DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and pnpla7a

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001074124.1	Gene:	pnpla7a / 791173	ZFINID:	ZDB-GENE-070112-1812	Length:	328	Species:	Danio rerio

Alignment Length:	285	Identity:	109/285 - (38%)
Similarity:	170/285 - (59%)	Gaps:	27/285 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QYVSKQITATV---YMYFALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRF 86
            |:|.:::..|:   .:..|.|.:.|:.|...|.::|.........:.|              .||
Zfish    24 QFVEERMQTTMLTGVLIGAAVAVCLIGITVLLLYRRYKHASQEAGVPR--------------YRF 74

  Fly    87 RKRDKMLFYGRRMLRKMKNVS----GQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPP 147
            |||||:|||||:::||::.:|    ..:.|..:..||..|:..|||||::|::  |..::..|||
Zfish    75 RKRDKVLFYGRKIMRKVQTLSSTPTSTLVSKQRSRKRPKVLSIARRILRIRKE--PPTLQPKEPP 137

  Fly   148 AEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPD 208
            ...||..:...|    .:|.:.||||:::|:.||||||:||.||:|...:||..|:.|||..|.|
Zfish   138 PSLLEADLTEFDVQNSNLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFVELQEGEGLFKPGDDD 202

  Fly   209 DSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVI 273
            ||:|:||.|.:.:.|...||:.|.:|.|..|:||.||||.:|:::|.|:.||||:|:|..:|.::
Zfish   203 DSIYVVQDGRLELCILEIDGTELVVKDVLPGDSVHSLLSILDIITGYPAPYKTVSARAAVRSTIL 267

  Fly   274 RLPMQAFEEVFQDNPDVMIRVIQVI 298
            |||..||:.||:..|:.::|||||:
Zfish   268 RLPASAFQSVFEKYPETLVRVIQVL 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	64/131 (49%)
		CAP_ED	174..295	CDD:237999	57/120 (48%)
		Crp	483..>611	CDD:223736
		CAP_ED	484..602	CDD:237999
		CAP_ED	620..719	CDD:237999
		Crp	624..>727	CDD:223736
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
pnpla7a	NP_001074124.1	Crp	162..>293	CDD:223736	64/131 (49%)
pnpla7a	NP_001074124.1	CAP_ED	168..289	CDD:237999	57/120 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594075
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R845
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960