DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr3 and Ubr1

DIOPT Version :9

Sequence 1:	NP_001259317.1	Gene:	Ubr3 / 31713	FlyBaseID:	FBgn0260970	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster

Alignment Length:	2409	Identity:	461/2409 - (19%)
Similarity:	747/2409 - (31%)	Gaps:	911/2409 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 HDWDSSVAAAAAPPPPPPRTGP----TTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFSLRS 154
            :|.:..|.|     ||...:.|    .....:||...|.....|..::   |.:|...:|.:::.
  Fly     4 YDMEDVVVA-----PPAECSSPLKEWRLKRQAGTLDRSDIIEFLKRES---PKYFDYQTSATVKD 60

  Fly   155 RKEVAALINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSYD 219
            ...:     |..|....:...:.|:|.:               :.:::  |..|...::.:|...
  Fly    61 TNVI-----TLKCMFKESLAKEEIIDVV---------------VEFML--GDNPSSALEKLRLEG 103

  Fly   220 NHAK-CGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMK 283
            |.|. ||.|:......|.||.||:.|...:|.:|||:..|..|.:.|..|..||.|||||....|
  Fly   104 NTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWK 168

  Fly   284 AEGFCSDHGINNRVNRDPVPNNLL--AVAEAIMPKLLFRLLQHFREHSDTPLEVQAITSYSCEEF 346
            .:.:|..| :.||.|  |:.:.:|  ||.|.:  ::.|..:..|   ..:.||::...|..|
  Fly   169 KDQYCELH-LANRKN--PLESKILTDAVLERV--EICFGAILAF---CVSYLEIEPNASLQC--- 222

  Fly   347 ANMLIDLN-NMGEIMRKVMTRTLINPEVYAF-----------------FMEAPCQDTRNGR---- 389
                :|.| ..|::........|.|.|.:.|                 .||......|.||
  Fly   223 ----LDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVK 283

  Fly   390 ---FLKANREKYEDAVNRFPNPEPPDEYRDLPALGDKLVHTTLL-------------EEFI--FW 436
               |.:.|:.|.................|:..:|...::|...:             :||:  .:
  Fly   284 CDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRHY 348

  Fly   437 TFKFEFPQTL------------------------VCF----LLNMLPDQDYKEHLTRTFVMHYSR 473
            .|:..|.:.:                        .|:    :..||.:.|.|..|.:.|...|:.
  Fly   349 LFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYAT 413

  Fly   474 IPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNEL----SLLHVMIISLKLMMSKILIQNT 534
            |  |.:...|....:..:|.:|||||:..|:|..::...    .|||..   ..:.:.|.:...|
  Fly   414 I--VEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTF---YHVAIEKFIRNKT 473

  Fly   535 LHDPNKNFHFVIDCTR--QVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNL--IDMWFQFLQML 595
            ||. :||...:....|  .::.|..|  |:|...:|||::      ||:..|  .....:.|.::
  Fly   474 LHF-SKNIASLTFFKRANYILYDLRY--LLSLKPDVLSND------LRNGFLEGCRALMRVLNVM 529

  Fly   596 QGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHE 660
            |||....|:|..|:::||.                 |....:|    |..||..|     :.:.:
  Fly   530 QGMESMTRQTGQHMDYEPE-----------------WECAFNL----HIKLATTI-----SQVID 568

  Fly   661 W-------LDSIYFMEAR--------LSMEEMMQ--------------------ASFHFPLHRYL 690
            |       |..:|.|..|        :..|::||                    .|.|.||.|:.
  Fly   569 WASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFF 633

  Fly   691 AAFV----CQAVTKMGI-----SLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVRNGLQIK 746
            |...    ...:|..|:     :|:..|..|..:.|:|.     .|:...::.||.|.|||..:.
  Fly   634 AGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLC-----TQAMIAQVGAGLWRRNGYTLL 693

  Fly   747 GQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLE-------TAPLKQPQ 804
            .|...|........|.|.|:..|||.|:.:....||.:.:..|:...||:       :.......
  Fly   694 HQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDD 758

  Fly   805 KAEQSSMLEGFLTFLATLVTSRTNLGNDEATQ---CIIEISALLATENKTHSQLLELMPE-RSGN 865
            ...::|:.:.||..|..::..|...|....|:   ...||..||..:..:||:|...:|: .|||
  Fly   759 IIREASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGN 823

  Fly   866 VHTKN-FETFLKKLSVYKAP----SSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRRDFQSS 925
              :.| ||..:..::|:|.|    |.|...|::                 |:|      ::|...
  Fly   824 --SDNVFEEVINTVAVFKKPVGADSKGVYELKE-----------------HLL------KEFNMY 863

  Fly   926 LDRFTNYVKSK------DKMPASGNL--WPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFF 982
            ...:|...|||      ::..|...|  .||..||...||   |:....||...:|.:....|..
  Fly   864 FYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPA---FTPMANILQCPVFLNICSLIME 925

  Fly   983 RAV--HTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHE 1045
            ||:  ::|..:|..|...:.||..|::
  Fly   926 RALNAYSRSFTESHLQKVLHLLGYAIQ-------------------------------------- 952

  Fly  1046 PPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQG 1110
             .:|...||                        ..|.|..:..|..|: ::|
  Fly   953 -EELSEHYP------------------------FLSFYERSQEYGILE-KLE------------- 978

  Fly  1111 DPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLLRE 1175
                                               |:|..|
  Fly   979 -----------------------------------ELARCP------------------------ 984

  Fly  1176 GNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAG 1240
                       .|:.|:.....|:..
  Fly   985 -----------RLEAHYDFVLWTIER--------------------------------------- 999

  Fly  1241 ASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYET 1305
                               |:::|....||.|.          ||.|    .|..|||.::
  Fly  1000 -------------------FKQLQAKQAPSDGR----------AGPS----CSQQGTGGKL---- 1027

  Fly  1306 GGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCN 1370
                                                        |||
  Fly  1028 --------------------------------------------SLS------------------ 1030

  Fly  1371 EASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRAR 1435

  Fly  1031 ----------------------------------------------------------------- 1030

  Fly  1436 LWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAA---------ASSSGM 1491
                     ||.:|||  |:|.|.:.|.||:..:|......||.|:.|.|         ......
  Fly  1031 ---------AEEQARE--ERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTENETRKESA 1084

  Fly  1492 GYGPEDEDDEELYEEQ-------------PREKEY-------DCIIC--NCTTPSTESNPIGLVV 1534
            ..||.|.:|....|||             |..|.|       .||:|  ||....      |...
  Fly  1085 STGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISR------GGRQ 1143

  Fly  1535 LVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYD 1599
            ||.|:.:                  ..||:..||.     |.|..                   .
  Fly  1144 LVSSAFV------------------QTSRVIFTTP-----NLRNS-------------------Q 1166

  Fly  1600 NGVHVQSCGHHVHLSC-LEAYLKTLYTTQRQPVQDRG--------EFYCPVCRQLSNSVLPLS-- 1653
            :.:|:..|||.:|.|| ||.:....:...|:|.::|.        ||.||.||.|||:::|::
  Fly  1167 SALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTET 1231

  Fly  1654 -PQLDRPTHLVRSGNQ---PFERLVADLTDL------IKENE--TIPQPTKLTEAMG-------- 1698
             |....|.    |.|:   |.:..|..::.|      :|::|  |:|..:.:....|
  Fly  1232 LPAFSAPP----SPNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQF 1292

  Fly  1699 -HAMEVMTN------------------------IAQRKVK-----------------CSSITFRK 1721
             .:::::.|                        |.|..:|                 | |.|.:.
  Fly  1293 ERSVQLIKNPPRLHADYIEGIEFLKKALLNTMKIQQSHLKDHPAIESIEMVPILWDSC-SYTLQA 1356

  Fly  1722 LFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECI-----VPLLHVLSVHVRVLVEWPLWS 1781
            |.|::.::.:. |:||:..|..| |..|..|...:...:     :|||             |...
  Fly  1357 LEIYLYAVEKP-LKAELSMRHQS-CARNLVRACSRSSALEWETDLPLL-------------PPMR 1406

  Fly  1782 SWASLAGLPVTATEPLPAHCLELIPSILADPIALLLK---FILLAPLQL--------DQDYFTCM 1835
            |.|..:.              .|:.:|.......:|:   |.:|.|.|.        ::.|.|.:
  Fly  1407 SQAEFSS--------------RLLDTIFNQNDTSVLEWDCFRVLVPFQFGVLNLMVPEKGYKTII 1457

  Fly  1836 VK-VMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQ 1899
            .. .|::....|.:....:|...| |..:.|.....:..:.||  |..|.:..
  Fly  1458 PSGSMFDFYIMQTMFLAQLTKAVL-CFDVEKEKAKRAEKAPNS--ELTQLDYI------------ 1507

  Fly  1900 QQQSSSQLGKAMALVLSQTNDLVHLRRDCIPS--TSSSAAASAAGSSSTTSTNHGASAATASSAT 1962
             :|..|::         :.|.:...||..||:  ...:.........|..:..||.:......:.
  Fly  1508 -EQLPSRI---------RDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQGHGQTVVIPCESH 1562

  Fly  1963 TIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPE---ISAPGLEFVRLVYYLELVTDSM-- 2022
            .:.:.|:.::.|:.:    |||.:.|..:.|...:.|:   ...|. .|..:..||.|  |.|
  Fly  1563 HLALLLEYVQRQMSS----FLRCSCLFYRFLTDVDFPDTFPTDQPD-RFDLMCQYLGL--DPMLG 1620

  Fly  2023 ---DWDCFNASKGLCFI--PGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQPRLLELP 2082
               |.:...|:....|.  |..:..:.| .||      |.|          :.||..:|.|..||
  Fly  1621 VYFDMETVYATMMHSFASHPHIDREVEQ-RCQ------PDA----------RRSLQVEPCLRPLP 1668

  Fly  2083 R------EYERLFTYYHERPCLNCYKVP-KESSICLLCGTIVCLKQNCCAEN------DCCEAVR 2134
            |      ::..|.....:..|.|..:.. |..::||:||.|:|.:..||...      ..|  ..
  Fly  1669 RLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGAC--TH 1731

  Fly  2135 HTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQ 2199
            |..:||..:||||.:....::.:...:.|.....|||::.|.|..|:||.||.||:..:..:..|
  Fly  1732 HAHACGAEVGIFLRIRDCQVVYLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQ 1796

  Fly  2200 WLSH 2203
            ||.|
  Fly  1797 WLGH 1800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	26/66 (39%)
Ubr3	NP_001259317.1	FliJ	<1410..1477	CDD:280262	12/66 (18%)
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	26/66 (39%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	12/64 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21497
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950