DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr3 and ubr11

DIOPT Version :9

Sequence 1:	NP_001259317.1	Gene:	Ubr3 / 31713	FlyBaseID:	FBgn0260970	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	NP_594298.1	Gene:	ubr11 / 2542809	PomBaseID:	SPAC15A10.11	Length:	2052	Species:	Schizosaccharomyces pombe

Alignment Length:	2494	Identity:	456/2494 - (18%)
Similarity:	744/2494 - (29%)	Gaps:	1078/2494 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 CGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQA-GGACDCGDTSVMKAEGF 287
            ||.|:....|.|||:.||:.....:|..||...||..|:.::.:|.: .|.|||||......:..
pombe    98 CGHVFRAGEVIYRCKNCGLDNTCVLCAPCFHATNHEGHETHVSISTSYSGICDCGDPEAWNVDLN 162

  Fly   288 CSDHGI----------------------------------------------------------- 293
            |..|.:
pombe   163 CKIHNVPDDEEQKKPEEVIPLELQHSIRTTIHILLDFILDVFSCSPVNLKAQSTVGSILADEEAS 227

  Fly   294 ----------------------NNRVNR-DPVPNNLL---------------------------- 307
                                  |:.|:. |.|..::|
pombe   228 RLSSAKYGVADRPCNVFRVMLWNDEVHTFDAVVGSVLEALDSSNTAFGLEVAQRVDSIGRFAVAT 292

  Fly   308 --------AVAEAIMPKLL----------FR------LLQHFRE--------------------- 327
                    .:|.||..:.|          ||      ||:.|.:
pombe   293 SASVHEAIRIANAISKENLAVNVRTARDFFREDICGILLEWFDDLLESHVCYFADYLQIIVCDEI 357

  Fly   328 -----------------HSDTPLEV-----QAITSYSCEEFANMLIDLN---------NMG--EI 359
                             .::.|||:     .....|:.||..:::.:|.         |:|  |.
pombe   358 LKNWSPGLEKPAKPEVNFNNLPLEIVNDDDSEDDIYAAEELLDVIANLQDETGVTRIANLGGDED 422

  Fly   360 MRKVMTRTLINPEVYAFFMEAPCQDTRNGRFL---KANREKYED-------------------AV 402
            ....||    :|.:..|  :.|..|..:...|   :..||..:|                   .|
pombe   423 FEADMT----DPTIAGF--DHPLDDDNDVNDLLDFETEREDIDDLTDEVMETEENEAAEADYPGV 481

  Fly   403 NR------------------------------------FPNPEPPDEYRDL----PALGDKLVHT 427
            ||                                    .|.|.|....:|:    |....:|::.
pombe   482 NRNTRQDDVQDISMETESQNETDESQNTENVDYNPQTHTPVPIPTTATQDVVTIRPEFNSQLLNN 546

  Fly   428 TLLEEFI-------------------FW---------TFKF-EFPQTLV---CFLL--------- 451
              |.:.|                   :|         ::.| |.|.:::   .|||
pombe   547 --LRQIINARRRPRPAAVCQVSLREDYWKSPHPIPPSSYSFVESPSSILRLDYFLLFDLKFWKRL 609

  Fly   452 --------------NMLPDQDYKEHLTRTFVMHY-SRIPSVLEMSRDPDTLSNRVVHMSVQLFSN 501
                          |:|    :|..:...||:|| |...:.|...|:||   :.|:.:|||.|:.
pombe   610 RGLLSKLYVVPFNRNLL----FKRLMGIRFVIHYRSLATAFLFADREPD---HSVMFLSVQFFTT 667

  Fly   502 ESLALKMVNE---LSLLHVMIISLKLMMSKILIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVS 563
            .|||..:|.:   |:.|:...:||....::   .:||...:..:...|...|||:|....:.|.|
pombe   668 PSLAEAVVKDYDFLTNLNATTLSLLTQSNR---PSTLFSSDIEYTPTIQLNRQVLKTRRTYNLFS 729

  Fly   564 DFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHVEFE-PNS------------ 615
            |...:|.|..|..:.:.|...:..:...|::.||:....|...|||::: |:.
pombe   730 DLGYLLQHPQVKKLVVDDTRYVHQYIDLLRVFQGVIPQQRAILSHVQWDFPHGKNILFVMQRVAM 794

  Fly   616 ----------------YYAAFSCELEASAYPMWSI------ISHLQDGTHAHLAKKIINYCVT-- 656
                            .:.|..|.:.:..:|...|      :|.:...:..:..:.::.:.|:
pombe   795 LSNTVSSCFTQAPYERLFYAIKCIITSITHPKLDIAESLEPLSCIPSSSLTNFTQPLVPFSVSRD 859

  Fly   657 ------TLHEWLDSIYFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYL 715
                  .|| |:.|..|...|      :.||.|:.....||
pombe   860 PISFYHPLH-WMLSNLFSYCR------VDASSHWDKDTLLA------------------------ 893

  Fly   716 LPLLMIHPLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYF 780
               |:.|||||.....:|....|:|||..|......|.|.|......|.|:..:|.....:....
pombe   894 ---LLDHPLRVCVLLAQIDCNLWIRNGRSILLTDAFYRQLNNIEVSYDKDILAIQTILMFVDPNL 955

  Fly   781 FLQNTIELFDVGQWLETAPLKQPQKAEQS---SMLEGFLTFLATLVTSRTNLGNDEATQCI---- 838
            .|...::.|:...||......:....:..   :||...|..|..|:|.|..:.:.:....|
pombe   956 VLNAVVQRFEFTDWLYNLTYNEHPNYDTERIPAMLCKMLELLIALITEREQILHVDIQDIIRTRL 1020

  Fly   839 --------IEISALLATENKTHSQLLELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQ-G 894
                    :..||||:|   ..|.|:|.:          :|:...::::.||||    :.|.. |
pombe  1021 AQQLCFGPLAYSALLST---ISSNLVESL----------SFDKIREEVTSYKAP----DGLHDFG 1068

  Fly   895 LFTPIDEVWEKHYDPLHVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATS 959
            :::..||.::. .||.:.......|.:..:.|         |.::....|          :.|.|
pombe  1069 VYSLKDEYYDL-VDPYYFHYNKNEREESDTIL---------KKRLAKKNN----------VSAES 1113

  Fly   960 SFSDPCKILNSRIFHSTILSIFFRAVHTRDVSEHLLALAVF-LLEIAVETSDDVGSGTGDRAPPA 1023
            ...:| ||   |........|||.||:....|     |.:| .:|.|:..::..||
pombe  1114 IIIEP-KI---RFLEKDGHDIFFAAVNASTFS-----LIIFRAIEYALVQAESFGS--------- 1160

  Fly  1024 LAAVVESSSGPGYHGYGTGRHEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPF 1088
                  |..|....|                 |.|...|      :|:|      |....:||.|
pombe  1161 ------SDIGNTILG-----------------DALQLCL------ISMK------IHEFSKSNDF 1190

  Fly  1089 YSDLDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDL 1153
            .|                                        |:.::            ..|.|.
pombe  1191 CS----------------------------------------RSCAE------------RYPTDS 1203

  Fly  1154 SVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETN 1218
            |::.|.|       .....|.|...|: :..|...|.|.
pombe  1204 SIMREFG-------GSAYCLAELCFAI-LKSPKYKDVHV-------------------------- 1234

  Fly  1219 NMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMG 1283

pombe  1235 ----------------------------------------------------------------- 1234

  Fly  1284 AGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLK-LHSQLSGTLD 1347
                                        .|:..:.|..|:    |.|..|.:|: .|.:||.|
pombe  1235 ----------------------------KVNAVLAGLQKN----DPSAYSNMLEATHFELSTT-- 1265

  Fly  1348 SFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIG 1412
                      ||..||
pombe  1266 ----------SSTSDS------------------------------------------------- 1271

  Fly  1413 NLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQ 1477
                                                 .|.::.:|:::.|.|:|:|:||.|.::|
pombe  1272 -------------------------------------NEIEKTQEKKRLALEKQKKIMQQFRDQQ 1299

  Fly  1478 KLFMQSAAASSSGMGYGPEDEDDEELYEEQPRE--KEYDCIICNCTTPSTESN---PIGLVVLVE 1537
            ..|:    |.::....| ||:.::|:..|:|.|  |.::.|..||.....|.|   |.|::.:::
pombe  1300 ASFL----AQNTDFDIG-EDQTEDEVTTEEPEEEVKYHEHIRGNCLLCQEECNDQAPYGVIGIIQ 1359

  Fly  1538 SSGIVG----HRRRIAERL-PLPINAEDESRLAHTTRLAAE-----FNR-RTELLSLKFGDESWY 1591
            .|.::.    |...|.:.: .:|.|.:.||   |:.....:     ||| :..|||      ::.
pombe  1360 GSSLLRKTDVHSEIILDEIYSVPPNLDRES---HSRPFGKKYDTVVFNRSKDRLLS------AYP 1415

  Fly  1592 LSNNMAYDNGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQDRGEFY----------CPVCRQLS 1646
            ..||:   .||.|..|||.:||.|.:.|.......:........|:|          ||:||.||
pombe  1416 PGNNI---RGVFVSGCGHLMHLGCFKNYYVARSMYRNDVTAGLSEYYYKYSTAKFFMCPLCRSLS 1477

  Fly  1647 NSVLPLSPQLDR------PTHLVRSGNQPFERL----------------VADLTDLIKENETIPQ 1689
            |.:||: ||:.:      ..:..||.|...|.:                ::|..|..:.....|.
pombe  1478 NVLLPM-PQIPKMCLNIDTLNFPRSMNGWLEEIGTMSSSSFEYQLVRSSLSDTKDTFRSCFLRPW 1541

  Fly  1690 -PTKLTEAMGHAMEV-----------------------MTNIAQRKVKCSSITFRKLFIFVTSIA 1730
             .:|:..||...:::                       .|.:|.:.||.|:.|.......:.|:|
pombe  1542 INSKIISAMLARLKIADGALIDQSNNRDVSDLYDRYCETTKLAMKLVKGSTFTNVSPHDLLNSLA 1606

  Fly  1731 RTNLEAEIIQRGGSLCT---ANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVT 1792
            .|....|:.||    |:   :.|||               ||....|  .||     :|:.||..
pombe  1607 YTVSSLEVSQR----CSPKQSGATR---------------SVWFNEL--GPL-----TLSFLPTL 1645

  Fly  1793 ATEPLPAHCLELIPSILADPIALL------------------LKFILLAPLQLDQDY-------- 1831
            :...|...|.::|.|   |..|||                  ||.:|......|.|.
pombe  1646 SDTVLKCVCDQIIKS---DQQALLLMESQKLLVCKIFYRHSQLKSMLRNGRMSDHDQIQPFLLSN 1707

  Fly  1832 -FTCMVKV---------MYNLLYYQ---IVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQ 1883
             |...||:         ..|:|||.   .:.::|.|:..:     :||...:||..|.:...|||
pombe  1708 TFDDFVKISSLMLIFGKQDNILYYVKLFYLSEICKTIISM-----IKVVADSSVVPDLTINYSQQ 1767

  Fly  1884 QESA-----------AGTTNNRRRAGQQQQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAA 1937
            .:|.           .|::||..                  :|...::|:.|
pombe  1768 SKSQFYILCKNVLLWCGSSNNIE------------------ILDDESNLLRL------------- 1801

  Fly  1938 ASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEIS 2002
                                             |.| ::...|||||..||:   ||.  |.:||
pombe  1802 ---------------------------------MSL-VEKYSLPFLRRVALV---LYC--MFDIS 1827

  Fly  2003 APGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQF--------------WCQQLME 2053
               |||      .|...:..|.:....|| |..:|..:....|.              ||:.|.:
pombe  1828 ---LEF------NEFSNNEDDSELERLSK-LIKVPPLQELYSQMSSDENNQILELIAGWCEHLAQ 1882

  Fly  2054 VRPPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVC 2118
            ......|:.    :....:::   |::||...|.|.....|..|..|:|.|...:||:|||:::|
pombe  1883 NTWGDSTIS----LEYPGIYE---LVKLPHRLENLIDSMQESVCCMCHKTPILPAICMLCGSVIC 1940

  Fly  2119 L--KQNCCAENDCC-EAVRHTLSCGGGIGIFLVVTSTYIIVIR--GRRACLWGSLYLDDFDEEDR 2178
            .  :||..:..... |..:|..:|.|.:|||.:..:..|:::.  .....:..:.|||...|.|.
pombe  1941 FNARQNTVSSRRLTGECNKHAATCTGSVGIFFITKACGILLLDSISNTGTIMPTPYLDIHGETDL 2005

  Fly  2179 DLKRGKPLYLSKDRFN-LLESQWL 2201
            .|:||.|.:|::.|:: ::..|||
pombe  2006 QLRRGCPQFLNQKRYDFVVREQWL 2029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	23/67 (34%)
Ubr3	NP_001259317.1	FliJ	<1410..1477	CDD:280262	9/66 (14%)
ubr11	NP_594298.1	zf-UBR	98..166	CDD:280386	23/67 (34%)
ubr11	NP_594298.1	ClpS	244..>292	CDD:294604	5/47 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21497
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100