DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and PRKG2

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	XP_016863902.1	Gene:	PRKG2 / 5593	HGNCID:	9416	Length:	774	Species:	Homo sapiens

Alignment Length:	392	Identity:	75/392 - (19%)
Similarity:	137/392 - (34%)	Gaps:	112/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 QMNLMQSAVSGTGSSGVSVTVTRPPSSPSR--------HSR---------EEHTLS-DPNPNPDG 404
            |:|.:|..|...|.|.:..:..:.|....|        |||         |..|.: |.|..|:.
Human    78 QLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEF 142

  Fly   405 SFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMR 469
            ||                        ::..|...|:.:..||
Human   143 SF------------------------EKARVRKDSSEKKLIT----------------------- 160

  Fly   470 LVQSSAVDSLRKELGLSEEDSHIIEPFVEL---RELEPNVTLITEGNADDVCVWFVMTGTLAVYQ 531
                   |:|.|...|...|...|:..||.   |..:....:|.:|...: .::.:..|.|.|:|
Human   161 -------DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGN-HIFVLAEGRLEVFQ 217

  Fly   532 SNQDATRAKQDKSDMLIHFVHPGEIVGGLAML-----TGEASAYT-IRSRSITRIAF---IRRAA 587
                        .:.|:..:......|.||:|     |....|.| :::.::.|..|   :||.|
Human   218 ------------GEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTA 270

  Fly   588 IYQIMRQRP--RIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRM 650
            ..:..:.|.  |.|..|.|....:|:.:: .|   |:..:.:.|..:.|:.|...:.:|:..|::
Human   271 QARDEQYRNFLRSVSLLKNLPEDKLTKII-DC---LEVEYYDKGDYIIREGEEGSTFFILAKGKV 331

  Fly   651 RSVITHPG-GKKEIVGEYGKGDLVGIVEMITETSRTTTVMA--------VRDSELAKLPEGLFNA 706
            :...:..| .:.:::....||:..|...:|::..|:..::|        |.|.|......|.|..
Human   332 KVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEE 396

  Fly   707 IK 708
            ::
Human   397 LQ 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	30/141 (21%)
		CAP_ED	484..602	CDD:237999	28/131 (21%)
		CAP_ED	620..719	CDD:237999	18/98 (18%)
		Crp	624..>727	CDD:223736	17/94 (18%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
PRKG2	XP_016863902.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900