Protein Alignment sws and Pnpla7

DIOPT Version :10

• Sequence 1: NP_511075.3
• Gene: sws / 31716
• FlyBaseID: FBgn0003656
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: NP_653339.2
• Gene: Pnpla7 / 246246
• RGDID: 708466
• Length: 1349
• Species: Rattus norvegicus
• Alignment Length: 1402
• Identity: 599/1402 - (42%)
• Similarity: 850/1402 - (60%)
• Gaps: 142/1402 - (10%)

  Fly    17 TIFSDAWCQYVSKQITATVYMYFAL-VMMSLLFI--AWFLYFKRMARLRLRDEIARSISTVTNSS 78
            |..|.....::.:...:|:.|...: |:::|.|:  |.|..:::::|.|..:...:
  Rat    17 TALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPTPQ--------- 72

  Fly    79 GDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSS-----GKGYKRRAVMRFARRILQLRRDNMP 138
                 .|||||||::||||:::||:..:...:..:     .:..||..|:..|:|||:.:::...
  Rat    73 -----YRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPT 132

  Fly   139 LEMRTVEPPAEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGD 199
            |:.:  |||...||..:...|    .:|.:.||||:::|:.||||||:||.||||...::|..|:
  Rat   133 LQPK--EPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGE 195

  Fly   200 YLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTA 264
            ::|:..:||.|:|:||.|.:.|.|.:|||:.:.:|.|..|:||.||||.:||::|:.:.||||:|
  Rat   196 HVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSA 260

  Fly   265 KAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMR--- 326
            :|...|.|:.||..||:.||:..|:.::||:|:||:|||||.|.||.|||||..||.....:
  Rat   261 RAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIP 325

  Fly   327 YKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSSPSRHSRE 391
            ..||::::|....|.|....:.....|. :|:.|         .|...||.|:.|        ..
  Rat   326 LLSVASVAGRAKRQMSYGPEEQLERSPR-LSEFN---------SSDQRSVAVSGP--------LL 372

  Fly   392 EHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSC 456
            :.:.|.|.|    ..||..:...:..|...|...| |:.|:.:..:|....:...::    .||.
  Rat   373 KRSCSVPLP----PIHGEIDELRQAQGSGSNTSAF-QESQEGATSDLGMAYNRARIL----PHSE 428

  Fly   457 LQTPGVTTSIDMRLV--QSSAV----DSLRKELGLSEEDSHII----EPFVELRELE-------- 503
            .|......|...:.|  ::|||    :..|.|.|.|.....|.    :..:.|.:|:
  Rat   429 EQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGR 493

  Fly   504 ------PNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAM 562
                  |..|::::....||.:.||::|.|.|||...|:.      .|..:...||||:||.||:
  Rat   494 VAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSL------EDTCLFLTHPGEMVGQLAV 552

  Fly   563 LTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLE 627
            ||||...:|||:........|.:|..|:|||:||.:||.:.:.||||:|..|||.|:||||:.:|
  Rat   553 LTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVE 617

  Fly   628 SGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVR 692
            :|||:|||.:.||.||||||||:||||....|||.:.||||:|||||:|||:|..:|.|||.|||
  Rat   618 AGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVR 682

  Fly   693 DSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEANPVTHKY----- 752
            ||||||||.|...:||.|||.|||:||..|..:.|||:|..||:   |..:..|..:.|:
  Rat   683 DSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGT---GHQLGFNTASSKWDLGNP 744

  Fly   753 ----STVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTSWLA 813
                ||||.:|::::||:|.|..||.|:|.||||||.||||.::::|||...::.:||||:|||.
  Rat   745 PGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLG 809

  Fly   814 QQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLY 878
            ||||.:.|.|||.||:|:.|||||:||||.||||||||:...:|:.|:.::..|:|.||:|:||:
  Rat   810 QQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLH 874

  Fly   879 PEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLAR 943
            .|...| |:.|:.|||.|.|.:.|.|:.|.:|:|:::|..::.::|:|:....|:.|||||||||
  Rat   875 KEEGPA-PSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLAR 938

  Fly   944 WLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAR 1008
            .||||:|.||||||||||.|.:|:|:|:.|.|||||::||.||||.||||:..||:.:.:..:|:
  Rat   939 ILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAK 1003

  Fly  1009 EWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHT 1073
            :|::.||.....:|||||||||||||..||.:|.:.|.|..|||||:|||.:|||||||..|:||
  Rat  1004 QWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHT 1068

  Fly  1074 NGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDL 1138
            :||||||||:||||||||||||||||||||:||||:|||||||..::||..:|||||||:|:|||
  Rat  1069 DGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDL 1133

  Fly  1139 TNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYK 1203
            |||||.|||||||:|:|||..:.|||.::.:||:|||||.||||||.|||||||||:|||||.|:
  Rat  1134 TNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYR 1198

  Fly  1204 TLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRF---NQWFNKEPPKRVNHASLNEYTFIDLAQI 1265
            ||.||.||||.:|||..|:..|:...::|.|.:.   .|..:|.  |.....:....:|.|||:|
  Rat  1199 TLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKR--KDCGVFTCPNSSFTDLAEI 1261

  Fly  1266 VCRLPETYAVNTAELFSEDEDCDGYISE--------PTTLNTDRRRIQVSRAGNSLSFSET--EM 1320
            |.|      :..|::.:.|::.| |.:|        |.....|              |..|  |:
  Rat  1262 VSR------IEPAKVAAVDDESD-YQTEYEEELPAIPKETYAD--------------FQSTGIEL 1305

  Fly  1321 DSDVELDLKLER-----KTDKSTQSSPPSNSRSDMRG 1352
            |||.|.:..:.:     .:.|.:|.|.|.....|.:|
  Rat  1306 DSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQG 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	CAP_ED	174..295	CDD:237999	55/120 (46%)
		Crp	484..>610	CDD:440428	46/143 (32%)
		CAP_ED	620..719	CDD:237999	65/98 (66%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	200/307 (65%)
Pnpla7	NP_653339.2	CAP_ED	170..291	CDD:237999	55/120 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..361		4/30 (13%)
		CAP_ED	478..588	CDD:237999	38/115 (33%)
		CAP_ED	601..709	CDD:237999	70/107 (65%)
		Involved in the binding to lipid droplets. /evidence=ECO:0000250|UniProtKB:A2AJ88	678..964		147/289 (51%)
		Pat_PNPLA6_PNPLA7	930..1235	CDD:132864	200/304 (66%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	951..956		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	978..982		2/3 (67%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	1100..1102		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1297..1349		14/60 (23%)