/1680 - (24%)
• Similarity: 704/1680 - (41%)
• Gaps: 481/1680 - (28%)

  Fly     5 EMLRASASGSYNTIFSDAW-CQYVSKQITATVYMY-FALVMMSLLFIAWFLYFKRMARLRLRDEI 67
            :::..:.:.|.:::|:.:| ..|.....:..::.| :.|..:|||.|..:::||
Yeast    43 QIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFK----------- 96

  Fly    68 ARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQL 132
                         :..::|.....::.:...::         ::.:....|.|.:.::.|    |
Yeast    97 -------------LHHVQFTLSFWLILFALAVI---------VFVTYTIMKERILSQYKR----L 135

  Fly   133 RRDNMPLEMRTVEPPAEYLEETIEGSDRVPPD-----------------------------ALYM 168
            ..:.:|||.......:..:......|...||.                             :.|:
Yeast   136 TPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYL 200

  Fly   169 ---LQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYL-------FKIT------------------ 205
               |.:|:|||:.|||||..|.|:.:..::..|:.|       |.|.
Yeast   201 DQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDH 265

  Fly   206 ----------------------DPDDSV--YIVQSGMIN-----------VYISNADGSTLSLKT 235
                                  :.||.:  |..:|...|           :::.|..|:...|.|
Yeast   266 GDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNT 330

  Fly   236 VRKGESVTSLLSFIDVLS------GN--------------------------------------- 255
            |:.|..:|||:|.:::.:      ||
Yeast   331 VKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTN 395

  Fly   256 -----PSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLG 315
                 ||....:.|:|.....:..:|.|:|.::....|.....:||:::.:|..|.|....:|||
Yeast   396 SFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLG 460

  Fly   316 LNAELVQNHM--------------------RYKSVSTMSG-------PINSQTSQSSRQAPNGPP 353
            |..|::...:                    ::|:|...||       |.||..|...::.|...|
Yeast   461 LTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKP 525

  Fly   354 M--VISQMNLMQSAVSGTGSSGVSV--TVTRPPSSPSRH----SREE-------------HTLSD 397
            .  :|..:.: .:|.:.|.|:.:|:  ..|..||  |||    ||::             .|:..
Yeast   526 SDGIIQSLKI-ANANANTSSNSLSLKPEFTHHPS--SRHVVLGSRDQFNPGDLLSNVPLSRTMDI 587

  Fly   398 PNPNP-----------------------------DGSFHG-----------------------TT 410
            .:|||                             :.|.|.                       .|
Yeast   588 LSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNT 652

  Fly   411 NLFTEVHGD--------APNADLF-------HQQQQQHSV-----------------GNLSTRRS 443
            ::...:|..        :|..:|.       .|::.:.|.                 .|:|...|
Yeast   653 SVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSS 717

  Fly   444 SI----TLMAPD---------GSHSCLQTPGVTTSIDMRLVQSSA--------VDSLRKELGLS- 486
            ||    :|.:|.         .:.|.|.:|..|.| |:.:..|.|        :..|.||..:|
Yeast   718 SIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPS-DISVASSFASPQTQPTMLRILPKEYTISN 781

  Fly   487 -------EEDSHIIEPFVELRELEPNV---------------------TLITEGNADDVCVWFVM 523
                   .:|..  :|.....||.||:                     |.|.|.||....:::::
Yeast   782 KRHNKSKSQDKK--KPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYII 844

  Fly   524 TGTLAVYQSNQDATRAKQDKSDM-----------------LIHFVHPGEIVGGLAMLTGEASAYT 571
            :|.:.|..::..:..:...|.:.                 |::.|..|.|||.|:.|.|..|...
Yeast   845 SGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVN 909

  Fly   572 IRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQD 636
            |.::|...:.|:..|.:.::..:...|.|.:.:.:.:.||..:.:.|:||:|:.|.:...::.|.
Yeast   910 IVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQG 974

  Fly   637 ESSDSTYIVLSGRMRSV----ITHPGGKKE-------IVGEYGKGDLVGIVEMITETSRTTTVMA 690
            :|::..|:||:||:|.:    :::.....|       |:||..:|:..|.||::|..:|.:|::|
Yeast   975 DSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVA 1039

  Fly   691 VRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGA-----------PVE 744
            |||||||::|..||..:.|.:|.::.::...::.:.:|.....:.:|.|.:           |.:
Yeast  1040 VRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTK 1104

  Fly   745 A---NPVTHK----------YSTVALVPITDEVPMTPFTYELYHSLCAIG-PVLRLTSDVVRKQL 795
            |   :.::||          :.|:.::|||..:|:..|..:|..:...:| ..:.|........|
Yeast  1105 ASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHL 1169

  Fly   796 GSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSL-SAWTQRCMRQADVILIVGLGDR---SHLV 856
            |.:.|:..::.:.:.:.|:.|:.....:|..|:.: |.||:.|:.|.|.||:  |.|.   |..:
Yeast  1170 GRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILL--LADARSPSAEI 1232

  Fly   857 GKFEREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHV---------------- 905
            |::|:.:.......:.||:||:|| ...:|..|..||..||||..|||:
Yeast  1233 GEYEKLLLNSKTTARTELILLHPE-RYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMH 1296

  Fly   906 --------LCVKRI---FTRKSQYRINDLY------------SRVLLSEPNMH-------SDFSR 940
                    |..|.|   |:||:|..|:.|.            ||.:.|:...:       :||.|
Yeast  1297 VLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLR 1361

  Fly   941 LARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQ 1005
            |||.|:|.:||||||||||||.:|:|:::||:|.|||||::||.|||:.:|.|:..:.::..:..
Yeast  1362 LARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYG 1426

  Fly  1006 KAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHR 1070
            :.::::.:::..:..|.|||:|:||..:|.|||:.|..||||..|||.||.|:..:|:||.|...
Yeast  1427 RVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQE 1491

  Fly  1071 IHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDD 1135
            ||:.|..|||:|:||||:|.:|||  .::|.:|||||||:|||...|...|...|.|:||||.||
Yeast  1492 IHSFGYAWRYIRASMSLAGLLPPL--EENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADD 1554

  Fly  1136 TDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPID 1200
            .....|||.|:|:|:::.:||||:|...:|::.:||.||.||:.|..||:.||:....|:||||:
Yeast  1555 RTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIE 1619

  Fly  1201 KYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRL----GRFNQWFNKEPPKRVNH 1251
            :|.||.|..|:||..||..:|:.:.:.:....::    |......|.:.|:.:.|
Yeast  1620 EYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLH 1674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	CAP_ED	174..295	CDD:237999	39/230 (17%)
		Crp	484..>610	CDD:440428	31/171 (18%)
		CAP_ED	620..719	CDD:237999	36/109 (33%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	138/315 (44%)
NTE1	NP_013652.1	Crp	809..>944	CDD:440428	24/134 (18%)
		CAP_ED	957..1067	CDD:237999	36/109 (33%)
		Pat_Fungal_NTE1	1361..1629	CDD:132865	129/269 (48%)