Protein Alignment Ubr3 and Ubr2

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_038939744.1
• Gene: Ubr2 / 363188
• RGDID: 1593237
• Length: 1760
• Species: Rattus norvegicus
• Alignment Length: 2279
• Identity: 447/2279 - (19%)
• Similarity: 734/2279 - (32%)
• Gaps: 835/2279 - (36%)

  Fly   167 CRG-SPTPDLDSIM--DTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSYDNHAKCGLVW 228
            ||| :|.|..:..:  ..|..|            :.|.|.|......|.|:.::......||.|:
  Rat    51 CRGPNPFPQKEDTLAQHILLGP------------MEWYICGEDPALGFPKLEQANKPSHLCGRVF 103

  Fly   229 VPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDHGI 293
            ......|.||.|.:.|...:|..||....|.:|.:.|..|..||.||||||...|...:|..|.:
  Rat   104 KVGEPTYSCRDCAVDPTCVLCMQCFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQRHEL 168

  Fly   294 NNR---VNRDPVPNNLLAVAEAIMPK------LLFRL---LQHFREHSDTP--LEV-QAITSYSC 343
            ::.   ...||    |:.::|.::.:      ::||.   :..:.:.|:.|  ||| :...:|.|
  Rat   169 SSSEVVEEEDP----LVHLSEDVIARTYNIFAIMFRYAVDMLTWEKESELPEDLEVGEKTDTYYC 229

  Fly   344 EEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQD------TRNGRFLKANREK----- 397
            ..|.:.:.....:...::|.:..|  ..|...|   |...|      .|.|.|...::.|
  Rat   230 MLFNDEVHTYEQVIYTLQKAVNCT--QKEAIGF---ATTVDRDGRRSVRYGDFQYCDQAKTVIVR 289

  Fly   398 -------------------------------------YEDAVNRF----PNPEPPDEYRDLPALG 421
                                                 |.|.:.|.    ...|.||      ...
  Rat   290 NTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEGPD------GEN 348

  Fly   422 DKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIPSVLEMSRDPDT 486
            ..||...:|.:...|.........|  |:.::|.|..||:.....|..:|.::..  :...|...
  Rat   349 SSLVDRLMLNDSKLWKGARSVYHQL--FMSSLLMDLKYKKLFAVRFAKNYRQLQR--DFMEDDHE 409

  Fly   487 LSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLH-DPNKNFHFVIDCTR 550
            .:..|..:|||.|:..:||..::.|.:|:.|:|        |..:.:..| |....|.|......
  Rat   410 RAVSVTALSVQFFTAPTLARMLITEENLMTVII--------KAFMDHLKHRDAQGRFQFERYTAL 466

  Fly   551 QVMKDHCYWPLVSDFNNVLS------HESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHV 609
            |..|......|:.|...||.      .:.:...||:.   .|.:.:.|:.:|||:...|:...|:
  Rat   467 QAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQG---FDAFLELLKCMQGMDPITRQVGQHI 528

  Fly   610 EFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKII----NYCVTTLHE----WLD--- 663
            |.|| .:.|||:.:::     :..:||.:||  ...|.:|::    ..|:..|.:    :.|
  Rat   529 EMEP-EWEAAFTLQMK-----LTHVISMVQD--WCALDEKVLIEAYKKCLAVLMQCHGGFTDGEQ 585

  Fly   664 ---------SIYFMEARLSMEEMMQASFHFPLHRYLAAF-VCQAVTKMGISLNDVLPSRPYLLPL 718
                     |:..:...:|.|::   |.|.|:.|.||.. |..:.:::.....::||......|:
  Rat   586 PITLSICGHSVETIRYCVSQEKV---SIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPM 647

  Fly   719 LMIHPLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQ 783
            |:.||||......::.||.|.|||..:..|...|........|.|.|:..||...:.:....||.
  Rat   648 LIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDIVMLQTGVSMMDPNHFLM 712

  Fly   784 NTIELFDVGQWLETAPLKQPQKAEQSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATE 848
            ..:..|::.|
  Rat   713 IMLSRFELYQ------------------------------------------------------- 722

  Fly   849 NKTHSQLLELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQGLFTPIDEVWEKHYDPLHVL 913
                                           ::..|..|.
  Rat   723 -------------------------------IFSTPDYGK------------------------- 731

  Fly   914 LRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTIL 978
                          ||::.|..||.:..:..|
  Rat   732 --------------RFSSEVTHKDVVQQNNTL--------------------------------- 749

  Fly   979 SIFFRAVHTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGR 1043
                        .|.:|.|.:.|:              |:|..|          |.|..|
  Rat   750 ------------IEEMLYLIIMLV--------------GERFSP----------GVGQVG----- 773

  Fly  1044 HEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIG 1108
                      .||.:.   |.::.::|:|   |..          :|:|   |::.||...:..|
  Rat   774 ----------ATDEIK---REIIHQLSIK---PMA----------HSEL---VKSLPEDENKETG 809

  Fly  1109 QGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLL 1173
            .                     .:|.:.:...:.||:
  Rat   810 M---------------------ESVIETVAHFKKPGL---------------------------- 825

  Fly  1174 REGNHAMDMSPPAALDF-----HFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGANA 1233
             .|....::.|..|.:|     ||...:    :|..|.|.|:   |...|.            ..
  Rat   826 -TGRGMYELKPECAKEFNLYFYHFSRAE----QSKAEEAQRK---LKRENK------------ED 870

  Fly  1234 SATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNM-DIVPSNAMGAGGSFTSGVSGSGT 1297
            :|.||         |..|       ||       .|..|:: :|:..:.|         :|..||
  Rat   871 TALPP---------PALP-------PF-------CPLFGSLVNILQCDVM---------LSIMGT 903

  Fly  1298 GRRMNYETGGAR------KRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGED 1356
            ..:...|..|:.      :|.:.: ||.:.::|.|          .|.:.:.|.:.:|:.:....
  Rat   904 ILQWAVERHGSAWSESMLQRVLHL-IGMALQEEKH----------HLENAVEGHVQTFTFTQKIS 957

  Fly  1357 QSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQ 1421
            :..|..       |.:.:.:|..|:.         :|..::.|....|.    ::..:...|.|.
  Rat   958 KPGDAP-------NNSPSILAMLETL---------QNAPSLEVHKDMIR----WLLKMFNTIKKI 1002

  Fly  1422 DEQCAQS-IDDIRARLWPNQREKQAEAKAREAKEKEERRKK---ARERQQKMMQDFANKQK---- 1478
            .|..:.| :.:....:    .|:..|.|:...|:|.||::|   ||.|::|:|...:..|:
  Rat  1003 RESSSSSPVAEAEGAI----MEEVIENKSSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFID 1063

  Fly  1479 ----LFMQ--------SAAASSSGM-------GYGPEDEDDEELYEEQPREKEY-DCIICNCTTP 1523
                ||.|        |||..:|.:       ..||..       .:.|..::: .||:|.
  Rat  1064 ENKELFQQTIELDASASAALDNSPLVPDAALTALGPAQ-------TQVPEPRQFVTCILCQ---- 1117

  Fly  1524 STESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDE 1588
              |...    |.|||..:|                           ||| |.:|:.:||   .|.
  Rat  1118 --EEQE----VTVESRAMV---------------------------LAA-FVQRSTVLS---KDR 1145

  Fly  1589 SWYLSNNMAYDN---------GVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQ----------DR 1634
            |..:.:...||.         |.|..||||.:|..|.:.|..::...:::..|          :.
  Rat  1146 SKVIEDPEKYDPLFMHPDLSCGTHTGSCGHAMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVEN 1210

  Fly  1635 GEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQPFERLVADLTDLIKENETIPQPTKLTEAMGH 1699
            |||.||:|..|||:|:||.    .|...:.|....|    :|..||.:...||.|..|:.:.:..
  Rat  1211 GEFLCPLCECLSNTVIPLL----LPPRSILSRRLNF----SDQPDLAQWTRTIAQQIKVIQMLRK 1267

  Fly  1700 AMEVMTNIAQRKVKCSSIT-----FRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYK----- 1754
            ........:....:..:|.     ||..|.      ..|..::.|:.  .|.|.....||
  Rat  1268 GDSAADKPSSEDTEDMNIIPIPEGFRPDFY------PRNPYSDSIKE--MLTTFGTATYKVGLKV 1324

  Fly  1755 ------PKRECIVPLL------HVLSVHVRVLVEWPLWSSWASLAGLPVTATEPLPAH---CLEL 1804
                  |:    ||::      :.:....|:|.|          ...||..  |||..   ||..
  Rat  1325 HPNEDDPR----VPIMCWGTCAYTIQSIERILSE----------EEKPVFG--PLPCRLDDCLRS 1373

  Fly  1805 IPSILAD--PIALL--------LKFILLAPLQLDQDYFTCMVKV-MYNLLYYQIVVQLCVTLTDL 1858
            :....|.  .:|||        ..|..|.|....:| ..|::.: |::||     |.|.::...|
  Rat  1374 LTRFAAAHWTVALLPVVQGHFCKLFASLVPSDGSED-LPCILDIDMFHLL-----VGLVLSFPAL 1432

  Fly  1859 ECD---------------------HIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQ 1902
            :|.                     |||::. .||...:|                     |..|:
  Rat  1433 QCQDFSGSSLATGDLHIFHLVTLAHIVQIL-LTSCTEEN---------------------GMDQE 1475

  Fly  1903 SSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVN 1967
            :.:  |:....:||       |.:.....|.|:...:.:|.....|...|
  Rat  1476 NPT--GEEELAILS-------LHKTLHRCTGSALDEAPSGWHLWRSVRAG--------------- 1516

  Fly  1968 LKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAP-------GLEFVRLVYYLELVTDSM--- 2022
                       .||||:.:|     |:.|.:..:.||       ...|..|..||.|.|:.:
  Rat  1517 -----------ILPFLKCSA-----LFFHYLNGVPAPPDLQVSGASHFEHLCNYLSLPTNLIRLF 1565

  Fly  2023 --DWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQPR----LLEL 2081
              :.|..|             :|.:.|||. .||:        ..|..:......||    |::|
  Rat  1566 QENSDIMN-------------SLIESWCQN-SEVK--------RYLNGERGAISYPRGANKLIDL 1608

  Fly  2082 PREYERLFTYYHERPCLNCYKVPKES-------SICLLCGTIVCLKQNCC-AE---NDCCEAVRH 2135
            |.:|..|........|      ||..       ::||:||:::|.:..|| ||   .|......|
  Rat  1609 PEDYSSLINQASNFSC------PKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAH 1667

  Fly  2136 TLSCGGGIGIFLVVTSTYIIVIRGR-RACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQ 2199
            |.|||.|.||||.|....::.:.|: :.|.:...||||:.|.|:.|:||.||:|.::||..::..
  Rat  1668 TYSCGSGAGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKL 1732

  Fly  2200 WLSH 2203
            |..|
  Rat  1733 WQQH 1736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	25/67 (37%)
		FliJ	<1410..1477	CDD:426581	17/70 (24%)
		RING-H2_UBR3	1601..1651	CDD:438146	20/59 (34%)
		PRT6_C	1722..2202	CDD:465944	125/559 (22%)
Ubr2	XP_038939744.1	UBR-box_UBR2	98..167	CDD:439077	25/68 (37%)
		ClpS	222..300	CDD:460621	13/82 (16%)
		RING_Ubox	1112..1227	CDD:473075	40/155 (26%)
		PRT6_C	1315..1735	CDD:465944	120/531 (23%)