Protein Alignment Ubr3 and UBR2

DIOPT Version :9

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_013124.1
• Gene: UBR2 / 850711
• SGDID: S000004014
• Length: 1872
• Species: Saccharomyces cerevisiae
• Alignment Length: 2266
• Identity: 394/2266 - (17%)
• Similarity: 738/2266 - (32%)
• Gaps: 790/2266 - (34%)

  Fly   219 DNHA--------KCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDF--NMFLSQAGGA 273
            |:|:        .|..:..|....|.|.||..:|...||..||.|..|.||.:  .:.:...|..
Yeast    85 DHHSVGNMHIGTACTRLCFPSETIYYCFTCSTNPLYEICELCFDKEKHVNHSYVAKVVMRPEGRI 149

  Fly   274 CDCGDTSVMK--AEGF-CSDHGINNRVNRDPVPN---------NLLAVAEAIMPKLLFRLLQHFR 326
            |.|||.....  ::.| |     .|.:|..|:.|         |::::...:: ..|..:...::
Yeast   150 CHCGDPFAFNDPSDAFKC-----KNELNNIPISNDNSNVTDDENVISLLNYVL-DFLIDVTVSYK 208

  Fly   327 EHSDTPLEVQAITSYSCEEFANMLIDLNN---MGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNG 388
            |.::         ::|.|..|:.|:..|.   ..:||.|.....|:|.|.:.||         :.
Yeast   209 EEAE---------AHSSERKASSLMHPNQNSITDDIMEKHECEPLVNDENFVFF---------DN 255

  Fly   389 RFLKANREKYEDAVNRFPNPEPPDEYRDLPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLL-- 451
            .:....:|.:.:...:....|....|.||.:...::::|. :|..|..|...|....:|..|.
Yeast   256 NWSNTRKEAHMEWAIQIEEEECNVHYMDLASTITRILNTP-VEYAISITKALEDSHDVVTVLQSE 319

  Fly   452 NMLP-DQDYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLL 515
            |... ||..||......|:|..:...:.:.....|        ::..|:   ||..|....|...
Yeast   320 NFFEIDQIAKEFQKENIVVHVRKADDIFKRKLTDD--------LTDWLY---SLCFKAATSLQNK 373

  Fly   516 HVMIISLKLM----MSKILIQNTLHDPNKNFH-------FVI---DCTRQVMKDHCYWPL--VSD 564
            :.:.||:..:    .||:.:..|  :.|.:|.       |:|   |......|.   |.|  :.|
Yeast   374 YALRISMLDVWYSHFSKMRVSPT--NTNPDFSKINLLGGFLISNEDSDESWFKP---WSLENIED 433

  Fly   565 --FNNVLSHESVALVFLRDDNLIDMWFQF----LQMLQGMNVNVRETASHVEFEPNSYYAAFSCE 623
              .:.:|::.:..|:.....|.:..::.|    .|.:...::|:....|..:.          .:
Yeast   434 ERISKILTNYNERLIRAHSPNTVSHFYNFYGSRFQYIIINSINILSKKSKFKM----------LK 488

  Fly   624 LEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLSMEEMM-QASFHFPLH 687
            :.||.:       .|:|.:...||.:.|:..::.|::.:.| ...|.::::..:: |.:|..|
Yeast   489 IMASLF-------SLRDESRKFLAAQYIDVYLSVLYDAVAS-DAKECQVTLMSILGQYTFQDP-- 543

  Fly   688 RYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVRNGLQIKGQAMTY 752
                     ::..|.||...:..:..:...|:..:|..:.|:....|     .||.::..:.:..
Yeast   544 ---------SIANMTISSGFIERTIRFAFTLMAFNPEDLMSYLPISL-----YNGFKLPTETIRN 594

  Fly   753 IQANFCNSMADMDLFFLQIC----ATNLPQYFFLQN------TIELFDVGQWLETAPLKQPQKAE 807
            .:...|         |..:|    |..:|:. .|.|      .||.|  .::....|||:..|..
Yeast   595 RRTIIC---------FKDLCTIMSANTVPEE-LLSNEAIFNAIIESF--SEFSNVLPLKRETKEH 647

  Fly   808 ---QSSMLEGFLTFLATLV------TSRTNLGNDEA--TQCIIEISALLAT---ENKTHSQLLEL 858
               ::.....|..|.::::      |...:|..|.|  .|.::::..:..|   |:.|:|:....
Yeast   648 VEVENFDFSAFYFFFSSILIMTDGYTRSISLVKDAAFRKQIVLKLLDVAQTREFESLTNSRKAIS 712

  Fly   859 MPERSGNVHTKN---FETFLKKLSVYKAPSSGSENLEQGL-----FTPIDEV------WEK--HY 907
            ....|.|.:..|   ..|..:.:..|.|.:.   |.:.|:     |.|:..:      |.:  .|
Yeast   713 PDNASTNENDSNKATLSTVRETICNYVAETI---NFQVGVNTQYFFNPMSYLFKFVIQWSQCGRY 774

  Fly   908 DPLHVLLRAVHRRDFQSSLDRFTNYVK----SKDKMPA-------------SGNLWPPFRLPHAL 955
            :|:...|               |||:.    .:||..|             .|.:...|.:.:..
Yeast   775 EPIPASL---------------TNYINLFEVFQDKQKALYISESALSTLVLIGQINVGFWVRNGT 824

  Fly   956 PAT------SSFSDPCKILNSRIFHSTILSI-FFRAVHTRD------------------------ 989
            |.|      :.:|     :....:.|.|.:: |..|:...|
Yeast   825 PITHQARMYTKYS-----MREFTYISDIFNVQFSMAMCNPDELMVTYLSRWGLKHWANGVPMYDY 884

  Fly   990 ---------VSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHE 1045
                     |:|.:|.|...|.|:                    .::|..||..|:.     |..
Yeast   885 PDTETTVAVVNECILLLIQLLTEV--------------------RSLVMKSSKEGFE-----RTF 924

  Fly  1046 PPKLFH--CYPTDN----LSCNLRHVVK----------------KVSLKSRDPQVITSSYRS--N 1086
            ..::.|  |:.|.:    ::|...|:.|                .|||......|:...|:.  :
Yeast   925 KSEIIHALCFDTCSYAQIVNCIPEHITKHPSFDIYLEKYANYTSPVSLTDNGIFVLKEKYKDEID 989

  Fly  1087 PFYSDLDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMR---------- 1141
            |:|..|......|.|:::|                 |.|....:.......||.:
Yeast   990 PYYIGLSSSRRYDVEKNIR-----------------LNMANLKKMKYEDTFVPAKKVKDLLKNTL 1037

  Fly  1142 VPGMEVALPPDLSVVAETGVVIRQDSNE------DDLLREGNHAMDMSPPAALDFHFPLQQITLP 1200
            ..|:.     .:|.|...|:.::...:.      |:||....|.:.
Yeast  1038 FSGLY-----SISSVNTFGLFLKNTLDHIIKYDYDNLLPRVVHLIH------------------- 1078

  Fly  1201 ESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQP 1265
                         |...||:                      ||..        |:|..
Yeast  1079 -------------LCVVNNL----------------------NEFM--------GILWH------ 1094

  Fly  1266 VAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDES 1330
                                                            :.||..:.....|...|
Yeast  1095 ------------------------------------------------EYAIVDTEFCHYHSIGS 1111

  Fly  1331 IL-SLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNY 1394
            || ..|||         |:||.|                                  .|:.:..:
Yeast  1112 ILYYCLLK---------DNFSES----------------------------------HGKIREIF 1133

  Fly  1395 KNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERR 1459
            :.:..::..:.     :.:.||      ||.......|   |||.:.:|       ..|:||..|
Yeast  1134 RYLMETAPHVN-----VNSYLR------EQTTSYTPGI---LWPTKEDK-------SHKDKEFER 1177

  Fly  1460 KK--ARERQQKMMQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKEYDCIICNCTT 1522
            ||  ||.|::|:|:..|.:|..||::.:..:|                             :.:|
Yeast  1178 KKHLARLRKKKLMKKLAQQQMKFMENNSVDTS-----------------------------DIST 1213

  Fly  1523 PSTESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTT------------------- 1568
            |.|.|..:.                     |..||||:.|...::.
Yeast  1214 PRTTSPSLS---------------------PTRINAENSSNTINSCCDDDCVFCKMPKDDDVFVY 1257

  Fly  1569 ---------------RLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVH---------VQSCGH 1609
                           ....:.||...|.|.|...:| .:..|...|:|..         :::|||
Yeast  1258 FSYQERNICDHGIDFTNPTDVNRINSLFSGKQTKDS-AIQENPQDDDGTRLKFTSCEPVLRACGH 1321

  Fly  1610 HVHLSCLEAYLKTLYTTQRQPVQD------RGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQ 1668
            ..|..||..::|::...|.|..::      .|..|||||..||||.||.:..:|:     |:.:|
Yeast  1322 GSHTKCLSGHMKSIRGIQNQTTKNIPLSYGSGLIYCPVCNSLSNSFLPKTNDIDK-----RTSSQ 1381

  Fly  1669 PFERLVADLTDLIKENETIPQPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKL-FIFVTSIART 1732
            .|       ..:.|.:|.......::.....|..::.::..:||......::.: .:|:.:|:.|
Yeast  1382 FF-------MCIEKRSEAEENLDPMSSICIKAAMILGDLQGKKVTTIEDAYKVVNSVFINTISNT 1439

  Fly  1733 NLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVL----SVHVRVLVEWPLWSS--------WAS 1785
            .|.....::.|.:  .|..|.  ..:||: .||::    |...:..|....:||        |..
Yeast  1440 ELRLRSHKKEGKI--VNMERI--SSQCIL-TLHLVCELKSFIYKKFVNSKTFSSEISRKIWNWNE 1499

  Fly  1786 LAGLPVTATEPLPAHCLELIPSILADPIALLL----KFILLAPLQLDQDYFTCMVKVMYNLLYYQ 1846
            ..                    |..:.:.|||    .|..:...:..|....|:.: |:...::|
Yeast  1500 FL--------------------IKGNNVNLLLYMSQNFDNIDGGKTPQPPNLCIYE-MFKRRFHQ 1543

  Fly  1847 IVVQLCVTLTDL----ECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRR----RAGQQQQS 1903
            :::.|...:..:    :|.:.:|:       |.|.:.|.....|....|..:.    :....:..
Yeast  1544 LLLLLARDMMRVNFYKDCRNKIKI-------SSNGSEEPSTSFSYLFNTFKKYVDLFKPDDVRFD 1601

  Fly  1904 SSQLGK-----------AMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAAT 1957
            .:.|.|           ::::...:|..|.:::.|          ....|.::...:|:
Yeast  1602 FTSLEKIKDFICSLLLESLSIFCRRTFLLFNIQYD----------DDGDGDNNNNRSNN------ 1650

  Fly  1958 ASSATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRH-EMPEISAPGLEFVRLVYYLELVTDS 2021
                   .:::|..|::|                 ::|: ::|.::    .|::..:|.||..:.
Yeast  1651 -------FMDVKQREIEL-----------------IFRYFKLPNLT----HFLKDFFYNELTQNI 1687

  Fly  2022 MDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQP---RLLELPR 2083
            ..::..|.:..:               ||::     .|.|:.   ||..: :..|   :|:|||.
Yeast  1688 ERYNDGNDNLRI---------------QQVI-----YDMVQN---INTRA-YPSPEHIQLIELPL 1728

  Fly  2084 EYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCA-----ENDCCEAVRHTLSCGGGI 2143
            ...: |:..::.....|.|.  |.::|||||. .|..|...|     :.:|.:.:|:........
Yeast  1729 NLSK-FSLDNDEISNKCDKY--EIAVCLLCGQ-KCHIQKSIALQGYLQGECTDHMRNGCEITSAY 1789

  Fly  2144 GIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQ 2199
            |:||:..:..|.:..|:|...:.:.||..:.|.:.|.|.|.|:||::.|:..|.::
Yeast  1790 GVFLMTGTNAIYLSYGKRGTFYAAPYLSKYGETNEDYKFGTPVYLNRARYANLANE 1845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	22/71 (31%)
		FliJ	<1410..1477	CDD:280262	21/68 (31%)
UBR2	NP_013124.1	ZnF_UBR1	96..171	CDD:197698	23/79 (29%)
		RING_Ubox	1314..1369	CDD:418438	19/54 (35%)
		PRT6_C	1434..1842	CDD:408765	90/512 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344455
Domainoid	1	1.000	156	1.000	Domainoid score	I886
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I823
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21497
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4143
TreeFam	0	0.000	Not matched by this tool.
	5	5.080