DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and pnpla6

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	XP_005160109.1	Gene:	pnpla6 / 560986	ZFINID:	ZDB-GENE-050107-4	Length:	1343	Species:	Danio rerio

Alignment Length:	1400	Identity:	586/1400 - (41%)
Similarity:	813/1400 - (58%)	Gaps:	202/1400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQM 110
            ::.||..::|. :.|::||...|:.:..          .|||||||:|||||:::||:...:..:
Zfish    46 IVLIAVLIFFV-LRRMQLRKLEAQEVPK----------YRFRKRDKVLFYGRKIMRKVSQSTSSL 99

  Fly   111 YSSGKG-----YKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSD----RVPPDAL 166
            ..:...     .|::.::..|::||:.:::...|:|:  |||...||..:...|    .:|.:.|
Zfish   100 VGATSSTRPRLKKKQKMLNIAKKILRFKKEVPTLQMK--EPPPSVLEADLTEFDVANSHLPSEVL 162

  Fly   167 YMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTL 231
            |||:::|:.||||||:||.||||...|:...|:|:|:...||.|:|:||.|.:.:.::..||...
Zfish   163 YMLKNVRVLGHFEKPLFLELCKHMVFLQFQQGEYVFRPGQPDSSIYVVQDGKLELCLTGQDGKDG 227

  Fly   232 SLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQ 296
            .:|.|..|:||.||||.:||::|:...||||:|:|.|.|.|:|||:.||..:|:..|:.::||:|
Zfish   228 VVKEVYPGDSVHSLLSILDVITGHQRPYKTVSARAAEVSTVLRLPVDAFLSIFEKYPESLVRVVQ 292

  Fly   297 VIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNL 361
            :||:|||||...||.|||||..||..:.|:.:
Zfish   293 IIMVRLQRVTVLALHNYLGLTNELFSHEMQPR--------------------------------- 324

  Fly   362 MQSAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPN-------PNPDGSFHGTTNLFTEVHGD 419
                     ||.:|...||  |||.|||:...:|:.|:       .|..|..||...      |.
Zfish   325 ---------SSPLSPHPTR--SSPVRHSKRFGSLTVPDKHREAAVQNATGGDHGKEG------GT 372

  Fly   420 APN--------ADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAV 476
            .|.        .|:...|:...|..:::..|..|::.|.||      .|..|.....|.|   .|
Zfish   373 IPTLSRTISMPVDIAGMQKSLRSDFDMAYERGRISVSAEDG------VPAFTKEQRERKV---TV 428

  Fly   477 DSLRKELGLSEEDSHIIEPFVELRELEPNVTLITEGNAD-------------------------- 515
            |.:...:.|..|:...::.|...:. .||.|:..|...:
Zfish   429 DEVPSGVYLYPEEESGMDIFSSFQG-RPNATVFEEAQKEILRLMKIEDPSLLNGRVTFHHAKAGS 492

  Fly   516 --------DVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFV-HPGEIVGGLAMLTGEASAYT 571
                    ||.:.||::|.|.|||.       ..||.:.:..|| .|||:||.||:||||...:|
Zfish   493 VLARQGDQDVSLHFVLSGCLHVYQK-------MIDKQEAVCLFVTQPGEMVGQLAVLTGEPLIFT 550

  Fly   572 IRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQD 636
            |::........|.::..|:|||::|.:||...:.|..|:|..|||.|:|:||:.:|:|||:||||
Zfish   551 IKAERDCTFLKISKSEFYEIMREQPSVVLSAAHTVAIRMSAFVRQMDFAIDWMAVEAGRALYRQD 615

  Fly   637 ESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPE 701
            :.||.|||||:||:||||....||||:|||||:|||:|:||.:|...|.|||.||||:||.||||
Zfish   616 DQSDCTYIVLNGRLRSVIRKANGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELVKLPE 680

  Fly   702 GLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSG---SGAPGAPVEA------NPVTHKYSTVAL 757
            |..|.||.|||.|||:||..|..:.||::|...|   |.|.|.|..|      ||.:: .||||:
Zfish   681 GTLNNIKRRYPQVVTRLIHLLGQKILGNLQQPRGPFSSSALGLPSMASSPDVTNPASN-LSTVAV 744

  Fly   758 VPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTSWLAQQEDRNIIT 822
            :|:.||||:..|..||.|:|.||||.|.||||::|::||::..::.:||||:.|||||||.|.|.
Zfish   745 LPVCDEVPINAFNLELSHALSAIGPTLLLTSDIIRERLGASALDSIHEYRLSGWLAQQEDINRIV 809

  Fly   823 LYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEASNAKPA 887
            |||.||.::.|||||:||||.||||||||:...:|:.|:.::..|:|..|:|:||:.| ....|:
Zfish   810 LYQTDSGMTPWTQRCIRQADCILIVGLGDQEPALGELEQMLENTAVRALKQLILLHRE-DGPGPS 873

  Fly   888 NTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGL 952
            .|:.|||.|.|.:.|.|:.|.:|:|:|:|..::.::|.:|.....:.|||||||||.||||||.|
Zfish   874 RTVEWLNMRSWCSGHLHLKCPRRVFSRRSPTKLREVYEKVFEKTADRHSDFSRLARVLTGNSIAL 938

  Fly   953 VLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKW 1017
            |||||||||.:|:|::||:::.|||:|:|||.|||:.:|||:..||:...|.|:||||||.|...
Zfish   939 VLGGGGARGCSHVGVIKAMEDTGIPIDIVGGTSIGSFIGALYAEERSAVRVKQRAREWSKAMNSV 1003

  Fly  1018 FLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVR 1082
            |..:|||||||||||||..||.:|...|.|..|||||:|||.:|||||||..|:|.:||||||||
Zfish  1004 FKTVLDLTYPITSMFSGSAFNTSISKVFEDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVR 1068

  Fly  1083 SSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSG 1147
            :||:||||:|||||||||:||:||||:||||||:...||...:|||||||||:|||.||||.|||
Zfish  1069 ASMTLSGYLPPLCDPKDGNLLMDGGYINNLPADIARTLGTKTVIAIDVGSQDETDLCNYGDCLSG 1133

  Fly  1148 WWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDE 1212
            ||||:|:.||:...|||||:.:|||||||||||||||.||.|.||||||||||::||:.||.|||
Zfish  1134 WWLLWKRINPWAEKVKVPDMAEIQSRLAYVSCVRQLELVKKSAYCEYIRPPIDRFKTMDFGKFDE 1198

  Fly  1213 IRDVGYVFGKNYF---------ESMAKAGRLGRFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCR 1268
            |.||||..||..|         ::|.|..|...:|.      .|:.:........|.|||:||.|
Zfish  1199 IYDVGYQHGKLVFTEWARGDIIDNMLKDHRSADYND------SKKTDSCPCPSADFTDLAEIVSR 1257

  Fly  1269 LPETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDS--DVELDLKLE 1331
            :....:...|:  :|:.|   |.:|                     :.|..||:  :.|.:.:.|
Zfish  1258 IEPVQSYVGAD--AEESD---YATE---------------------YEEDGMDTVREEEGEEEEE 1296

  Fly  1332 RKTDKSTQSS---------PPSNSRSDMRGKEEAR 1357
            ...|...||.         ||...::..:.|..:|
Zfish  1297 EGEDPEDQSPGEWGPNGVFPPDEDKTVRQRKNVSR 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	66/141 (47%)
		CAP_ED	174..295	CDD:237999	54/120 (45%)
		Crp	483..>611	CDD:223736	43/162 (27%)
		CAP_ED	484..602	CDD:237999	41/152 (27%)
		CAP_ED	620..719	CDD:237999	64/98 (65%)
		Crp	624..>727	CDD:223736	64/102 (63%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	204/313 (65%)
		RssA	940..1222	CDD:224666	192/281 (68%)
pnpla6	XP_005160109.1	TM_EGFR-like	31..64	CDD:213052	5/18 (28%)
		Crp	164..>302	CDD:223736	65/137 (47%)
		CAP_ED	170..291	CDD:237999	54/120 (45%)
		Crp	466..>596	CDD:223736	39/136 (29%)
		CAP_ED	467..577	CDD:237999	32/116 (28%)
		CAP_ED	590..698	CDD:237999	69/107 (64%)
		Crp	605..>706	CDD:223736	64/100 (64%)
		Pat_PNPLA6_PNPLA7	921..1226	CDD:132864	201/304 (66%)
		RssA	926..1216	CDD:224666	195/289 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594077
Domainoid	1	1.000	248	1.000	Domainoid score	I2103
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1035	1.000	Inparanoid score	I267
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm26121
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	O	PTHR14226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770