DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and Prkar2b

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001351336.1	Gene:	Prkar2b / 19088	MGIID:	97760	Length:	416	Species:	Mus musculus

Alignment Length:	361	Identity:	77/361 - (21%)
Similarity:	130/361 - (36%)	Gaps:	91/361 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 SAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQ 428
            :|..|..|.||:. ...|..|.|.:..||....      .|:|            :||
Mouse    64 AAGGGIPSKGVNF-AEEPMRSDSENGEEEEAAE------AGAF------------NAP------- 102

  Fly   429 QQQQHSVGNLSTRRSSITLMA--PDGSHSCLQTPGVTTSID---MRLVQSSAVDSLRKELGLSEE 488
                  |.|..|||:|:...|  ||......::..:....|   .||.::.....|.|.|. .|:
Mouse   103 ------VINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLD-PEQ 160

  Fly   489 DSHIIEPFVELRELEPNVTLITEG-----NADDVCVWFVM-TGTLAVYQSNQDATRAKQDKSDML 547
            .|.:::...|        .|:.||     ..||...::|: .||..:|.......|.       :
Mouse   161 MSQVLDAMFE--------KLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC-------V 210

  Fly   548 IHFVHPGEIVGGLAMLTGEASAYTIRSRS------ITRIAFIRRAAIYQIMRQRPRIVLDLGNGV 606
            .::.:.|.. |.||::.....|.||.:.|      :.|:.| ||..:....::|     .:....
Mouse   211 GNYDNRGSF-GELALMYNTPRAATITATSPGALWGLDRVTF-RRIIVKNNAKKR-----KMYESF 268

  Fly   607 VRRLSPLVRQCDYA-----LDWI---FLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEI 663
            :..| |.::..:.:     :|.|   ....|..:..|.:.:||.:||.||.::..:...|  |..
Mouse   269 IESL-PFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKG--KSE 330

  Fly   664 VGEYG--------KGDLVGIVEMITETSRTTTVMAV 691
            |.|.|        :|...|.:.::|...|..:..|:
Mouse   331 VEENGAVEIARCFRGQYFGELALVTNKPRAASAHAI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	27/139 (19%)
		CAP_ED	484..602	CDD:237999	26/129 (20%)
		CAP_ED	620..719	CDD:237999	20/88 (23%)
		Crp	624..>727	CDD:223736	19/79 (24%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
Prkar2b	NP_001351336.1	Dimerization and phosphorylation	1..151		26/118 (22%)
		DD_RIIbeta_PKA	3..43	CDD:213051
		CAP_ED	152..265	CDD:237999	29/135 (21%)
		CAP_ED	274..394	CDD:237999	20/95 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900