Protein Alignment Ubr3 and ubr-1

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_491231.2
• Gene: ubr-1 / 171953
• WormBaseID: WBGene00016326
• Length: 2058
• Species: Caenorhabditis elegans
• Alignment Length: 2521
• Identity: 439/2521 - (17%)
• Similarity: 732/2521 - (29%)
• Gaps: 1092/2521 - (43%)

  Fly   224 CGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGF- 287
            ||.|:....:.|.|..|.......:|..||:...|.:|.:.|..|...|.|||||.... .||:
 Worm    95 CGHVFKNGELTYTCLDCATDGTCVMCLQCFEVSIHKSHKYKMHSSSGSGYCDCGDADAW-TEGYA 158

  Fly   288 CSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTPLEVQAITSYSCEEFANMLID 352
            |::|     ..:|.....:||      |:|..|                      ||:...:::.
 Worm   159 CANH-----EKKDDEEAAVLA------PELKKR----------------------CEQLVEIILQ 190

  Fly   353 LN----------NMGEIMRKVMTR----------TLINPEVYAF------------------FME 379
            .:          .:.||..|:...          .|.|.|.:.:                  .:.
 Worm   191 FSLSMITHKDDLKLPEIFEKMKPEVTNEAQQYLTVLYNDETHTYESVIKVLELYIHCTKDQAMLV 255

  Fly   380 APCQDTRNGRFL-----KANREKYEDAVNRFPNPEPPDEYR----DLPALGDKLVHTTL--LEEF 433
            |...| |.||..     ||:..|.:|.|.|....:|....|    :|| |..|::.|||  |:.|
 Worm   256 ATIVD-REGRSAVKLGSKADCTKAKDDVQRKTARDPTSIRRSSNHNLP-LSVKVMDTTLFALQNF 318

  Fly   434 ----IFW--TFKFEFP-----------------------------QTLVCFLLN---MLPDQ--- 457
                :.|  |....||                             |.||..::.   :|||.
 Worm   319 SISLLTWLNTQMDVFPPLREIVGEILLSSKFALKKNYTRKMKSEDQRLVAGIIRNVMVLPDDEEE 383

  Fly   458 ----------------------------------------------------------------- 457
                                                                             
 Worm   384 ELFALDGRMDVDEMDDDDIGGEALQMEIDADDEEEITAALAGVSEHQESPGPSRDSSTFTMLENI 448

  Fly   458 ---------------------------DYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMS 495
                                       |.|....:.|::||:.|..  :..:|...:...||.:|
 Worm   449 LLQDTQMWKAGRSILHQMLMRTVFMIYDQKVRFAKAFMLHYNEIYE--DFIKDDHEMDVSVVGLS 511

  Fly   496 VQLFSNESLALKMVNELSLLHVMIISLKLMMSKIL---------------------IQNTLHDPN 539
            ||..:..|||.|:|.|.....|:..:::....|.:                     ::.:||
 Worm   512 VQFMTVPSLARKLVAEDQAFSVISKAIRDQTDKFVKYYNDGKIARFDFTSRSFPPELRRSLH--- 573

  Fly   540 KNFHFVIDCTRQVMKDHCY----WPLVSDFNNVLSHESVALVFLRDDNLIDMWFQ-------FLQ 593
                        :.:|..|    .|..||:|.               .|||.:.|       |||
 Worm   574 ------------ITRDMAYILNAVPSESDWNR---------------ELIDGFVQGFADFLLFLQ 611

  Fly   594 MLQGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDG---------THAHLAKK 649
            .||||:...|:...|..:| :.:..||            :|:..|:|.         |:..:..:
 Worm   612 HLQGMDEVKRQAVEHQVWE-SEWETAF------------NILLRLKDAISMIIGWAETNEEVHNR 663

  Fly   650 IINYCVTTL--------------HEWLDSIYFMEARLSMEEMMQA--SFHFPLHRYLA------- 691
            ::..|:..:              :|...:|.....|:|..:::::  |.|.|:.|.:|
 Worm   664 LMIMCLELMNRMPPVYTKSEEDTYELTVTINGESCRISHFDVLKSSTSVHQPVVRIIAGLFSASN 728

  Fly   692 --AFVCQAVTKMGISLN-----DVLPSRP----YLLPLLMIHPLRVQSFFYEILAGKWVRNGLQI 745
              .|:.........|||     :::..:.    |.|      .|||.....:..|..|.|||..:
 Worm   729 YTGFLLNRSNNSHTSLNQERIKELINCKDETNLYEL------SLRVLVLCAQSNATLWRRNGFSL 787

  Fly   746 KGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAPLKQ------PQ 804
            ..|...|......|.|.|.|:..:|:.|...|...|:.:.:..|.:.:| .|:..:|      |.
 Worm   788 INQIHNYFSPLCRNEMFDRDVLMMQVGAALTPSTKFIFHLLHRFRLFKW-ATSEFEQDKANEKPA 851

  Fly   805 KAEQSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATENKTHSQLLELMPERSGNVHTK 869
            |.| |..|...|..:|           :|..||:|    |:..|..|:.
 Worm   852 KPE-SEDLSKTLVMIA-----------EEFIQCLI----LILCERYTYG---------------- 884

  Fly   870 NFETFLKKLSVYKAPSSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRRDFQSSLDRFTNYVK 934
                                   .|...|:|::   ..:.:|:|....|  .|.....:.::.:.
 Worm   885 -----------------------VGKTRPMDQM---KREVIHILCTGSH--TFSHIQQKMSHDIN 921

  Fly   935 SKD-KMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTI--LSIFFRAVHTRDVS--EHL 994
            ||. .:..:.||...||.|   .||::....||       .|::  .|.||......|.|  |..
 Worm   922 SKRLSLHEAVNLVADFRKP---LATTAGQFHCK-------ESSLPTYSPFFMHYSKSDQSAAEQS 976

  Fly   995 LALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHEPPKLFHCYP---TD 1056
            .|.....:|.:|...          |||.|         |.:..:          |...|   |.
 Worm   977 QARVRAKMEKSVRAC----------APPIL---------PDFQTF----------FERIPEILTT 1012

  Fly  1057 NLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQGDPEGDEATGGA 1121
            |:   |.|||:         .:|..:.|.:.|.||..|      .:::.:||
 Worm  1013 NV---LIHVVR---------LIIDRTARRSRFSSDRLF------HKTLYLIG------------- 1046

  Fly  1122 GLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPA 1186
                                     :||                  ||::
 Worm  1047 -------------------------IAL------------------NEEE--------------- 1053

  Fly  1187 ALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTP 1251
                                                            ..|..|     |:....
 Worm  1054 ------------------------------------------------KNPSFG-----FTQRAE 1065

  Fly  1252 TGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIA 1316
            ...|:|                             |...|:.|..
 Worm  1066 ESIGLL-----------------------------SLLEGLVGKP-------------------- 1081

  Fly  1317 IGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAES 1381
                       :.||..:||::      |::.:
 Worm  1082 -----------ESSICPILLEV------TVEKY-------------------------------- 1097

  Fly  1382 TALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAE 1446
                                              ||:             |:||....:.....|
 Worm  1098 ----------------------------------RKL-------------IKARAGVPEAAPAPE 1115

  Fly  1447 AKAREAKE--KEERRKKARERQQKMMQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQ-P 1508
            .|..:::|  |.:|..:|.|.:||.|...:|.|..||:..             ||:|:..|.| |
 Worm  1116 NKPAQSEEEIKAKRAARAAEMRQKAMAKMSNMQSKFMKKI-------------EDEEKKDESQTP 1167

  Fly  1509 REK--------EYD-------------------------------------CIIC---NCTTPST 1525
            .||        :||                                     ||:|   ....|.
 Worm  1168 SEKSETVVKKDDYDNKHFFDEDVVKQVGHDFPVCIGANKWHAELVKPRTLTCILCQEDEIIAPQ- 1231

  Fly  1526 ESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESW 1590
            :..|:.....::.|.:..|:                             |:..||::...|..|.
 Worm  1232 QGKPMVCAAFIQQSQLFTHK-----------------------------NKNGELMTASSGTIST 1267

  Fly  1591 --YLSNNMAYDNGVHVQSCGHHVHLSCLEAYLKTLYTTQ----RQPVQ--------DRGEFYCPV 1641
              .|:.......||.|.:|.|.:|..|..:..:...:.:    ||..|        :.||:.||:
 Worm  1268 RDLLTAPATLQYGVDVSTCSHSMHYECYRSLAEANRSRESLRARQVGQHSHKMVDTENGEYQCPL 1332

  Fly  1642 CRQLSNSVLPLSP--QLDRP---THLVRSGNQPFERLVADLTDLIKENETIPQPTKLTEAMGHAM 1701
            |::|||:.:|:.|  ||...   :.:..:|.:.|:..||    .:|.|..:|..::.....||:
 Worm  1333 CKRLSNAAIPVLPAYQLTNQNGFSTVSGAGKENFDTWVA----RVKRNLEMPLSSESVSKKGHS- 1392

  Fly  1702 EVMTNIAQRKVKCSSITFRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPL--- 1763
                    ||...|..:...|..........|..|.::| .|::..::||......|..:.:
 Worm  1393 --------RKRSHSERSLLDLEKLSKDPDTANTSAGVLQ-FGAMEMSSATHMPASAESQMLMTTS 1448

  Fly  1764 -----LHVLSVHVRVLVEWPLWSSWASLAGLPVT----------------ATEPLPAHCLELIPS 1807
                 :...:....:.|:..: ::..|.|..|.|                ..:||.:....::.|
 Worm  1449 PSQDDVEFYNELAAMFVDQDV-NNTTSPAATPETIPAIGSSSRIPESQESGKKPLSSQIQHVLYS 1512

  Fly  1808 ILADPIALLLKFILLAPLQLD------QDYFTCMVK-------VMYNLLYYQIVVQLCVTLTDLE 1859
            ::. |...|:....:.....:      :|....|:|       :..|.:...:...:..|:|...
 Worm  1513 LIR-PFPALINSNRICSSSFEGFEEPIKDLGKNMMKFRKRGNELKTNFIEKHLKGYVISTVTWQS 1576

  Fly  1860 CDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTNDLVHL 1924
            ..|:.:..         |:.....::...|..|.|     |:...|.:.:..|.:......|:|.
 Worm  1577 TAHVARAI---------SSYLHYDKKPLFGALNTR-----QRDCLSAMARLCASLSHNMQFLLHA 1627

  Fly  1925 RRDCI-----------------------PSTSSSAAASA------------------AG------ 1942
            ..|.:                       |||||...|.|                  ||
 Worm  1628 VSDMLRVFLCEPPRPKLAQTPGSPLLSAPSTSSFTPAPAQIPHSGTNFAFLVQLFNPAGPRKNVN 1692

  Fly  1943 ----------------------------SSSTTSTNHGAS------------------------- 1954
                                        |.:::||:..|.
 Worm  1693 LNILQIDILSLAISLMMTIGWTWNNGTQSMNSSSTHQKARLLTPDGSVDEAYVLRLSLLAHYFQI 1757

  Fly  1955 AATASSATTIEVNLK-----SMEL---------QLQALCLPFLRVAALLRQHLYRHEMPEISAPG 2005
            .||.|.|...:||::     .||:         :|.|||.||  ...|.|..:...:|.|.:...
 Worm  1758 IATHSEADGNDVNMEEEQESQMEVDPVAAQTIRKLYALCHPF--DGPLRRVDILWRKMEEGAQSL 1820

  Fly  2006 LEFVRLVYYLELVTD---SMDWDCFNASKGLCFIPGTETTLPQ------------FWCQQLMEVR 2055
            |..:.|:|:...:.|   ::.....|:|:.|....|....:.:            .|...:
 Worm  1821 LRPIALLYHFITLVDPPEALKDPSINSSEPLFRYLGLPHKIEEQISGSMLEKLFTMWSSSI---- 1881

  Fly  2056 PPADTVRELVLINQHSLWQQPRLL-ELPREYERLFTYYHERPCLNCYKVPKESS------ICLLC 2113
             |:|......|:.|.   .:|.|| |||.:|.:|.   ::.....|..:|.|.|      :||:|
 Worm  1882 -PSDQALRQDLVVQP---VRPNLLVELPEKYSQLI---NQVATFKCPTIPIEESTSNVPTLCLVC 1939

  Fly  2114 GTIVCLKQNCCAE---NDCCEAVRHTLS-CGGGIGIFLVVTSTYIIVIRGR-RACLWGSLYLDDF 2173
            |||:|.:..||.:   .....|.|:.:| |.|.:|:||.|....::::..| |.|...:.|:|:|
 Worm  1940 GTILCSQAYCCQKIINKQSYGACRYHMSQCSGSVGMFLRVRDCSLVLMTTRKRGCFRPAPYVDEF 2004

  Fly  2174 DEEDRDLKRGKPLYLSKDRFNLLESQWLSH------------KFAHTKHTW 2212
            .|.|:..:||.||:|:.:.:..|:|.||..            .|.:.::.|
 Worm  2005 GEVDQGFRRGNPLHLNPELYQKLKSLWLQQGITEEVVNYNEIDFRNVQYDW 2055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	22/68 (32%)
		FliJ	<1410..1477	CDD:426581	16/68 (24%)
		RING-H2_UBR3	1601..1651	CDD:438146	18/61 (30%)
		PRT6_C	1722..2202	CDD:465944	125/657 (19%)
ubr-1	NP_491231.2	UBR-box_UBR1_like	94..163	CDD:439070	23/73 (32%)
		ClpS	217..305	CDD:460621	19/89 (21%)
		RING-H2_UBR1-like	1278..1342	CDD:438145	18/63 (29%)
		PRT6_C	1551..2033	CDD:465944	104/508 (20%)