DRSC/TRiP Functional Genomics Resources

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Protein Alignment sws and PRKAR2A

DIOPT Version :9

Sequence 1:NP_511075.3 Gene:sws / 31716 FlyBaseID:FBgn0003656 Length:1425 Species:Drosophila melanogaster
Sequence 2:NP_001308911.1 Gene:PRKAR2A / 5576 HGNCID:9391 Length:404 Species:Homo sapiens


Alignment Length:356 Identity:76/356 - (21%)
Similarity:134/356 - (37%) Gaps:85/356 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   380 RPPSS--PSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRR 442
            |.|:|  |:...|:......|.|.||        ...:..||:.:.:   .:..:..|.:...||
Human    44 RAPASVLPAATPRQSLGHPPPEPGPD--------RVADAKGDSESEE---DEDLEVPVPSRFNRR 97

  Fly   443 SSITLMAPDGSHSCLQT-----------PGV----TTSIDMRLVQSSAVDSLRKELGLSEEDSHI 492
            .|:          |.:|           |.|    |.....||.::.....|.|.|. .|:.|.:
Human    98 VSV----------CAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLD-QEQLSQV 151

  Fly   493 IEPFVELRELEPNVTLITEGNADDVCVWFVM---TGTLAVYQSNQDATRAKQDKSDMLIHFVHPG 554
            ::...| |.::.:..:|.:|  ||...::|:   |..:.|.:.||..:..:.|.....       
Human   152 LDAMFE-RIVKADEHVIDQG--DDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSF------- 206

  Fly   555 EIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRL-------SP 612
               |.||::.....|.||.:.|        ..:::.:.|...|.::...|...|::       .|
Human   207 ---GELALMYNTPRAATIVATS--------EGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVP 260

  Fly   613 LVRQCDYA-----LDWI---FLESGRAVYRQDESSDSTYIVLSG------RMRSVITHPGGKKEI 663
            |::..:.:     :|.|   ..:.|..:..|.|.:||.||:.||      |.|:.....||.:|:
Human   261 LLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEV 325

  Fly   664 -VGEYGKGDLVGIVEMITETSRTTTVMAVRD 693
             :....||...|.:.::|...|..:..||.|
Human   326 EIARCHKGQYFGELALVTNKPRAASAYAVGD 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swsNP_511075.3 Crp 168..>310 CDD:223736
CAP_ED 174..295 CDD:237999
Crp 483..>611 CDD:223736 26/137 (19%)
CAP_ED 484..602 CDD:237999 23/120 (19%)
CAP_ED 620..719 CDD:237999 24/89 (27%)
Crp 624..>727 CDD:223736 23/80 (29%)
Pat_PNPLA6_PNPLA7 935..1240 CDD:132864
RssA 940..1222 CDD:224666
PRKAR2ANP_001308911.1 Dimerization and phosphorylation 2..138 22/114 (19%)
DD_RIIalpha_PKA 4..44 CDD:213050 76/356 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..90 9/53 (17%)
Crp 135..>244 CDD:223736 26/130 (20%)
CAP_ED 139..251 CDD:237999 28/133 (21%)
Crp 255..>371 CDD:223736 26/102 (25%)
CAP_ED 261..382 CDD:237999 25/96 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0664
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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