DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sws and PNPLA6

DIOPT Version :9

Sequence 1:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001159583.1	Gene:	PNPLA6 / 10908	HGNCID:	16268	Length:	1375	Species:	Homo sapiens

Alignment Length:	1360	Identity:	574/1360 - (42%)
Similarity:	804/1360 - (59%)	Gaps:	147/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DVLEMLRASASGSYNTIFSDAWCQYVSKQITATVYMYFALVMMSLLFIAWFLYFKRMARLRLRDE 66
            |||    |...||...|.......:|.:.:...:....|:|:.::|.:.
Human    34 DVL----APGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILL---------------- 78

  Fly    67 IARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMR------- 124
            :.|.:......:.|....|||||||:|||||:::||:...:..:..:......|..||
Human    79 VVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLN 143

  Fly   125 FARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLR 185
            .|::||:::::...|:.:  |||...||..:...|    .:|.:.||||:::|:.||||||:||.
Human   144 IAKKILRIQKETPTLQRK--EPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLE 206

  Fly   186 LCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFID 250
            ||:|.....|..|||:|:...||.|:|:||.|::.:.:...||....:|.|..|:||.||||.:|
Human   207 LCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILD 271

  Fly   251 VLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLG 315
            |::|:....:||:|:|...|.|:|||::||..||...|:.::||:|:||:|||||.|.||.||||
Human   272 VITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLG 336

  Fly   316 LNAELVQNHMR------YKSVSTMSGP-------INSQTSQSSRQAPNGPPMVISQMNLMQSAVS 367
            |..||..:.::      ...:.|.:.|       :::..:...|:.|..||      :...:.:.
Human   337 LTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPP------DPTGAPLP 395

  Fly   368 GTGSSGVSVTVTRPPSSP--SRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQ- 429
            |.....|..|....||:|  ||      .:|.|     |...|...      |...:.|:.:::
Human   396 GPTGDPVKPTSLETPSAPLLSR------CVSMP-----GDISGLQG------GPRSDFDMAYERG 443

  Fly   430 ------QQQHSVGNLST----------------------RRSSITLMAPDGSHSCLQTPGVTTSI 466
                  |::.|.|:|:.                      ...|.|...|.|.:...||
Human   444 RISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQT------- 501

  Fly   467 DMRLVQSSAVDSLRKELG--LSEEDSHIIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAV 529
                  ||..::.::||.  :..||..::...|.|...:....:..:|: .||.:.||:.|.|.|
Human   502 ------SSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGD-QDVSLHFVLWGCLHV 559

  Fly   530 YQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQ 594
            ||      |......|:.:....|||:||.||:||||...:|:|::.......|.::..|:|||.
Human   560 YQ------RMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRA 618

  Fly   595 RPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGG 659
            :|.:||...:.|..|:||.|||.|:|:||..:|:|||:|||.:.||.|||||:||:||||....|
Human   619 QPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSG 683

  Fly   660 KKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSH 724
            |||:|||||:|||:|:||.:|...|.|||.||||:||||||||....||.|||.|||:||..||.
Human   684 KKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQ 748

  Fly   725 RFLGSMQ-------TRSGSGAPGAPVEANPVTHKYSTVALVPITDEVPMTPFTYELYHSLCAIGP 782
            :.||::|       ..||.|.|......||.:: .:|||::|:..||||..||.||.|:|.||||
Human   749 KILGNLQQLQGPFPAGSGLGVPPHSELTNPASN-LATVAILPVCAEVPMVAFTLELQHALQAIGP 812

  Fly   783 VLRLTSDVVRKQLGSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIV 847
            .|.|.||::|.:||::..::..|:||:.|||||||.:.|.|||.|:||:.||.||:||||.||||
Human   813 TLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIV 877

  Fly   848 GLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIF 912
            ||||:...:|:.|:.::..|:|..|:||||:.| ..|.|..|:.|||.|.|.:.|.|:.|.:|:|
Human   878 GLGDQEPTLGQLEQMLENTAVRALKQLVLLHRE-EGAGPTRTVEWLNMRSWCSGHLHLRCPRRLF 941

  Fly   913 TRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIP 977
            :|:|..::::||.:|.....:.|||||||||.||||:|.||||||||||.:|||:|||::|||:|
Human   942 SRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVP 1006

  Fly   978 VDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIH 1042
            ||:|||.|||:.:|||:..||:.:...|:||||:|.||.....:||||||:||||:|..||::||
Human  1007 VDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIH 1071

  Fly  1043 DTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGG 1107
            ..|.|..|||||:|||.:|||||||..|:|.:||||||||:||:||||:||||||||||||:|||
Human  1072 RVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGG 1136

  Fly  1108 YVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQS 1172
            |:||||||:..::||..:|||||||||:|||:.|||.|||||||:|:.||:...|||||:.:|||
Human  1137 YINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQS 1201

  Fly  1173 RLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGK---------NYFESM 1228
            ||||||||||||.||:|.||||:|||||.:||:.||.||:|.||||.:||         |..|.|
Human  1202 RLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKM 1266

  Fly  1229 AKAGRLGRFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCRL-PETYAVNTAELFSEDEDC 1287
            ....|....|:      .:|.:..:.....|.|||:||.|: |.|..|:......|:.||
Human  1267 LTDRRSTDLNE------SRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDC 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	Crp	168..>310	CDD:223736	65/141 (46%)
		CAP_ED	174..295	CDD:237999	52/120 (43%)
		Crp	483..>611	CDD:223736	40/129 (31%)
		CAP_ED	484..602	CDD:237999	37/119 (31%)
		CAP_ED	620..719	CDD:237999	63/98 (64%)
		Crp	624..>727	CDD:223736	64/102 (63%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	202/313 (65%)
		RssA	940..1222	CDD:224666	190/281 (68%)
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	52/120 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..436		19/106 (18%)
		Atrophin-1	<354..502	CDD:331285	30/183 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..472		4/22 (18%)
		CAP_ED	512..622	CDD:237999	36/116 (31%)
		CAP_ED	635..743	CDD:237999	69/107 (64%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864	200/304 (66%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	985..990		4/4 (100%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1012..1016		2/3 (67%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1134..1136		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1306..1375		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158195
Domainoid	1	1.000	250	1.000	Domainoid score	I2121
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1018	1.000	Inparanoid score	I281
Isobase	1	0.950	-	0	Normalized mean entropy	S2337
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm40949
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	O	PTHR14226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720