Protein Alignment sws and pnpla7

DIOPT Version :10

• Sequence 1: NP_511075.3
• Gene: sws / 31716
• FlyBaseID: FBgn0003656
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: NP_001090744.2
• Gene: pnpla7 / 100036730
• XenbaseID: XB-GENE-952941
• Length: 1339
• Species: Xenopus tropicalis
• Alignment Length: 1411
• Identity: 586/1411 - (41%)
• Similarity: 849/1411 - (60%)
• Gaps: 162/1411 - (11%)

  Fly    25 QYVSKQITATVY---MYFALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRF 86
            |:|..::..|::   :..|||.|:::.:..::.:|:..:.:             ....|:...||
 Frog    25 QFVEDRLQTTMWTGILIGALVAMAVIGVIGYIVYKKFRQSK-------------QPHSDVPRYRF 76

  Fly    87 RKRDKMLFYGRRMLRKM----KNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPP 147
            ||||||:||||:::||:    ..:.|...|..:..|:..|:..|:|||:.:::...|:.:  |||
 Frog    77 RKRDKMMFYGRKIMRKVTTLPNTLVGNAVSRPRTRKKPRVLSLAKRILRFKKEYPTLQKK--EPP 139

  Fly   148 AEYLEETIEGSD----RVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPD 208
            ...||..:...|    .:|.:.||||:::|:.||||||:||.||||...::|..|:|:|:....|
 Frog   140 PSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLHEGEYIFRPGQLD 204

  Fly   209 DSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVI 273
            :|:|:||.|.:.|.|..:||:.:.:|.|..|:||.||||.:||::|:.:.||||:|:|...|.::
 Frog   205 NSIYVVQDGTLEVCIQESDGADVVVKEVLAGDSVHSLLSILDVITGHTAPYKTVSARAATASTIL 269

  Fly   274 RLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNH------MRYKSVST 332
            |||..||::||...|:.::||:|:||:|||||.|.||.|||||..||..:.      :...|::.
 Frog   270 RLPANAFQDVFAKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNSESQAIPLLSVASLTV 334

  Fly   333 MSG---PINSQTSQSSRQAPNGPPMVISQMNLMQ--------SAVSGTG--SSGVSVTVTRPPSS 384
            .:|   .:..|.|..|.:..:|...:..|....|        |:..|.|  .|..|.::...|.|
 Frog   335 GAGGNKAVRRQVSSMSAEEEHGEKCIEQQPESDQGSLDPSKFSSTDGNGHKRSRSSSSIAEIPGS 399

  Fly   385 PS----------RHSREEHTLSDPNPNP--DGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGN 437
            |.          ..:|...|..|..|:|  :......:...||    .|:| ::|.:::.
 Frog   400 PKAAKSDMDMAYERARVSLTPDDMPPSPILNKPILKKSVTVTE----TPSA-VYHYKEED----- 454

  Fly   438 LSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELG--LSEEDSHIIEPFVELR 500
                     |:.|:            .|::..|  ::..::.:|:|.  :..:|..::...|.|.
 Frog   455 ---------LVIPE------------FSVNRHL--NAMFEAAKKDLSTLIKLQDPSLLNGRVTLH 496

  Fly   501 ELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTG 565
            :::....|..:|: .||.:.||::|.|.|||...|    :::::.:.|  .||||:||.||:|||
 Frog   497 QVKGGTILSRQGD-QDVNIRFVISGLLHVYQRKID----REEETCLFI--THPGELVGQLAVLTG 554

  Fly   566 EASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGR 630
            |...:||::........|.:...|:|||::|.:||.:.:.||:|:||.|||.|:||||:.:|:||
 Frog   555 EPLIFTIKANRDCTFLSISKCHFYEIMREQPSVVLGVAHTVVKRMSPFVRQIDFALDWMEVEAGR 619

  Fly   631 AVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSE 695
            |||||.:.||.|||||:||:||||....|||::.||||:|||:|:||.:|...|.|||.||||||
 Frog   620 AVYRQGDKSDCTYIVLNGRLRSVIRKDDGKKQLTGEYGRGDLIGVVEALTHQPRATTVHAVRDSE 684

  Fly   696 LAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPV---------------EA 745
            |||||||...:||.::|.|||:||..|..:.|||:|..:|      |:               .:
 Frog   685 LAKLPEGALTSIKRKFPQVVTRLIHLLGEKILGSLQQVNG------PLTGHGLGLHTTGNKWDSS 743

  Fly   746 NPVTHKYSTVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTS 810
            ||.:: .||||::|:::|||:|.|..||.|:|.|:||.|.||||.::::|||...::.:||||:|
 Frog   744 NPASN-LSTVAILPVSEEVPLTAFALELRHALGAVGPTLLLTSDNIKQRLGSAALDSVHEYRLSS 807

  Fly   811 WLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELV 875
            ||.||||.:.|.|||.|..|:.|||||:||||.|||||||::...||:.|:.::..|:|.||:||
 Frog   808 WLGQQEDIHRIVLYQSDYCLTPWTQRCIRQADCILIVGLGEQEPTVGELEKMLENTAVRAQKQLV 872

  Fly   876 LLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSR 940
            ||:.| ....|:.|:.|||.|.|.:.|.|:.|..|:|:::|..::.::|.||....|:.|.||||
 Frog   873 LLHKE-DGPPPSRTVEWLNMRSWCSGHLHLSCPHRVFSKRSLPKLIEMYERVSQKPPDRHCDFSR 936

  Fly   941 LARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQ 1005
            |||.||||:|.|:||||||||.:.:|::||:.|:|||:|:|||.||||.||||:..||:...:..
 Frog   937 LARVLTGNAIALILGGGGARGCSQVGIIKALIESGIPIDLVGGTSIGAFMGALYAEERSFNRMKI 1001

  Fly  1006 KAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHR 1070
            :||||...||..:.::||||||.||||||..|||:|...|.|..|||||||||.:|||||||..|
 Frog  1002 RAREWCMDMTSVWKKVLDLTYPTTSMFSGAAFNKSISSIFKDKQIEDLWIPYFNITTDITASAMR 1066

  Fly  1071 IHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDD 1135
            |||:|.||||||:||||||||||||||||||||:||||:|||||||..:|||..::||||||:|:
 Frog  1067 IHTDGCLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSLGAKVVLAIDVGSRDE 1131

  Fly  1136 TDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPID 1200
            ||||||||.|||||||:|:|||....|||.::.:||:|||||.||||||.|||.|||||||||||
 Frog  1132 TDLTNYGDALSGWWLLWKRWNPLADRVKVLNMAEIQTRLAYVCCVRQLEMVKNDDYCEYIRPPID 1196

  Fly  1201 KYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRFNQWFNKEPPKRVNHASLN---EYTFIDL 1262
            :|.||.||.||||.||||..||..|....::|.:.:..:  :::...:...:.:|   ..:|.||
 Frog  1197 RYGTLEFGKFDEICDVGYQHGKTVFNVWGRSGVIDKMLR--DRQETCKTKTSDINTCPNASFTDL 1259

  Fly  1263 AQIVCRLPETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDSDVELD 1327
            |:||.|:.   .|.||.:   |::.| |.:|     .:...|..|:..:.|:|...:.:.||
 Frog  1260 AEIVSRIE---PVKTAVV---DDESD-YQTE-----YEDEEIPDSQKEDYLNFLSAQNNGDV--- 1309

  Fly  1328 LKLERKTDKSTQSSPPSNSRSDMRGKEEARH--MSNWHWGVKHKDE 1371
                              |.||..|:...|.  .:.|..|:....|
 Frog  1310 ------------------SDSDEEGEMGVRQRPAAKWRQGMDRSQE 1337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sws	NP_511075.3	CAP_ED	174..295	CDD:237999	54/120 (45%)
		Crp	484..>610	CDD:440428	40/127 (31%)
		CAP_ED	620..719	CDD:237999	62/98 (63%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864	201/304 (66%)
pnpla7	NP_001090744.2	CAP_ED	170..291	CDD:237999	54/120 (45%)
		CAP_ED	484..587	CDD:237999	36/109 (33%)
		CAP_ED	600..708	CDD:237999	68/107 (64%)
		Pat_PNPLA6_PNPLA7	931..1236	CDD:132864	201/306 (66%)