DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and PRKAR1B

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001158230.1	Gene:	PRKAR1B / 5575	HGNCID:	9390	Length:	381	Species:	Homo sapiens

Alignment Length:	399	Identity:	82/399 - (20%)
Similarity:	141/399 - (35%)	Gaps:	116/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 PPSSPSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHG-----------------DAPNADL--- 425
            ||:.||    ||          |.|..| ..|:.::||                 :.|...|
Human     4 PPACPS----EE----------DESLKG-CELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREH 53

  Fly   426 FHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTP--------------GVTTSIDMRLVQSSAV 476
            |.:.:::.:...|:.::|:    :...||....:|              ||:..:   ..:..||
Human    54 FEKLEKEENRQILARQKSN----SQSDSHDEEVSPTPPNPVVKARRRRGGVSAEV---YTEEDAV 111

  Fly   477 DSLRKEL------------GLSE----------EDSHIIEPFVELRELEPNVTLITEGNADDVCV 519
            ..:||.:            .:|:          |.|.|.:....:..: ...|:|.:||..| ..
Human   112 SYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGD-NF 174

  Fly   520 WFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSR--------- 575
            :.|..|.:.||.:.:..|.            :..|...|.||::.|...|.|::::
Human   175 YVVDQGEVDVYVNGEWVTN------------ISEGGSFGELALIYGTPRAATVKAKTDLKLWGID 227

  Fly   576 --SITRI---AFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQ 635
              |..||   :.:|:..:|:....:..|:..|...  .||:    ..| ||:.:..|.|..:..|
Human   228 RDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKW--ERLT----VAD-ALEPVQFEDGEKIVVQ 285

  Fly   636 DESSDSTYIVLSGRMRSVITHPGGKKEI--VGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAK 698
            .|..|..||:..| ..||:......:|.  ||..|..|..|.:.::....|..||:|....:..|
Human   286 GEPGDDFYIITEG-TASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVK 349

  Fly   699 LPEGLFNAI 707
            |....|..:
Human   350 LDRPRFERV 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	29/163 (18%)
		CAP_ED	484..602	CDD:237999	27/141 (19%)
		CAP_ED	620..719	CDD:237999	25/90 (28%)
		Crp	624..>727	CDD:223736	23/86 (27%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
PRKAR1B	NP_001158230.1	Dimerization and phosphorylation	2..136		27/153 (18%)
		DD_RIbeta_PKA	11..64	CDD:213049	10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..98		4/34 (12%)
		Pseudophosphorylation motif	96..100		0/3 (0%)
		CAP_ED	137..246	CDD:237999	24/122 (20%)
		CAP_ED	255..370	CDD:237999	30/112 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900