DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and prkar2ab

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_998123.1	Gene:	prkar2ab / 405894	ZFINID:	ZDB-GENE-040426-2427	Length:	422	Species:	Danio rerio

Alignment Length:	343	Identity:	71/343 - (20%)
Similarity:	129/343 - (37%)	Gaps:	92/343 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 TVTRPPSSPSRHSREEHTLSDP-NPNPDGSFHGTTNLFTEVHGD-APNADLFHQQQQQHSVGNLS 439
            |...||  ||:.:|.....::| ||:.|           :..|| .....:.||:..:..
Zfish   103 TFKAPP--PSKCNRRVSVCAEPYNPDED-----------DDDGDEGSQLTVLHQKTDEQR----- 149

  Fly   440 TRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELGLSEED--SHIIEPFVELREL 502
                                        .||..:.....|.|.|   |||  :.:::...|:. :
Zfish   150 ----------------------------QRLQDACKHILLFKTL---EEDQLAEVLDSMFEVL-V 182

  Fly   503 EPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEA 567
            :|...:|.:|  ||...::|:...:......||..:....:.|      |.|.. |.||::....
Zfish   183 KPGECIINQG--DDGDNFYVIERGVYEIVIQQDGLQHSVGRYD------HKGSF-GELALMYNTP 238

  Fly   568 SAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRL-------SPLVRQCDYA----- 620
            .|.|||:        ::..|::.:.|.....::...|...||:       .||::....:
Zfish   239 RAATIRA--------LQEGALWALDRATFHRLIVKNNAKKRRMYESFIECVPLLKSLQLSERMKI 295

  Fly   621 LDWIFLES---GRAVYRQDESSDSTYIVLSGRMRSVITHPGG-----KKEI-VGEYGKGDLVGIV 676
            :|.:.:.|   |..:.:|.:|:|..|||.||.:|.:|.....     ::|: |....:|...|.:
Zfish   296 VDVLGMRSFSDGERIIQQGDSADCFYIVESGEVRIMIRSKTRACQLLQEEVEVARCSRGQYFGEL 360

  Fly   677 EMITETSRTTTVMAVRDS 694
            .::|:..|..:|.||.|:
Zfish   361 ALVTKRPRAASVYAVGDT 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	28/136 (21%)
		CAP_ED	484..602	CDD:237999	24/119 (20%)
		CAP_ED	620..719	CDD:237999	23/89 (26%)
		Crp	624..>727	CDD:223736	22/80 (28%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
prkar2ab	NP_998123.1	DD_RII_PKA	5..41	CDD:213046
		Crp	157..>266	CDD:223736	27/129 (21%)
		CAP_ED	161..274	CDD:237999	30/133 (23%)
		Crp	281..>392	CDD:223736	25/98 (26%)
		CAP_ED	283..403	CDD:237999	24/96 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900