DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and Pnpla6

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001346052.1	Gene:	Pnpla6 / 50767	MGIID:	1354723	Length:	1359	Species:	Mus musculus

Alignment Length:	1321	Identity:	572/1321 - (43%)
Similarity:	796/1321 - (60%)	Gaps:	107/1321 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RFRKRDKMLFYGRRMLRKMKNVSGQMY-------SSGKGYKRRAVMRFARRILQLRRDNMPLEMR 142
            |||||||:|||||:::||:...:..:.       |..:..|:..::..|::||:::::...|:.:
Mouse    81 RFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRK 145

  Fly   143 TVEPPAEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFK 203
              |||...||..:...|    .:|.:.||||:::|:.||||||:||.||:|.....|..|||:|:
Mouse   146 --EPPPSVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFR 208

  Fly   204 ITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIE 268
            ...||.|:|:||.|::.:.:...||....:|.|..|:||.||||.:||::|:....:||:|:|..
Mouse   209 PGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAAR 273

  Fly   269 KSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMR------Y 327
            .|.|:|||::||..||...|:.::||:|:||:|||||.|.||.|||||..||..:.::      .
Mouse   274 DSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPS 338

  Fly   328 KSVSTMSGPI--------NSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSS 384
            ..:.|.:.|:        .|.|..:|::....|      ::.:.:.:.|.....|..|....|.:
Mouse   339 PGLPTRTSPVRGSKRVVSTSGTEDTSKETSGRP------LDSIGAPLPGPAGDPVKPTSLEAPPA 397

  Fly   385 P--SRHSREEHTLSDPNPNPDGSF-----HG--TTNLFTEVHGD-------APNADLFHQQQQQH 433
            |  ||.......:|.....|...|     .|  :.:|..|..|.       .|..:|  ::|...
Mouse   398 PLLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRTPTQEL--REQPAG 460

  Fly   434 SVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELG--LSEEDSHIIEPF 496
            :.........|.|...|.|.:...||             ||..::.::||.  :..||..::...
Mouse   461 ACEYSYCEDESATGGCPFGPYQGRQT-------------SSIFEAAKRELAKLMRIEDPSLLNSR 512

  Fly   497 VELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFV-HPGEIVGGL 560
            |.|...:....:..:|: .||.:.||:.|.|.|||       ...||::.:..|| .|||:||.|
Mouse   513 VLLHHAKAGTIIARQGD-QDVSLHFVLWGCLHVYQ-------RMIDKAEEVCLFVAQPGELVGQL 569

  Fly   561 AMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIF 625
            |:||||...:|:|::.......|.::..|:|||.:|.:||...:.|..|:||.|||.|:|:||..
Mouse   570 AVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTA 634

  Fly   626 LESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMA 690
            :|:|||:|||.:.||.|||||:||:||||....||||:|||||:|||:|:||.:|...|.|||.|
Mouse   635 VEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHA 699

  Fly   691 VRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVE-------ANPV 748
            |||:||||||||....||.|||.|||:||..||.:.||::|...|. .||:.:.       .||.
Mouse   700 VRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGP-FPGSGLSVPQHSELTNPA 763

  Fly   749 THKYSTVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTSWLA 813
            :: .||||::|:..||||..||.||.|:|.||||.|.|.|||:|..||::..::..|:||:.|||
Mouse   764 SN-LSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGASALDSIQEFRLSGWLA 827

  Fly   814 QQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLY 878
            ||||.:.|.|||.|:||:.||.||:||||.||||||||:...||:.|:.::..|:|..|:||||:
Mouse   828 QQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTVGQLEQMLENTAVRALKQLVLLH 892

  Fly   879 PEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLAR 943
            .| ....|..|:.|||.|.|.:.|.|:.|.:|:|:|:|..::::||.:|.....:.|||||||||
Mouse   893 RE-EGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLAR 956

  Fly   944 WLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAR 1008
            .||||:|.||||||||||.:|||:|||::|||:|||:|||.|||:.:|||:..||:.:...|:||
Mouse   957 VLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAR 1021

  Fly  1009 EWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHT 1073
            ||:|.||.....:||||||:||||:|..||::||..|.|..|||||:|||.:|||||||..|:|.
Mouse  1022 EWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHK 1086

  Fly  1074 NGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDL 1138
            :||||||||:||:||||:||||||||||||:||||:||||||:..::||..:|||||||||:|||
Mouse  1087 DGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDL 1151

  Fly  1139 TNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYK 1203
            :.|||.|||||||:|:.||:...|||||:.:|||||||||||||||.||:|.||||:||.||.:|
Mouse  1152 STYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFK 1216

  Fly  1204 TLAFGSFDEIRDVGYVFGKNYF---------ESMAKAGRLGRFNQWFNKEPPKRVNHASLNEYTF 1259
            |:.||.||:|.||||.:||..|         |.|....|....|:      .:|.:..:.....|
Mouse  1217 TMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNE------SRRADILAFPSSGF 1275

  Fly  1260 IDLAQIVCRL-PETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDSD 1323
            .|||:||.|: |.|..|:......|:.||.....|....:..|..      |.|...:.....|:
Mouse  1276 TDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDE------GGSPEGASPSTASE 1334

  Fly  1324 VELDLKLERKTDKSTQSSPPS 1344
            ||.:....|:.....|.:|.|
Mouse  1335 VEEEKSTLRQRRFLPQETPSS 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	65/141 (46%)
		CAP_ED	174..295	CDD:237999	52/120 (43%)
		Crp	483..>611	CDD:223736	42/130 (32%)
		CAP_ED	484..602	CDD:237999	39/120 (33%)
		CAP_ED	620..719	CDD:237999	63/98 (64%)
		Crp	624..>727	CDD:223736	64/102 (63%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	201/313 (64%)
		RssA	940..1222	CDD:224666	189/281 (67%)
Pnpla6	NP_001346052.1	CAP_ED	179..300	CDD:237999	52/120 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..395		9/62 (15%)
		CAP_ED	497..607	CDD:237999	38/117 (32%)
		CAP_ED	620..728	CDD:237999	69/107 (64%)
		Pat_PNPLA6_PNPLA7	948..1253	CDD:132864	199/304 (65%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	969..974		4/4 (100%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	996..1000		2/3 (67%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1118..1120		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1290..1359		15/72 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848579
Domainoid	1	1.000	250	1.000	Domainoid score	I2102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1028	1.000	Inparanoid score	I275
Isobase	1	0.950	-	0	Normalized mean entropy	S2337
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm43019
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	O	PTHR14226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.820