DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and Pnpla7

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	XP_036017642.1	Gene:	Pnpla7 / 241274	MGIID:	2385325	Length:	1384	Species:	Mus musculus

Alignment Length:	1448	Identity:	596/1448 - (41%)
Similarity:	848/1448 - (58%)	Gaps:	178/1448 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TIFSDAWCQYVSKQITATVYMYF---ALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSS 78
            |..|.....::.:|..:|:.|..   ||:.::.:.|.:|..::|:.|||..:...:
Mouse    17 TTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQ--------- 72

  Fly    79 GDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKG-----YKRRAVMRFARRILQLRRDNMP 138
                 .|||||||::||||:::||:..:...:..:...     .||..|:..|:|||:.:::...
Mouse    73 -----YRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPT 132

  Fly   139 LEMRTVEPPAEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGD 199
            |:.:  |||...||..:...|    .:|.:.||||:::|:.||||||:||.||||...::|..|:
Mouse   133 LQPK--EPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGE 195

  Fly   200 YLFKITDPDDSVYIVQSGMINVYISNA---DGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKT 261
            ::|:..:||.|:|:||.|.:.|.|.:|   ||:.:.:|.|..|:||.||||.:||::|:.:.|||
Mouse   196 HVFQPGEPDISIYVVQDGRLEVCIQDAVTQDGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKT 260

  Fly   262 VTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMR 326
            |:|:|...|.|:.||..||:.||:..|:.::||:|:||:|||||.|.||.|||||..||.....:
Mouse   261 VSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQ 325

  Fly   327 ---YKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSSPSRH 388
               ..||::::|       ::.||...||...: :.:|..|..|.:......|||:.|
Mouse   326 AIPLLSVASVAG-------RAKRQMSYGPEEQL-ERSLRPSEFSSSDHGSSCVTVSGP------- 375

  Fly   389 SREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQ----------------QHS--- 434
             ..:.:.|.|.|    |.||..:...:..|...|...|.:..:                .||
Mouse   376 -LLKRSCSVPLP----SNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQ 435

  Fly   435 VGN--LSTRRSSITLMAP-----------DGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELGLS 486
            :||  .|..:.|:....|           |.:.:|.:|..:..:....|:....:|
Mouse   436 LGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLD--------- 491

  Fly   487 EEDSHIIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFV 551
              |..:::..|....: |..||:::....||.:.||::|.|.|||...|:.      .|..:...
Mouse   492 --DPSLLDGRVAFLHV-PAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSL------EDTCLFLT 547

  Fly   552 HPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQ 616
            ||||:||.||:||||...:|||:........|.:|..|:|||:||.:||.:.:.||:|:|..|||
Mouse   548 HPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQ 612

  Fly   617 CDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITE 681
            .|:||||:.:|:|||:|||.:.||.||||||||:||||....|||.:.||||:|||||:||.:|.
Mouse   613 IDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTH 677

  Fly   682 TSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEAN 746
            .:|.|||.|||||||||||.|...:||.|||.|||:||..|..:.|||:|..|   |.|..:..|
Mouse   678 QARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGS---ATGHQLGFN 739

  Fly   747 PVTHKY---------STVALVPITDEVPMTPFTYELYHSLCAI--------GPVLRLTSDVVRKQ 794
            ..:.|:         ||||.:|.:::||:|.|..||.|:|.||        ||||.||||.::::
Mouse   740 TASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGKPQTCPEGPVLLLTSDNIKQR 804

  Fly   795 LGSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKF 859
            |||...::.:||||:|||.||||.:.|.|||.|.:|:.|||||:||||.|||||||::...||:.
Mouse   805 LGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGEL 869

  Fly   860 EREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLY 924
            |:.::..|:|.||:|:||:.| ....|:.|:.|||.|.|.:.|.|:.|.:|:|:::|..::.::|
Mouse   870 EQMLESTAVRAQKQLILLHKE-DGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMY 933

  Fly   925 SRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGAL 989
            :||....|:.|||||||||.||||:|.||||||||||.|.:|:|:|:.|.|:|||::||.||||.
Mouse   934 TRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAF 998

  Fly   990 MGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLW 1054
            ||||:..||:.:....:|::|::.||.....:|||||||||||||..||.:|.:.|.|..|||||
Mouse   999 MGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLW 1063

  Fly  1055 IPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHN 1119
            :|||.:|||||||..|:||:||||||||:||||||||||||||||||||:||||:|||||||..:
Mouse  1064 LPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARS 1128

  Fly  1120 LGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLE 1184
            :||..:|||||||:|:||||||||.|||||||:|:|||..:.|||.::.:||:|||||.||||||
Mouse  1129 MGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLE 1193

  Fly  1185 EVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRF---NQWFNKEPP 1246
            .|||||||||:|||||.|:||.||.||||.:|||..|:..|:...::|.|.:.   .|..:|.
Mouse  1194 MVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKR-- 1256

  Fly  1247 KRVNHASLNEYTFIDLAQIVCRL-PETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAG 1310
            |.....:....:|.|||:||.|: |...|.           .|..:...|.|.        .|..
Mouse  1257 KDCGVFTCPNSSFTDLAEIVSRIEPAKVAA-----------VDALLGTATVLG--------ERTN 1302

  Fly  1311 NSLSFSETEMDSDVE--------------------LDLKLERKTDKSTQSSPPSNSRSDMRGKEE 1355
            .:||.:..|.|...|                    ::|..:.:.:.|....|||     :...|:
Mouse  1303 GALSSALDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPS-----LTSPEQ 1362

  Fly  1356 ARHMSNWHWGVKHKDETG 1373
            ::....|   :.::|:.|
Mouse  1363 SQDSFPW---LPNQDDQG 1377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	68/144 (47%)
		CAP_ED	174..295	CDD:237999	55/123 (45%)
		Crp	483..>611	CDD:223736	44/127 (35%)
		CAP_ED	484..602	CDD:237999	41/117 (35%)
		CAP_ED	620..719	CDD:237999	64/98 (65%)
		Crp	624..>727	CDD:223736	63/102 (62%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	199/307 (65%)
		RssA	940..1222	CDD:224666	190/281 (68%)
Pnpla7	XP_036017642.1	CAP_ED	170..294	CDD:237999	55/123 (45%)
		CAP_ED	484..594	CDD:237999	41/127 (32%)
		CAP_ED	607..715	CDD:237999	69/107 (64%)
		Pat_PNPLA6_PNPLA7	944..1249	CDD:132864	199/304 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848578
Domainoid	1	1.000	250	1.000	Domainoid score	I2102
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62431
Inparanoid	1	1.050	1028	1.000	Inparanoid score	I275
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm43019
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770