DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and Prkar1b

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	XP_038945042.1	Gene:	Prkar1b / 25521	RGDID:	3392	Length:	381	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	80/391 - (20%)
Similarity:	141/391 - (36%)	Gaps:	100/391 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 SSPS-RHSREEHTLSDPNPNPDGSFHGTTNLFTEVHG-----------------DAPNADL---F 426
            :||| .||.:|.:|..            ..::.:.||                 |.|...|   |
  Rat     2 ASPSCFHSEDEDSLKG------------CEMYVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHF 54

  Fly   427 HQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTP------------GVTTSIDMRLVQSSAVDSL 479
            .:.:::.:...|:.::|:....:.|...|  .||            ||:..:   ..:..||..:
  Rat    55 EKLEKEENRQILARQKSNSQCDSHDEEIS--PTPPNPVVKARRRRGGVSAEV---YTEEDAVSYV 114

  Fly   480 RKEL------------GLSE----------EDSHIIEPFVELRELEPNVTLITEGNADDVCVWFV 522
            ||.:            .:|:          |.|.|.:....:..:: ..|:|.:||..| ..:.:
  Rat   115 RKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHID-GETVIQQGNEGD-NFYVI 177

  Fly   523 MTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRS------ITRIA 581
            ..|.:.||.:.:..|.            :..|...|.||::.|...|.|:::::      |.|.:
  Rat   178 DQGEVDVYVNGEWVTN------------ISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDS 230

  Fly   582 FIRRAAIYQIMRQRPRIVLDLGN-GVVRRLSPLVR--QCDYALDWIFLESGRAVYRQDESSDSTY 643
            : ||..:...:|:|......|.. .::..|....|  ..| ||:.:..|.|..:..|.|..|..|
  Rat   231 Y-RRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVAD-ALEPVQFEDGEKIVVQGEPGDDFY 293

  Fly   644 IVLSGRMRSVITHPGGKKEI--VGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNA 706
            |:..| ..||:......:|.  ||..|..|..|.:.::....|..||:|....:..||....|..
  Rat   294 IITEG-TASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFER 357

  Fly   707 I 707
            :
  Rat   358 V 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	27/156 (17%)
		CAP_ED	484..602	CDD:237999	26/133 (20%)
		CAP_ED	620..719	CDD:237999	25/90 (28%)
		Crp	624..>727	CDD:223736	23/86 (27%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
Prkar1b	XP_038945042.1	DD_RIbeta_PKA	11..64	CDD:213049	8/64 (13%)
		CAP_ED	137..246	CDD:237999	25/123 (20%)
		CAP_ED	255..370	CDD:237999	28/106 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900