Protein Alignment Ubr3 and UBR1

DIOPT Version :9

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_011700.1
• Gene: UBR1 / 853096
• SGDID: S000003416
• Length: 1950
• Species: Saccharomyces cerevisiae
• Alignment Length: 2326
• Identity: 403/2326 - (17%)
• Similarity: 712/2326 - (30%)
• Gaps: 823/2326 - (35%)

  Fly   134 SDDAGAKPSFFFGASSFSL-RSRKEVAALINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEW 197
            :|.:.|...|.:....|.: .|.:.:..|.|....:....|:|....|:| .....||.:.:.:.
Yeast    38 ADMSRALKEFIYRYLYFVISNSGENLPTLFNAHPKQKLSNPELTVFPDSL-EDAVDIDKITSQQT 101

  Fly   198 IRWLIAGGRTPQEFVKIVRSY--DNH----AKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKG 256
            |           .|.||..|.  |.|    ..||..:......|||..||......:|..||...
Yeast   102 I-----------PFYKIDESRIGDVHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPK 155

  Fly   257 NHTNHDF--NMFLSQAGGACDCGDTSVMKAEGFCSDHGINNRVNRDPVPN-------------NL 306
            :|.||..  ::......|.|||||.....:...|......|.::.||..|             |
Yeast   156 DHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKEEDVWNDSVN- 219

  Fly   307 LAVAEAIMPKLLFRLLQHFREH--------SDTPLEVQAITS----YSCEEFANMLIDLNNMGEI 359
            :|:.|.::.::....:..|.::        .|..::::.:|.    |...:|.|   ||....:.
Yeast   220 IALVELVLAEVFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLN---DLKYENDY 281

  Fly   360 MRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANREKYEDAVNRFPNPEPPDEYRDLPALGDKL 424
            |....|....:|.      .:|   ..:....|.:.|.|...:..       |||.:....
Yeast   282 MFDGTTTAKTSPS------NSP---EASPSLAKIDPENYTVIIYN-------DEYHNYSQA---- 326

  Fly   425 VHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIP----SVLEMSRDPD 485
              ||.|.:.:                    ||..:.:.||       |||.    ::|:.|:|..
Yeast   327 --TTALRQGV--------------------PDNVHIDLLT-------SRIDGEGRAMLKCSQDLS 362

  Fly   486 TLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFHFVID--- 547
            ::...  ..:||   ...|:..:.:....||.......::.    |.:.|:.||.:|.....
Yeast   363 SVLGG--FFAVQ---TNGLSATLTSWSEYLHQETCKYIILW----ITHCLNIPNSSFQTTFRNMM 418

  Fly   548 ----CTRQVMKDHC--YWPLVSD-FNNVLS----HESVALVFLRDDNLIDMWFQFLQMLQGMNVN 601
                |:..:....|  ..|:|.. |:|...    :..:.|..|.|.|.|.:
Yeast   419 GKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILADGNQIPL-------------- 469

  Fly   602 VRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHE--WLDS 664
                 .|.:..|           |:|.:.:..:|:.::..|..       .|..|.|..  :.|:
Yeast   470 -----GHHKILP-----------ESSTHSLSPLINDVETPTSR-------TYSNTRLQHILYFDN 511

  Fly   665 IYFMEARLSMEEMM-----QASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYL---LPLLMI 721
            .|:...|..::.::     .::.:.|:       .||.|.::   .|.:..|..|:   ..|..|
Yeast   512 RYWKRLRKDIQNVIIPTLASSNLYKPI-------FCQQVVEI---FNHITRSVAYMDREPQLTAI 566

  Fly   722 HPLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYF----FL 782
            ....||.|                                         .|.||....|    ||
Yeast   567 RECVVQLF-----------------------------------------TCPTNAKNIFENQSFL 590

  Fly   783 QNTIELFDVGQ-----------WLETAPLKQPQKAEQSSMLEGF-LTFLATLVTSRTNLGNDEAT 835
            .....:.|:.:           |         |:.::|::.:.: ::|...|.|..|.|
Yeast   591 DIVWSIIDIFKEFCKVEGGVLIW---------QRVQKSNLTKSYSISFKQGLYTVETLL------ 640

  Fly   836 QCIIEISALLATENKTHSQLLELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQGLFTPID 900
                         :|.|...:.|.|:.           .:..|::.|            ||   :
Yeast   641 -------------SKVHDPNIPLRPKE-----------IISLLTLCK------------LF---N 666

  Fly   901 EVWE-KHYDPLHVLLRAVHR-RDFQSSLDRFTNYV-----------KSKDKMPASGNLWPPFRLP 952
            ..|: |..:..|||    |. ::|.|.|:..|:..           ||||.:.:...|
Yeast   667 GAWKIKRKEGEHVL----HEDQNFISYLEYTTSIYSIIQTAEKVSEKSKDSIDSKLFL------- 720

  Fly   953 HALPATSSF-----------SDPCKILNSRIFH---------STILSIFFRAVHTRDVSEHL--- 994
            :|:...|||           .|..:::...:.|         .|:||.....|..:|..|.|
Yeast   721 NAIRIISSFLGNRSLTYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSLKDAYEALEDC 785

  Fly   995 ---LALAVFLLEIAVETSD-DVGSGTGDRAPPALAAVVESS---SGPGYHGYGTGRH-------- 1044
               |.::.|.|...|..|. |||....:    .::.:.::|   :.|....|....|
Yeast   786 SDFLKISDFSLRSVVLCSQIDVGFWVRN----GMSVLHQASYYKNNPELGSYSRDIHLNQLAILW 846

  Fly  1045 ---EPPKLF--------------------HCYPTDNLSCNLRHVVKKV--------------SLK 1072
               :.|::.                    |....|.:|..::..:..:              |||
Yeast   847 ERDDIPRIIYNILDRWELLDWFTGEVDYQHTVYEDKISFIIQQFIAFIYQILTERQYFKTFSSLK 911

  Fly  1073 SRDPQVITSSYRSNPFYSDLDFE--VEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQ 1135
            .|....|.:|...|.:...|.:.  :.:.|:    .:.:...|.|||
Yeast   912 DRRMDQIKNSIIYNLYMKPLSYSKLLRSVPD----YLTEDTTEFDEA------------------ 954

  Fly  1136 ALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLP 1200
                                :.|..|.:......|:    |...:..|..|.:|   ||:.:.|
Yeast   955 --------------------LEEVSVFVEPKGLADN----GVFKLKASLYAKVD---PLKLLNL- 991

  Fly  1201 ESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQP 1265
                                                     .||..|..|...|.:......:..
Yeast   992 -----------------------------------------ENEFESSATIIKSHLAKDKDEIAK 1015

  Fly  1266 VAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDES 1330
            |.:....::..:..:|:.. |:||...    ...::.|       :.:.:.:...       |.:
Yeast  1016 VVLIPQVSIKQLDKDALNL-GAFTRNT----VFAKVVY-------KLLQVCLDME-------DST 1061

  Fly  1331 ILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYK 1395
            .|:.||.|   :.|......|.:|:|...:...:..: || ...|:|.|:|...:|....|.:|
Yeast  1062 FLNELLHL---VHGIFRDDELINGKDSIPEAYLSKPI-CN-LLLSIANAKSDVFSESIVRKADY- 1120

  Fly  1396 NIHVSSSRIGDGPFFIGNLLRK-IAKQDEQCAQSIDDIRARLWPN--QREKQAEAKAREAKEKEE 1457
                              ||.| |.|:..:..:|:.......:.|  :.:|..:....:..|||.
Yeast  1121 ------------------LLEKMIMKKPNELFESLIASFGNQYVNDYKDKKLRQGVNLQETEKER 1167

  Fly  1458 RRKKARERQQKMMQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKEYDCIICNCTT 1522
            :|:.|::.|.:::..|.|:|..||:...:.     :..:|.|.:.:.|:....:::.|.:|.
Yeast  1168 KRRLAKKHQARLLAKFNNQQTKFMKEHESE-----FDEQDNDVDMVGEKVYESEDFTCALCQ--- 1224

  Fly  1523 PSTESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFG- 1586
               :|:.....|:..                    ..|.|.:.....:   || ..|.:.:..|
Yeast  1225 ---DSSSTDFFVIPA--------------------YHDHSPIFRPGNI---FN-PNEFMPMWDGF 1262

  Fly  1587 ----DESWYLSNNM---AYDNG------VHVQSCGHHVHLSCLEAYL-KTLYTTQRQPVQDRGEF 1637
                ::..|:.:::   ..:||      |.| ||.||:|.:|.:.|: |..:::        ..|
Yeast  1263 YNDDEKQAYIDDDVLEALKENGSCGSRKVFV-SCNHHIHHNCFKRYVQKKRFSS--------NAF 1318

  Fly  1638 YCPVCRQLSNSVLPLSP------------------QLDRPTHLVRSGNQPFERLVADLTDLIKEN 1684
            .||:|:..||..|||..                  .||..:.|.:...:...|.:..:..|:
Yeast  1319 ICPLCQTFSNCTLPLCQTSKANTGLSLDMFLESELSLDTLSRLFKPFTEENYRTINSIFSLM--- 1380

  Fly  1685 ETIPQPTKLTEAMG--HAMEVMTNIAQRKVKCSSITFRKLFIFVTSIARTNLEAEIIQR-----G 1742
                    :::..|  .|:....|.:.:.|.         .|.....|.|....||..|     .
Yeast  1381 --------ISQCQGFDKAVRKRANFSHKDVS---------LILSVHWANTISMLEIASRLEKPYS 1428

  Fly  1743 GSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVTATEPLPAHCLELIPS 1807
            .|...:...:||..:..:|.::                 .:..:.|.|....||.|..     |.
Yeast  1429 ISFFRSREQKYKTLKNILVCIM-----------------LFTFVIGKPSMEFEPYPQQ-----PD 1471

  Fly  1808 ILADPIAL---LLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGS 1869
            .:.:...|   :::..|.:|:.|.|     .|.........|.:......|:|.|  .:.|:|..
Yeast  1472 TVWNQNQLFQYIVRSALFSPVSLRQ-----TVTEALTTFSRQFLRDFLQGLSDAE--QVTKLYAK 1529

  Fly  1870 TSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTNDLVH--LRRDCIPST 1932
            .|...| ....|:|...|..|.::.|..|...:|.             ..||.:  |.:..:|:.
Yeast  1530 ASKIGD-VLKVSEQMLFALRTISDVRMEGLDSESI-------------IYDLAYTFLLKSLLPTI 1580

  Fly  1933 SSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLRVAALLRQH----- 1992
            ..                                            ||.|::|...|.:.
Yeast  1581 RR--------------------------------------------CLVFIKVLHELVKDSENET 1601

  Fly  1993 --LYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVR 2055
              :..||:.|    .|||          .|:.::    .:|.|..|...|:.:.
Yeast  1602 LVINGHEVEE----ELEF----------EDTAEF----VNKALKMITEKESLVD----------- 1637

  Fly  2056 PPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCY-------KVPKESS----- 2108
                     :|..|.|:...|.|..:|.||..:.........||.|       |:.:|.|
Yeast  1638 ---------LLTTQESIVSHPYLENIPYEYCGIIKLIDLSKYLNTYVTQSKEIKLREERSQHMKN 1693

  Fly  2109 --------ICLLCGTIVCLKQNCCAENDCCEAVRH-TLSCGGGIGIFLVVTSTYIIVIRGRRACL 2164
                    |||.||..|.|:.      |..|..:| ..:|....|.||:..|:.:        ||
Yeast  1694 ADNRLDFKICLTCGVKVHLRA------DRHEMTKHLNKNCFKPFGAFLMPNSSEV--------CL 1744

  Fly  2165 W----------GSLYLDDFDEEDRD-LKRGKPLYLSKDRFNLLESQWLSHK 2204
            .          .:.||:...|..|: ::||....|:..|:..|...|::::
Yeast  1745 HLTQPPSNIFISAPYLNSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNE 1795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	20/68 (29%)
		FliJ	<1410..1477	CDD:280262	16/69 (23%)
UBR1	NP_011700.1	ZnF_UBR1	121..193	CDD:197698	20/71 (28%)
		ClpS	308..>358	CDD:412656	16/89 (18%)
		RING_Ubox	1286..1332	CDD:418438	16/54 (30%)
		RING-H2 finger (C3H2C3-type)	1286..1323	CDD:319361	13/45 (29%)
		PRT6_C	1402..1793	CDD:408765	99/538 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21497
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030