DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sws and PRKAR2B

DIOPT Version :9

Sequence 1:NP_511075.3 Gene:sws / 31716 FlyBaseID:FBgn0003656 Length:1425 Species:Drosophila melanogaster
Sequence 2:NP_002727.2 Gene:PRKAR2B / 5577 HGNCID:9392 Length:418 Species:Homo sapiens


Alignment Length:364 Identity:78/364 - (21%)
Similarity:136/364 - (37%) Gaps:87/364 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 NLMQSAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNAD 424
            :|..:|..||.|.||:. ...|..|.|....||    :..|...|:|            :||   
Human    60 DLGAAAGGGTPSKGVNF-AEEPMQSDSEDGEEE----EAAPADAGAF------------NAP--- 104

  Fly   425 LFHQQQQQHSVGNLSTRRSSITLMA--PDGSHSCLQTPGVTTSID---MRLVQSSAVDSLRKELG 484
                      |.|..|||:|:...|  ||......::..:....|   .||.::.....|.|.|.
Human   105 ----------VINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLD 159

  Fly   485 LSEEDSHIIEPFVELRELEPNVTLITEG-----NADDVCVWFVM-TGTLAVYQSNQDATRAKQDK 543
             .|:.|.:::...|        .|:.:|     ..||...::|: .||..:|.......|.    
Human   160 -PEQMSQVLDAMFE--------KLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC---- 211

  Fly   544 SDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRS------ITRIAFIRRAAIYQIMRQRPRIVLDL 602
               :.::.:.|.. |.||::.....|.||.:.|      :.|:.| ||..:....::|     .:
Human   212 ---VGNYDNRGSF-GELALMYNTPRAATITATSPGALWGLDRVTF-RRIIVKNNAKKR-----KM 266

  Fly   603 GNGVVRRLSPLVRQCDYA-----LDWI---FLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGG 659
            ....:..| |.::..:::     :|.|   ....|..:..|.:|:||.:||.||.::..:... |
Human   267 YESFIESL-PFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRK-G 329

  Fly   660 KKEI-------VGEYGKGDLVGIVEMITETSRTTTVMAV 691
            |.|:       :....:|...|.:.::|...|..:..|:
Human   330 KSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAI 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swsNP_511075.3 Crp 168..>310 CDD:223736
CAP_ED 174..295 CDD:237999
Crp 483..>611 CDD:223736 26/139 (19%)
CAP_ED 484..602 CDD:237999 25/129 (19%)
CAP_ED 620..719 CDD:237999 19/87 (22%)
Crp 624..>727 CDD:223736 18/78 (23%)
Pat_PNPLA6_PNPLA7 935..1240 CDD:132864
RssA 940..1222 CDD:224666
PRKAR2BNP_002727.2 Dimerization and phosphorylation 2..153 29/122 (24%)
DD_RIIbeta_PKA 3..43 CDD:213051
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 48..96 12/40 (30%)
Crp 150..>259 CDD:223736 27/126 (21%)
CAP_ED 154..267 CDD:237999 28/135 (21%)
Crp 270..>385 CDD:223736 21/101 (21%)
CAP_ED 276..396 CDD:237999 19/94 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0664
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.