DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sws and Prkar2a

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_032950.1	Gene:	Prkar2a / 19087	MGIID:	108025	Length:	402	Species:	Mus musculus

Alignment Length:	362	Identity:	76/362 - (20%)
Similarity:	131/362 - (36%)	Gaps:	113/362 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 SPSR-HSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITL 447
            ||:. |::|...:  |....||          |...|:.:|||      :..|.:..|||.|:
Mouse    54 SPTTFHTQESSAV--PVIEEDG----------ESDSDSEDADL------EVPVPSKFTRRVSV-- 98

  Fly   448 MAPDGSHSCLQT-----------PGV----TTSIDMRLVQSSAVDSLRKELGLSEEDSHIIEPFV 497
                    |.:|           |.|    |.....||.::.....|.|.|. .|:.|.:::...
Mouse    99 --------CAETFNPDEEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLD-QEQLSQVLDAMF 154

  Fly   498 ELRELEPNVTLITEGNADDVCVWFVM---TGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGG 559
            | :.::.:..:|.:|  ||...::|:   |..:.|.:.||..:..:.|.....          |.
Mouse   155 E-KIVKTDEHVIDQG--DDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSF----------GE 206

  Fly   560 LAML-----------TGEASAYTIRSRSITRI-------------AFIRRAAIYQI--MRQRPRI 598
            ||::           |.|.|.:.:...:..||             :||....:::.  |.:|.:|
Mouse   207 LALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKI 271

  Fly   599 VLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSG------RMRSVITHP 657
            |..:|..:.:                   .|..:..|.|.:||.||:.||      |.::.....
Mouse   272 VDVIGEKIYK-------------------DGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKN 317

  Fly   658 GGKKEI-VGEYGKGDLVGIVEMITETSRTTTVMAVRD 693
            ||.:|: :....||...|.:.::|...|..:..||.|
Mouse   318 GGNQEVEIAHCHKGQYFGELALVTNKPRAASAYAVGD 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736
		CAP_ED	174..295	CDD:237999
		Crp	483..>611	CDD:223736	29/156 (19%)
		CAP_ED	484..602	CDD:237999	27/146 (18%)
		CAP_ED	620..719	CDD:237999	21/81 (26%)
		Crp	624..>727	CDD:223736	21/77 (27%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
Prkar2a	NP_032950.1	DD_RIIalpha_PKA	4..44	CDD:213050
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84		7/33 (21%)
		CAP_ED	137..249	CDD:237999	24/125 (19%)
		CAP_ED	259..380	CDD:237999	26/115 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900