DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and Pnpla7

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_653339.2	Gene:	Pnpla7 / 246246	RGDID:	708466	Length:	1349	Species:	Rattus norvegicus

Alignment Length:	1402	Identity:	599/1402 - (42%)
Similarity:	850/1402 - (60%)	Gaps:	142/1402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TIFSDAWCQYVSKQITATVYMYFAL-VMMSLLFI--AWFLYFKRMARLRLRDEIARSISTVTNSS 78
            |..|.....::.:...:|:.|...: |:::|.|:  |.|..:::::|.|..:...:
  Rat    17 TALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPTPQ--------- 72

  Fly    79 GDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSS-----GKGYKRRAVMRFARRILQLRRDNMP 138
                 .|||||||::||||:::||:..:...:..:     .:..||..|:..|:|||:.:::...
  Rat    73 -----YRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPT 132

  Fly   139 LEMRTVEPPAEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGD 199
            |:.:  |||...||..:...|    .:|.:.||||:::|:.||||||:||.||||...::|..|:
  Rat   133 LQPK--EPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGE 195

  Fly   200 YLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTA 264
            ::|:..:||.|:|:||.|.:.|.|.:|||:.:.:|.|..|:||.||||.:||::|:.:.||||:|
  Rat   196 HVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSA 260

  Fly   265 KAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMR--- 326
            :|...|.|:.||..||:.||:..|:.::||:|:||:|||||.|.||.|||||..||.....:
  Rat   261 RAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIP 325

  Fly   327 YKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSSPSRHSRE 391
            ..||::::|....|.|....:.....|. :|:.|         .|...||.|:.|        ..
  Rat   326 LLSVASVAGRAKRQMSYGPEEQLERSPR-LSEFN---------SSDQRSVAVSGP--------LL 372

  Fly   392 EHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSC 456
            :.:.|.|.|    ..||..:...:..|...|...| |:.|:.:..:|....:...::    .||.
  Rat   373 KRSCSVPLP----PIHGEIDELRQAQGSGSNTSAF-QESQEGATSDLGMAYNRARIL----PHSE 428

  Fly   457 LQTPGVTTSIDMRLV--QSSAV----DSLRKELGLSEEDSHII----EPFVELRELE-------- 503
            .|......|...:.|  ::|||    :..|.|.|.|.....|.    :..:.|.:|:
  Rat   429 EQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGR 493

  Fly   504 ------PNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAM 562
                  |..|::::....||.:.||::|.|.|||...|:.      .|..:...||||:||.||:
  Rat   494 VAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSL------EDTCLFLTHPGEMVGQLAV 552

  Fly   563 LTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLE 627
            ||||...:|||:........|.:|..|:|||:||.:||.:.:.||||:|..|||.|:||||:.:|
  Rat   553 LTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVE 617

  Fly   628 SGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVR 692
            :|||:|||.:.||.||||||||:||||....|||.:.||||:|||||:|||:|..:|.|||.|||
  Rat   618 AGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVR 682

  Fly   693 DSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEANPVTHKY----- 752
            ||||||||.|...:||.|||.|||:||..|..:.|||:|..||:   |..:..|..:.|:
  Rat   683 DSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGT---GHQLGFNTASSKWDLGNP 744

  Fly   753 ----STVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTSWLA 813
                ||||.:|::::||:|.|..||.|:|.||||||.||||.::::|||...::.:||||:|||.
  Rat   745 PGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLG 809

  Fly   814 QQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLY 878
            ||||.:.|.|||.||:|:.|||||:||||.||||||||:...:|:.|:.::..|:|.||:|:||:
  Rat   810 QQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLH 874

  Fly   879 PEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLAR 943
            .|...| |:.|:.|||.|.|.:.|.|:.|.:|:|:::|..::.::|:|:....|:.|||||||||
  Rat   875 KEEGPA-PSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLAR 938

  Fly   944 WLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAR 1008
            .||||:|.||||||||||.|.:|:|:|:.|.|||||::||.||||.||||:..||:.:.:..:|:
  Rat   939 ILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAK 1003

  Fly  1009 EWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHT 1073
            :|::.||.....:|||||||||||||..||.:|.:.|.|..|||||:|||.:|||||||..|:||
  Rat  1004 QWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHT 1068

  Fly  1074 NGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDL 1138
            :||||||||:||||||||||||||||||||:||||:|||||||..::||..:|||||||:|:|||
  Rat  1069 DGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDL 1133

  Fly  1139 TNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYK 1203
            |||||.|||||||:|:|||..:.|||.::.:||:|||||.||||||.|||||||||:|||||.|:
  Rat  1134 TNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYR 1198

  Fly  1204 TLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRF---NQWFNKEPPKRVNHASLNEYTFIDLAQI 1265
            ||.||.||||.:|||..|:..|:...::|.|.:.   .|..:|.  |.....:....:|.|||:|
  Rat  1199 TLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKR--KDCGVFTCPNSSFTDLAEI 1261

  Fly  1266 VCRLPETYAVNTAELFSEDEDCDGYISE--------PTTLNTDRRRIQVSRAGNSLSFSET--EM 1320
            |.|      :..|::.:.|::.| |.:|        |.....|              |..|  |:
  Rat  1262 VSR------IEPAKVAAVDDESD-YQTEYEEELPAIPKETYAD--------------FQSTGIEL 1305

  Fly  1321 DSDVELDLKLER-----KTDKSTQSSPPSNSRSDMRG 1352
            |||.|.:..:.:     .:.|.:|.|.|.....|.:|
  Rat  1306 DSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQG 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	68/141 (48%)
		CAP_ED	174..295	CDD:237999	55/120 (46%)
		Crp	483..>611	CDD:223736	47/145 (32%)
		CAP_ED	484..602	CDD:237999	43/135 (32%)
		CAP_ED	620..719	CDD:237999	65/98 (66%)
		Crp	624..>727	CDD:223736	64/102 (63%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	200/307 (65%)
		RssA	940..1222	CDD:224666	191/281 (68%)
Pnpla7	NP_653339.2	Crp	164..>306	CDD:223736	68/141 (48%)
		CAP_ED	170..291	CDD:237999	55/120 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		4/30 (13%)
		Crp	478..>607	CDD:223736	47/134 (35%)
		CAP_ED	478..588	CDD:237999	38/115 (33%)
		Crp	600..>729	CDD:223736	80/131 (61%)
		CAP_ED	601..709	CDD:237999	70/107 (65%)
		Involved in the binding to lipid droplets. /evidence=ECO:0000250\|UniProtKB:A2AJ88	678..964		147/289 (51%)
		Pat_PNPLA6_PNPLA7	930..1235	CDD:132864	200/304 (66%)
		RssA	935..1221	CDD:224666	192/285 (67%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	951..956		4/4 (100%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	978..982		2/3 (67%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1100..1102		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1349		14/60 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352176
Domainoid	1	1.000	250	1.000	Domainoid score	I2042
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62431
Inparanoid	1	1.050	1028	1.000	Inparanoid score	I259
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm45082
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810