DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr3 and ubr3

DIOPT Version :9

Sequence 1:	NP_001259317.1	Gene:	Ubr3 / 31713	FlyBaseID:	FBgn0260970	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	XP_021334498.1	Gene:	ubr3 / 553247	ZFINID:	ZDB-GENE-030131-1473	Length:	1874	Species:	Danio rerio

Alignment Length:	2214	Identity:	717/2214 - (32%)
Similarity:	1059/2214 - (47%)	Gaps:	491/2214 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 ASSFSLRSRKEVAALINTECCR---GSPTPDLDSIMDTLFNP--GTPIDNLDNIEWIRWLIAGGR 206
            |:|...|.:|..||.:..:..|   .|....|..::|::.||  |:..:.||   |.:||:|||.
Zfish     3 AASLLRRDKKSTAAHLKADLKRTDNSSGLRQLQELLDSVLNPERGSDPEALD---WCKWLLAGGD 64

  Fly   207 TPQEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAG 271
            ...||.:.||||||...|||||..:.|||||||||||||||:|.:||..|:||.||||||.||||
Zfish    65 GFDEFCRTVRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFNNGDHTGHDFNMFRSQAG 129

  Fly   272 GACDCGDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFRE-----HSDT 331
            |||||||.:||:..|||:.|.:....|...||.:||.::|.::|:.:..::|:.|:     .|..
Zfish   130 GACDCGDGNVMRESGFCNRHRLKTGENVPSVPRDLLLMSEMVLPRFIITIIQYLRDGYTEPESAA 194

  Fly   332 PLEVQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANRE 396
            ..::|.:.. ..:...:.|.:|..||..||.|:|:.|.:.:.   |.|.......| .:.|.|.|
Zfish   195 DRDLQKVLQ-QLDPHISFLEELTKMGGAMRTVLTKILTDQQT---FKELSMGQEDN-VYAKKNYE 254

  Fly   397 KYEDA------------------------------------------VNRFPNPEPPDEYRDL-- 417
            ||..|                                          ::.....|..|..:.:
Zfish   255 KYLSALKSSGLVSVEEKGAAGGAGDGTSDAAAGAGALSLLGATATASLDDSSKEEDQDGLQGVGQ 319

  Fly   418 ------------PALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMH 470
                        |::.|.|.|...|||.:|||.|:||||.:|.||||||||||||...|:|||.|
Zfish   320 RKRVKLSSSTKDPSIMDTLKHKCFLEELLFWTIKYEFPQKMVTFLLNMLPDQDYKITFTKTFVQH 384

  Fly   471 YSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTL 535
            |:.|...|..|.:.||:|||:||:||||||||.||..:..|..||.:|:..|..||...||::.|
Zfish   385 YAFIMKTLMKSHESDTMSNRIVHISVQLFSNEELARHVTEECQLLDIMVTVLLYMMESCLIKSEL 449

  Fly   536 HDPNKNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNV 600
            .|...|.|.|::|...::|::.||||||||.|:|||:|||..||.|.:|:.:|..|:...||||:
Zfish   450 QDEENNRHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHSLLLLWMSFVSFFQGMNL 514

  Fly   601 NVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSI 665
            |.||...|||||..:|||||:.||||.|.|||.:::|.:........|.::.||:.||..|.|:|
Zfish   515 NKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLTHCKVKETQDYTKTVVRYCLETLQMWFDAI 579

  Fly   666 YFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFF 730
            .|::.    ..:.|.:||.|||||.|.|:.:.|...|:.|:.:||.:..|:. :|:|||::|:..
Zfish   580 GFVDE----PSLNQLTFHLPLHRYYAMFLSKGVKCQGLDLDSLLPDQEMLMK-IMVHPLQIQASL 639

  Fly   731 YEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWL 795
            .||.:..|||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|.|.|...|
Zfish   640 SEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLL 704

  Fly   796 ETAPLKQPQKA-----EQSSMLEGFLTFLATLVTSRTNLG--NDEATQCIIEISALLATENKTHS 853
            ..|  .|.|.|     ::..||||.||||..|.:.|.:||  :||..:.  |:.:.|...::|||
Zfish   705 TMA--SQHQNAVLDSEQERPMLEGALTFLVILCSLRIHLGMSDDEILRA--EMVSQLCMNDRTHS 765

  Fly   854 QLLELMPE----RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWEKHYDPL 910
            .||:|:||    :||.| .:.:||..|..::.:|||   ..||  ::||::||..|||||.:||:
Zfish   766 SLLDLIPENPNPKSGVVPGSCSFEEMLSGVADFKAPVFEPGGS--MQQGMYTPKAEVWEKEFDPI 828

  Fly   911 HVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHS 975
            .|:||.|:|||.||::||::.::|...  ..:||.|||::  ...|....:....::|:.:..|.
Zfish   829 MVILRTVYRRDVQSAMDRYSAFLKQSG--VHTGNPWPPYK--ERTPLHPCYKGLVRLLHCKTLHI 889

  Fly   976 TILSIFFRA-VHTRDVSEHLLALAVFLLEIAV--ETSDDVGSGTGDRAPPALAAVVESSSGPGYH 1037
            .|.::.::. :..:::|||:|.:.::|:|:.:  :..||               .||
Zfish   890 VIFTLLYKIWMDHQNMSEHVLCMVLYLIELGLDNQVQDD---------------KVE-------- 931

  Fly  1038 GYGTGRHEPPKLFHC----YPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEA 1098
                  .||....||    :|..:|..||.||:..|  :.|.|                    |.
Zfish   932 ------EEPCIEEHCHDSWFPGTSLLSNLHHVINFV--RVRVP--------------------ET 968

  Fly  1099 DPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRR-------NVSQALVPMRVPGMEVALPPDLSVV 1156
            .||...:...:.:.|...:|.......|..|||       |:.:|.|              .|:|
Zfish   969 APEVERKRERERERETPPSTSSESATFGQSSRRLTGNWRENLREAQV--------------FSLV 1019

  Fly  1157 AETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMG 1221
            ||.    |:...|  ::...||..
Zfish  1020 AER----RRKFQE--IINRSNHEA----------------------------------------- 1037

  Fly  1222 AIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGG 1286
                       :.|..|..:::....|.||.        |.|..:
Zfish  1038 -----------SQAVRPKSSASRWLPPGTPP--------QLVTEI-------------------- 1063

  Fly  1287 SFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSL 1351
                                                  |.:.||:||||:|||.:||...:|.||
Zfish  1064 --------------------------------------LEIRESMLSLLVKLHQKLSAKQNSLSL 1090

  Fly  1352 SDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLR 1416
            |                              .|||          :..:....|||...|..:|.
Zfish  1091 S------------------------------WLAE----------VDPAHHAHGDGLTAIERILA 1115

  Fly  1417 KIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFM 1481
            |.:.:.....:.:.:|..::.|....|:.....:::.:|||||::|||||||::.:||::||.||
Zfish  1116 KASARSRHSKRCLQEICGKVCPPIPPKKISPGDKKSMDKEERRQRARERQQKLLAEFASRQKSFM 1180

  Fly  1482 QSAAASSSGMGYGPEDEDDEELYEEQPREKE--YDCIICNCTTPSTESNPIGLVVLVESSGIVGH 1544
            ::|....|     ||.:...::..|:..:.|  |||:||..:.||||..|.|||||:::|.::||
Zfish  1181 ETAMDVES-----PEADAVMDVSSEESLDSEVLYDCVICGQSGPSTEDRPTGLVVLLQASSVLGH 1240

  Fly  1545 RRR--IAERLPLP----INAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVH 1603
            |.|  :.:|||..    |..||.....|..||:        |:...|.|.|...|.::.:|.||:
Zfish  1241 RCRSDMPKRLPTTDEEHIYPEDTCGATHDVRLS--------LMQRYFKDSSCLQSVSIGWDGGVY 1297

  Fly  1604 VQSCGHHVHLSCLEAYLKTLYTTQ-RQPVQ-DRGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSG 1666
            ||:|||.:|:.|.::|:::|...| .|.:. |:|||.||:|||.:|||||.     ||...:.:|
Zfish  1298 VQTCGHTLHIDCHKSYMESLRNDQVLQGISVDKGEFTCPLCRQFANSVLPC-----RPGRGMETG 1357

  Fly  1667 ------NQPFERLVADLTDL------------IKENETIPQPTKLTEAMGHAMEVMTNIAQRKVK 1713
                  .:....||.::.||            ||:.:.|...:.|::.|...::.:.|..|:|.
Zfish  1358 AWHAPSTKSMSTLVKEVEDLQEQLGIFPVRASIKQRDPILIESNLSKEMESVIKDIKNTTQKKY- 1421

  Fly  1714 CSSITFRKL-------FIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHV 1771
               :.:.|.       |:|:.|:||||||.|::.|||:||:..|:. ..||.|:..|.|||::|:
Zfish  1422 ---MDYGKNPGSPDNDFLFMYSVARTNLELELVHRGGNLCSGGASA-AAKRSCLNQLFHVLAMHM 1482

  Fly  1772 RVLVEWPLWSSWASLAGLPVTATEPLPAHCLE---LIPSILADPIALLLKFILLAPLQLDQDYFT 1833
            |:......::.|..|. |...:.|  ..:|.|   .:|.:..|..:||:.|||..|..|.:::||
Zfish  1483 RLYSIDSAYNPWTRLT-LSTQSRE--NEYCDEERPEVPMLFRDVPSLLIIFILTMPQPLRKEHFT 1544

  Fly  1834 CMVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAG 1898
            |:|||:|:|.:.|.:..|.:..:..|    ...:.:|.....|.....:..||..|
Zfish  1545 CVVKVLYSLQFTQALAALSIRFSREE----RLAWSNTGAAKKNLPNSDKSWESLLG--------- 1596

  Fly  1899 QQQQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATT 1963
               ...|:|.||               :|...:.|...:|.   |||..|.
Zfish  1597 ---HMISELTKA---------------KDVYDTNSEETSAL---SSSVWSP-------------- 1626

  Fly  1964 IEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGL----EFVRLVYYLELVTDSMDW 2024
                 :|:|.:||..||||||::.||:.|||..     |.||.    ||..|...|.|....
Zfish  1627 -----QSIEFRLQQFCLPFLRLSCLLQHHLYGD-----SLPGCLVEEEFSLLTRCLGLAASV--- 1678

  Fly  2025 DCFNA-SKGLCFIPGTETTLPQF-----WCQQLMEVRPPADT--VRELVLINQHSLWQQPRLLEL 2081
            .|..: |...|.    |..:..|     ||.:::.:   :||  .:...|:.|...|..||||:|
Zfish  1679 QCSGSMSSAACL----EWNISAFDLISQWCSEVVAL---SDTPSQQSASLLGQDPQWAAPRLLQL 1736

  Fly  2082 PREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIF 2146
            |..|..:|.|||.:.|.:|.|.||:.::||:||..||||.:||.:...||.|.|:..||...|||
Zfish  1737 PDNYNTIFQYYHRKSCSSCGKTPKDPALCLVCGAFVCLKGHCCKQQGVCECVLHSQHCGAATGIF 1801

  Fly  2147 LVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHT 2211
            |::.::.||:|||.|.|||||:|||...||||||:|||||||.::|:.:||.||::|.|.|....
Zfish  1802 LLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYLCEERYRVLEQQWVAHTFDHINKR 1866

  Fly  2212 WVFH 2215
            |..|
Zfish  1867 WGPH 1870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	48/66 (73%)
Ubr3	NP_001259317.1	FliJ	<1410..1477	CDD:280262	20/66 (30%)
ubr3	XP_021334498.1	zf-UBR	82..149	CDD:308042	48/66 (73%)
		RING-H2_UBR3	1209..1347	CDD:319397	60/145 (41%)
		RING-H2 finger (C3H2C3-type)	1211..1338	CDD:319397	52/134 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584100
Domainoid	1	1.000	946	1.000	Domainoid score	I37
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52092
Inparanoid	1	1.050	1099	1.000	Inparanoid score	I227
OMA	1	1.010	-	-		QHG60185
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0005748
OrthoInspector	1	1.000	-	-		oto38632
orthoMCL	1	0.900	-	-		OOG6_105451
Panther	1	1.100	-	-	LDO	PTHR21497
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910