Protein Alignment Ubr3 and Ubr3

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_036018419.1
• Gene: Ubr3 / 68795
• MGIID: 1861100
• Length: 1904
• Species: Mus musculus
• Alignment Length: 2283
• Identity: 736/2283 - (32%)
• Similarity: 1073/2283 - (46%)
• Gaps: 551/2283 - (24%)

  Fly    98 SSVAAAAAPPPPPPRTGPTTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFSLRSRKEVAALI 162
            ::.|||...|.||....|    :.|.|.:..|.:|....|.::|....||.
Mouse     4 AAAAAAVGDPQPPQPEAP----AQGLALDKAATAAHLKAALSRPDNRAGAE-------------- 50

  Fly   163 NTECCRGSPTPDLDSIMDTLFNPGTPIDNL-------------------DNIEWIRWLIAGGRTP 208
                       :|.::::.:.|...|:...                   |.:||.:.|:|||...
Mouse    51 -----------ELQALLERVLNAERPLAGAAGGEEAAGGGGGGPGEAEEDALEWCKCLLAGGGGY 104

  Fly   209 QEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGA 273
            :||...||:||..|.|||||..:.|||||||||||||||:|.:||.:|:||.||||||.||||||
Mouse   105 EEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGA 169

  Fly   274 CDCGDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFRE-----HSDTPL 333
            |||||::||:..|||..|.|.:..|...||.:||.::|.::|:.:|.|:|:.||     .:|.|.
Mouse   170 CDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADAPS 234

  Fly   334 E------VQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVY----AFFMEAPCQDTRNG 388
            |      :|.:     |...:.|.||..||..||.|:|:.|.|.:.|    |...|..|
Mouse   235 EKDLNKVLQLL-----EPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTAGLGENAC------ 288

  Fly   389 RFLKANREKYEDAVN----RFPN-------PEPPDEYRDLPALG--------------------- 421
              .|.:.|||..|:.    .:|.       .||......|.|.|
Mouse   289 --AKKSHEKYLIALKSSGLTYPEDKLVYGVQEPAAGTSTLAAQGFAGATGTLGQIDSSDEEDQDG 351

  Fly   422 ----------------------DKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLT 464
                                  |.|.|.:.|||.:|||.|:||||.:|.|||||||||:||...|
Mouse   352 SQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFT 416

  Fly   465 RTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKI 529
            :|||.||:.|...|:.|.:.||:|||:||:||||||||.||.::..|..||.:|:..|..||...
Mouse   417 KTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESC 481

  Fly   530 LIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQM 594
            ||::.|.|...:.|.|::|...::|::.||||||||.|:|||:|||..||.|..|:..|..|:..
Mouse   482 LIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAQRFLEDHGLLVTWMNFVSF 546

  Fly   595 LQGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLH 659
            .||||:|.||...|||||..:|||||:.||||.|.|||.::||.:........:.::.||:..|.
Mouse   547 FQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQ 611

  Fly   660 EWLDSIYFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPL 724
            :|.|:|.|::.    ....|.:||.|||||.|.|:.:||....:.|:.:||.:..|:. ||||||
Mouse   612 DWFDAINFVDE----PAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSLLPDQEMLMK-LMIHPL 671

  Fly   725 RVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELF 789
            ::|:...||.:..|||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|.|
Mouse   672 QIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERF 736

  Fly   790 DVGQWLETAPLKQPQKAE---QSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATENKT 851
            .|...|..|........:   :.|||||.||||..|::.|.:||..:......|:.|.|...::|
Mouse   737 KVVDLLTMASQHHNMVLDVEHERSMLEGALTFLVILLSLRLHLGMSDDDILRAEMVAQLCMNDRT 801

  Fly   852 HSQLLELMPE----RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWEKHYD 908
            ||.||:|:||    :||.: .:.:||:.|..::.::||   ..||  ::||::||..|||::.:|
Mouse   802 HSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFRAPIFEPGGS--MQQGMYTPKAEVWDQEFD 864

  Fly   909 PLHVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIF 973
            |:.|:||.|:|||.||::||:|.::|...|.|  ||.|||::...:|  ..|:....::|:.:..
Mouse   865 PVMVILRTVYRRDVQSAMDRYTAFLKQSGKFP--GNPWPPYKKRTSL--HPSYKGLMRLLHCKTL 925

  Fly   974 HSTILSIFFRAV--HTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGY 1036
            |..:.::.::.:  | :::|||:|.:.::|:|:.:|.|.|..|..            |.|.|
Mouse   926 HIVLFTLLYKILMDH-QNLSEHVLCMVLYLIELGLENSADDDSEE------------EVSMG--- 974

  Fly  1037 HGYGTGRHEPPKLFH--CYPTDNLSCNLRHVVKKVSLK--------SRDPQVITSSYRSNPFYSD 1091
                     .|:..|  .:|..||..|:||.:..|.::        .|||...|||
Mouse   975 ---------GPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPELKRDPLASTSS--------- 1021

  Fly  1092 LDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRR-------NVSQALVPMRVPGMEVAL 1149
                   |...|::                      :|||       |...|.|
Mouse  1022 -------DALDSLQ----------------------NSRRPKVLQRENSGTAQV----------- 1046

  Fly  1150 PPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLL 1214
               .|:|||     |:...::.:.|..:.|               .|:..|:
Mouse  1047 ---FSLVAE-----RRKKFQEIINRSNSEA---------------NQVVRPK------------- 1075

  Fly  1215 AETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPS 1279
                                                                          :||
Mouse  1076 --------------------------------------------------------------IPS 1078

  Fly  1280 --NAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQL 1342
              :|.|:....|:.:                                |.:.|||||||:|||.:|
Mouse  1079 KWSAPGSSPQLTTAI--------------------------------LEIKESILSLLIKLHHKL 1111

  Fly  1343 SGTLDSFS---LSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRI 1404
            ||..:|:.   |.|.|                           .|.:....|.|:
Mouse  1112 SGKQNSYYPPWLDDIE---------------------------VLIQPEIPKYNH---------- 1139

  Fly  1405 GDGPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKM 1469
            |||...:..:|.|.|.|.....:.|::|..::.|....|:..|..::..:|||||:||||||||:
Mouse  1140 GDGITAVERILLKAAVQSRMNKRIIEEICRKVTPPVPPKKITAAEKKTLDKEERRQKARERQQKL 1204

  Fly  1470 MQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKE--YDCIICNCTTPSTESNPIGL 1532
            :.:||::||.||::|....|     ||::...|:...:|:..|  |||:||..:.||:|..|.||
Mouse  1205 LAEFASRQKSFMETAMDVDS-----PENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGL 1264

  Fly  1533 VVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMA 1597
            |||:::|.::|..|..||...||| ||:|......| .||..:.|..||...|.|.|..|:.::.
Mouse  1265 VVLLQASSVLGQCRDNAEPKKLPI-AEEEQIYPWDT-CAAVHDVRLSLLQRYFKDSSCLLAVSIG 1327

  Fly  1598 YDNGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQ----DRGEFYCPVCRQLSNSVLPLSPQLDR 1658
            ::.||:||:|||.:|:.|.::|:::|  ...|.:|    |:|||.||:|||.:|||||..|..:.
Mouse  1328 WEGGVYVQTCGHTLHIDCHKSYMESL--RNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNV 1390

  Fly  1659 PTHLVRSGNQPFERLVADLTDLIKENE-----------TIPQPTKLTEAMGHAMEVMTNIAQRKV 1712
            ..:|   ..:|..:   ...|||||.|           :|...|.|::.|...|:.:.|..|:|.
Mouse  1391 ENNL---WQRPCNK---STQDLIKEVEELQGRPGAFPVSISSETNLSKEMESVMKDIKNTTQKKY 1449

  Fly  1713 KCSSIT---FRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVL 1774
            :..|.|   ....|:|:.|:||||||.|:|.||||||:...:. ..||.|:..|.|||::|:|:.
Mouse  1450 RDYSKTPGSPDNEFLFMYSVARTNLELELIHRGGSLCSGGPST-AGKRSCLNQLFHVLALHMRLY 1513

  Fly  1775 VEWPLWSSWASLAGL------PVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFT 1833
            .....::.|..|..|      .|...:..|.     :|.:..|..:|||..||:.|..|.:::||
Mouse  1514 TIDSEYNPWKKLTQLVEDMNSQVGNEDQQPE-----VPILYHDVTSLLLIQILMMPQPLRKEHFT 1573

  Fly  1834 CMVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAG 1898
            |:|||::.|||.|.:..|.|..|:                .|.||               .:.||
Mouse  1574 CIVKVLFTLLYTQALAALSVKGTE----------------EDRSA---------------WKHAG 1607

  Fly  1899 QQQQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATT 1963
            ..::.:....|...::||                      ......|.....:...|...:..:.
Mouse  1608 ALRKDTCDAEKCYEVLLS----------------------FVISELSKGKLYYEEGAQECAMVSP 1650

  Fly  1964 IEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELV-----TD--- 2020
            |..:.:|||..:|..|||||||::||:.||:..::|...... ||..|...|.|:     ||
Mouse  1651 IAWSPESMERYIQDFCLPFLRVSSLLQHHLFGEDLPSCQEEE-EFSVLASCLGLLPTFYQTDHPF 1714

  Fly  2021 ----SMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVREL----VLINQHSLWQQPR 2077
                .:||            |.....:...||.::...     |.|..    .|:.|.|.|:.|.
Mouse  1715 ISASCLDW------------PVAAFDIITQWCFEITSF-----TERHAEQGKALLIQESRWKLPH 1762

  Fly  2078 LLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGGG 2142
            ||:||..|..:|.|||.:.|..|.||||:.::||:|||.||||..||.:...||.|.|:.:||.|
Mouse  1763 LLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCECVLHSQNCGAG 1827

  Fly  2143 IGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFAH 2207
            .||||::.::.||:|||.|.|||||:|||...||||||:||||||:.::|:.:||.||:||.|.|
Mouse  1828 TGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHTFDH 1892

  Fly  2208 TKHTWVFH 2215
            ....|..|
Mouse  1893 INKRWGPH 1900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	48/67 (72%)
		FliJ	<1410..1477	CDD:426581	24/66 (36%)
		RING-H2_UBR3	1601..1651	CDD:438146	25/53 (47%)
		PRT6_C	1722..2202	CDD:465944	167/501 (33%)
Ubr3	XP_036018419.1	UBR-box_UBR3	120..188	CDD:439071	48/67 (72%)
		RING-H2_UBR3	1331..1383	CDD:438146	20/51 (39%)
		PRT6_C	1441..1887	CDD:465944	137/469 (29%)