DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and M110.7

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_495734.3	Gene:	M110.7 / 187474	WormBaseID:	WBGene00010915	Length:	1095	Species:	Caenorhabditis elegans

Alignment Length:	1193	Identity:	366/1193 - (30%)
Similarity:	575/1193 - (48%)	Gaps:	199/1193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLE--ETI 155
            :||....||..|..|.:..:..|                 :||:.  |..:.:||.|..|  |..
Worm    66 IFYPISPLRHKKRSSKEEMTPDK-----------------KRDSS--EKISKQPPRELFEPNEQE 111

  Fly   156 EGSDRVPPDALYMLQSIRIFGHFEKPVFLRL-CKHTQLLELMAGDYLFKITDPDDSVYIVQSGMI 219
            :....:.|:..::|:::.   ..|.|...:| .|..:.|.:..|..:......:|.:.:|.||.:
Worm   112 QVPSHIKPEIFFVLKALE---GLELPTTWQLDPKDVETLSIDTGSVVLSPGRANDVIVVVISGEL 173

  Fly   220 NVYISNADGS---TLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFE 281
            .::.:.:.|.   ..::||:|.|||..|..|.|::|.......|.:..||:....|....:.:|.
Worm   174 GIFTNVSLGDKRYDCNIKTLRSGESYFSQTSIIEILMNEKPNNKYIHLKALTSCRVATYHLTSFH 238

  Fly   282 EVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQTSQSSR 346
            ..|..||...||.|||:|.|||:........|||:..:.:                     .:.|
Worm   239 TSFIANPQQWIRTIQVVMTRLQQCTLITCNMYLGIGGKCL---------------------NAKR 282

  Fly   347 QAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPNPNPDGSFHGTTN 411
            :.|:                                                    .|.|. ..|
Worm   283 KLPD----------------------------------------------------SGKFK-DFN 294

  Fly   412 LFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAV 476
            ..||.              :|.:.|                                       |
Worm   295 KLTEA--------------EQLNKG---------------------------------------V 306

  Fly   477 DSLRKELGLSEEDSHIIEPFVELRELEPNV-TLITEGNADDVCVWFVMTGTLAVYQSNQDATRAK 540
            :::.:.:|:.::...:.|   ::|:.|... |::||.|:.::.:.||:.|.|.:.:.:.:    .
Worm   307 EAIAQAMGIPDQSDKLRE---KVRKYECQAGTVVTEENSFEIDMIFVVFGKLRLKRGDLE----H 364

  Fly   541 QDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNG 605
            .|....|...|:||:::..:.:||.|.:..:.::...|....|.|....|.:...|.|.|.|...
Worm   365 DDTGTSLTFDVYPGDMLPSMQILTNEPAMCSAKALEKTIYFKICRDEYIQFLFAHPVIYLRLAFH 429

  Fly   606 VVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKG 670
            .::.:||..|..|.|:.|..:|:|:|::||.:.|||.:||:.||:|:|     ...:|:.|||:.
Worm   430 ALQFISPFARVFDMAVHWHRIETGQALFRQGDKSDSMHIVMGGRLRAV-----DSTKIIEEYGRL 489

  Fly   671 DLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSG 735
            ||:||.:|..:..|..||||||.|.:..:||.|.:.:|:|||.|..||:..:|..:
Worm   490 DLIGITDMAEKRPRRNTVMAVRFSHIVCIPENLLSFVKIRYPQVGNKLLKLISKCW--------- 545

  Fly   736 SGAPGAPVEANPVT---HKYSTVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGS 797
             .||.....::..|   ....|:|:||.:..||:|.||.|||:.|......|||:|.||.....|
Worm   546 -KAPTPETMSHVETTRNQNLRTIAIVPASRRVPLTEFTCELYNQLSKHVKTLRLSSSVVENYFES 609

  Fly   798 NIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRS---HLVGKF 859
            .:.....:|.|..||..||....:.|||||...:.||:||:|.||.||:|.||..|   .::.:.
Worm   610 EVITKKADYGLMHWLNVQEIAYSLVLYQCDFHKTNWTRRCLRMADAILMVALGTESKEEQVLAEA 674

  Fly   860 EREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFT---RKSQYRIN 921
            ....:...:|..||||.|:| .....|:.|.:|:. ..:.:.:||:....|:|:   :..:.:|.
Worm   675 LLSCNEKGVRQSKELVFLWP-IDTPTPSGTAAWIK-ESYYSGYHHLRAPNRLFSFPLKTREKKIV 737

  Fly   922 DLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSI 986
            :.|...:..|.:..||||||||.||||:||:|.||||||||||.|.|:|:.|..:.:|||||.||
Worm   738 EYYETTVYGEISYQSDFSRLARILTGNAIGIVFGGGGARGAAHAGALRALIEKKVQIDMVGGTSI 802

  Fly   987 GALMGALWCSERNITTVTQKAREWSKKMTKWFLQLL-DLTYPITSMFSGREFNKTIHDTFGDVSI 1050
            |||.|:|:.:..:|..|.:....::.::....|.:: |||:|...:.:|..||..:.....||:|
Worm   803 GALFGSLYATTPDIRAVGRMKDFFTDRLRNNILDVVRDLTWPYCGILTGHRFNLCVQRMLNDVNI 867

  Fly  1051 EDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPAD 1115
            ||.|:.:|.:|||:|:|..|||.||.:|..||||||::||:||:|||:||||||||.||||||||
Worm   868 EDCWVSFFCITTDLTSSSMRIHRNGIMWPVVRSSMSIAGYVPPICDPQDGHLLLDGAYVNNLPAD 932

  Fly  1116 VMHNLGAAHIIAIDVG-SQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSC 1179
            :|.:|||..:|||||| |.|:|:|.|||..:||.|.|:|:|.||...::|.::.::|:|||||.|
Worm   933 IMRSLGANVVIAIDVGMSDDNTNLRNYGFSISGTWCLFKRWWPFGEELRVLNMNEVQNRLAYVCC 997

  Fly  1180 VRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGK----NYFE-SMAKAGRLGRFNQ 1239
            |.|:|.|||:.||.|::.||:.:....|..||:...:||...|    .:|| |:|...:|....:
Worm   998 VNQMEIVKNAQYCYYVKLPIESFGIFDFSKFDQAAQIGYDITKQKMEEFFEDSVATRRKLLGCAR 1062

  Fly  1240 WFNKEPPKRVNHASLNEYTFIDL 1262
            ...:.|.|..|.   |..:|:::
Worm  1063 NVRQTPQKSKND---NILSFVNM 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	39/145 (27%)
		CAP_ED	174..295	CDD:237999	31/124 (25%)
		Crp	483..>611	CDD:223736	28/128 (22%)
		CAP_ED	484..602	CDD:237999	27/118 (23%)
		CAP_ED	620..719	CDD:237999	42/98 (43%)
		Crp	624..>727	CDD:223736	42/102 (41%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	153/311 (49%)
		RssA	940..1222	CDD:224666	143/283 (51%)
M110.7	NP_495734.3	CAP_ED	316..427	CDD:237999	26/117 (22%)
		Crp	325..>432	CDD:223736	26/110 (24%)
		Crp	423..>543	CDD:223736	49/124 (40%)
		CAP_ED	444..538	CDD:237999	42/98 (43%)
		Patatin_and_cPLA2	752..1040	CDD:299702	147/287 (51%)
		RssA	756..1046	CDD:224666	144/289 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I2665
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H62431
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2337
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm14479
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	O	PTHR14226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R845
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770