DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and ZK370.4

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_498927.2	Gene:	ZK370.4 / 176225	WormBaseID:	WBGene00022718	Length:	1353	Species:	Caenorhabditis elegans

Alignment Length:	1388	Identity:	466/1388 - (33%)
Similarity:	703/1388 - (50%)	Gaps:	260/1388 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RLRLRD---EIARSI------STVTNSSGDMRGLRF--------RKRDKMLFYGRRMLRKMKNVS 107
            |:|.||   ::.:|:      .|.|:.|.|......        |:|.|   :|....|:....
Worm   127 RMRKRDWAKKLYKSLVQDSPGRTPTDESSDEENANVVMGGGSVPRRRSK---HGNSSRRRQSTA- 187

  Fly   108 GQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEET--IEGSDRVPPDALYMLQ 170
               :...|...||....:.|:..:..:|.      .|.||.|:.|.|  .|....:.|:..|:|.
Worm   188 ---FQLAKDLIRRGSRSYFRQNQENNKDT------RVRPPQEFFEPTDLPEIPQNLQPEIFYILH 243

  Fly   171 SIRIFGHFEKPVFLRL-CKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLK 234
            ::::   .|.|...:| .:..::....||||:.|..:.||::|:...|.:.|:|.:.:|....:|
Worm   244 NLKM---LELPSEWKLDPREIEVRSFQAGDYIVKPGESDDAIYVAIDGELTVHIRHMEGKEYLVK 305

  Fly   235 TVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIM 299
            .:..|.|..||||.:|:|...||.::||..||.:...|.:.|:.:|.|.:..||:..||.||:::
Worm   306 CIPAGGSFFSLLSMLDILMDFPSIFRTVALKAADPCRVAKFPITSFRESYHKNPEAWIRPIQIVI 370

  Fly   300 IRLQRVLFTALRNYLGLNAELVQNHM---RYKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNL 361
            .||..|..|.|..|:||::||::...   |:::.|:.| .:....|...::.|         .|:
Worm   371 TRLLHVTLTTLHQYMGLSSELMRRRRDDDRHRNGSSTS-KLQLSLSLKKKEKP---------FNI 425

  Fly   362 MQSAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLF 426
                                                 |.|.............|..|
Worm   426 -------------------------------------NDNEQDQLIVARKWMAEAFG-------- 445

  Fly   427 HQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELGLSEEDSH 491
                                |:|.|                   |.|..:.|.
Worm   446 --------------------LVADD-------------------VVSEQIGSK------------ 459

  Fly   492 IIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQ------------SNQDATRAKQDKS 544
                 :.|...|....:|.:| |::..:..|:.|.|.:.|            |..|....::|:|
Worm   460 -----IHLESYEAGHVIIEQG-AEEEVLMMVLHGNLILAQYGSDFFAQIERESLFDEENNEEDES 518

  Fly   545 DMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRR 609
            .::  .|...|:||||.:||.|.|.||||:...||:|.:::......:...|.|.|.:.:.|:||
Worm   519 AVI--RVTARELVGGLQILTNEPSFYTIRAAVQTRVAIMKKKDFSAFLEAHPEIYLPVAHSVLRR 581

  Fly   610 LSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVG 674
            |||.:|..|:||||:.::||.|.||..:.:||.::|||||:|||     .||.:|.|:|:||::|
Worm   582 LSPFLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSV-----EKKTVVEEFGRGDVLG 641

  Fly   675 IVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAP 739
            ::|::|:..|.|||:|||.|:||::||||.|.||::||.|..:|:     :.||...:::...||
Worm   642 MMEVLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGFRLV-----QLLGQYYSQTNRRAP 701

  Fly   740 -GAPV--------EANPVTH--KYSTVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRK 793
             .||.        ..:|::|  ...|:|:||.:.:||:.|||.||||:|.:...||||:|..|..
Worm   702 FAAPTVIRTNELGATDPMSHIKNLHTIAVVPASPDVPLVPFTCELYHALSSNLRVLRLSSQKVAA 766

  Fly   794 QLGSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGK 858
            .|..::.|...::||..||..|||...:.:|:||.:.:.||:||:||||.||:|.:|.::.....
Worm   767 CLDPSVLEKQADFRLMHWLNVQEDTYPLVIYECDFTQTNWTRRCLRQADAILVVAIGGKTPEKQT 831

  Fly   859 FEREIDRL---AMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYR- 919
            ..||:..:   .:||.|||:||:|| |...|:.|:.||. ..:.:.|||:...||:.....::|
Worm   832 LMRELMNMNQDGVRTNKELILLWPE-STKTPSGTIEWLK-NSYFSGHHHIRAPKRMLQWNRKFRK 894

  Fly   920 ---------------INDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLK 969
                           :.:.|.:.:...|:..||||||||.||||:|||||||||||||||:|:|:
Worm   895 MSRAEVMTPTSVENEVIEYYEKNVFWTPDRRSDFSRLARILTGNAIGLVLGGGGARGAAHVGVLR 959

  Fly   970 AIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSG 1034
            |::|.|||||:|||.|||:|:|.|:....:...|..:|..|...|:..:.:||||||..::||:|
Worm   960 ALREEGIPVDIVGGTSIGSLIGGLYAETPDDVVVETRAASWFNGMSSLWRKLLDLTYAHSAMFTG 1024

  Fly  1035 REFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKD 1099
            .:||.:|.|.|.:..||||||.||.::|||:.|..|:|.:|.||.|.|:||||:||:||||||:|
Worm  1025 AQFNFSIKDLFEERLIEDLWISYFCISTDISTSEMRVHRSGPLWAYCRASMSLAGYLPPLCDPQD 1089

  Fly  1100 GHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKV 1164
            ||||||||||||:|||||.||||..:||.||||.::|:|.:|||.|||.|:|.|:.|||.:|.::
Worm  1090 GHLLLDGGYVNNVPADVMRNLGARCVIACDVGSIEETNLYDYGDSLSGMWVLLKRLNPFGTPPRI 1154

  Fly  1165 PDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFESMA 1229
            .::.:|||||||||||||||.||.:.||.|:||||:.:|||.|..|.||.::|..:|:.....:.
Worm  1155 LNMEEIQSRLAYVSCVRQLEVVKKASYCRYLRPPIEPFKTLDFPKFQEIMELGLKYGREACHELI 1219

  Fly  1230 ---KAGRLG--RFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCRLP-------ETYAVNTAE--- 1279
               :||.||  :..:.|.::..:|.........:|.|||..:.::|       .:.::|.:.
Worm  1220 TNDRAGILGDEKETRKFKRQQSRREKPDVSRAVSFTDLAAAMSKIPVVRPTLRHSMSLNPSANGP 1284

  Fly  1280 --------LFSED--EDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDSDVELDLKLERKT 1334
                    |..:|  .|.|.|..|.:.          |..||. ||:|.|       ||.:
Worm  1285 VGRAGDHFLLDDDLFNDTDYYEEESSQ----------SENGNE-SFTEDE-------DLVI---- 1327

  Fly  1335 DKSTQSSPPSNSRSDMRGKEEAR 1357
                  .|||:|.|.....|..|
Worm  1328 ------GPPSSSSSGGNVSENPR 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	45/142 (32%)
		CAP_ED	174..295	CDD:237999	38/121 (31%)
		Crp	483..>611	CDD:223736	36/139 (26%)
		CAP_ED	484..602	CDD:237999	33/129 (26%)
		CAP_ED	620..719	CDD:237999	49/98 (50%)
		Crp	624..>727	CDD:223736	46/102 (45%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	174/309 (56%)
		RssA	940..1222	CDD:224666	165/281 (59%)
ZK370.4	NP_498927.2	CAP_ED	261..364	CDD:237999	33/102 (32%)
		Crp	262..>377	CDD:223736	39/114 (34%)
		CAP_ED	449..570	CDD:237999	35/159 (22%)
		Crp	454..>583	CDD:223736	37/148 (25%)
		CAP_ED	578..686	CDD:237999	57/112 (51%)
		Crp	583..>700	CDD:223736	56/126 (44%)
		Patatin_and_cPLA2	926..1212	CDD:299702	169/285 (59%)
		RssA	950..1229	CDD:224666	151/278 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159617
Domainoid	1	1.000	210	1.000	Domainoid score	I1652
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62431
Inparanoid	1	1.050	738	1.000	Inparanoid score	I308
Isobase	1	0.950	-	0	Normalized mean entropy	S2337
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm14479
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R845
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890