Protein Alignment Ubr3 and UBR3

DIOPT Version :9

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_005246356.1
• Gene: UBR3 / 130507
• HGNCID: 30467
• Length: 1903
• Species: Homo sapiens
• Alignment Length: 2266
• Identity: 739/2266 - (32%)
• Similarity: 1079/2266 - (47%)
• Gaps: 517/2266 - (22%)

  Fly    99 SVAAAAA----PPPPPPRTGPTTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFS------LR 153
            :.|||||    .|..|....|      |.|.:..|.:|....|.::|....||....      |.
Human     2 AAAAAAAVGGQQPSQPELPAP------GLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLS 60

  Fly   154 SRKEVAALINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSY 218
            :.:.:||....|....:....         .||...:  :.:||.:.|:|||....||...||:|
Human    61 AERPLAAAAGGEDAAAAGGGG---------GPGAAEE--EALEWCKCLLAGGGGYDEFCAAVRAY 114

  Fly   219 DNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMK 283
            |..|.|||||..:.|||||||||||||||:|.:||.:|:||.||||||.|||||||||||::||:
Human   115 DPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMR 179

  Fly   284 AEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFRE-----HSDTPLE------VQA 337
            ..|||..|.|.:..|...||.:||.::|.::|:.:|.|:|:.||     .:|.|.|      :|.
Human   180 ESGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNKVLQL 244

  Fly   338 ITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNG----RFLKANREKY 398
            :     |...:.|.||..||..||.|:|:.|.|.:.|        :|..:|    ..:|.:.|||
Human   245 L-----EPQISFLEDLTKMGGAMRSVLTQVLTNQQNY--------KDLTSGLGENACVKKSHEKY 296

  Fly   399 ------------ED----------------AVNRF---------PNPEPPDEYRDLPALG----- 421
                        ||                ||..|         .:....|:......||
Human   297 LIALKSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKRV 361

  Fly   422 ------------DKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRI 474
                        |.|.|.:.|||.:|||.|:||||.:|.|||||||||:||...|:|||.||:.|
Human   362 KLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFVQHYAFI 426

  Fly   475 PSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPN 539
            ...|:.|.:.||:|||:||:||||||||.||.::..|..||.:|:..|..||...||::.|.|..
Human   427 MKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEE 491

  Fly   540 KNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRE 604
            .:.|.|::|...::|::.||||||||.|:|||:|||..||.|..|:..|..|:...||||:|.||
Human   492 NSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQGMNLNKRE 556

  Fly   605 TASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFME 669
            ...|||||..:|||||:.||||.|.|||.::||.:........:.::.||:..|.:|.|:|.|::
Human   557 LNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVD 621

  Fly   670 ARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEIL 734
            .    ....|.:||.|||||.|.|:.:||....:.|:.|||.:..|:. ||||||::|:...||.
Human   622 E----PAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQEMLMK-LMIHPLQIQASLAEIH 681

  Fly   735 AGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAP 799
            :..|||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|.|.|...|..|.
Human   682 SNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMAS 746

  Fly   800 LKQP---QKAEQSSMLEGFLTFLATLVTSRTNLG--NDEATQCIIEISALLATENKTHSQLLELM 859
            ..|.   ....:.|||||.||||..|::.|.:||  :||..:.  |:.|.|...::|||.||:|:
Human   747 QHQNTVLDAEHERSMLEGALTFLVILLSLRLHLGMSDDEILRA--EMVAQLCMNDRTHSSLLDLI 809

  Fly   860 PE----RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWEKHYDPLHVLLRA 916
            ||    :||.: .:.:||:.|..::.:|||   ..||  ::||::||..|||::.:||:.|:||.
Human   810 PENPNPKSGIIPGSYSFESVLSAVADFKAPVFEPGGS--MQQGMYTPKAEVWDQEFDPVMVILRT 872

  Fly   917 VHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIF 981
            |:|||.||::||:|.::|...|.|  ||.|||::...:|  ..|:....::|:.:..|..:.::.
Human   873 VYRRDVQSAMDRYTAFLKQSGKFP--GNPWPPYKKRTSL--HPSYKGLMRLLHCKTLHIVLFTLL 933

  Fly   982 FRAV--HTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRH 1044
            ::.:  | :::|||:|.:.::|:|:.:|.|.:..|..            |:|.|
Human   934 YKILMDH-QNLSEHVLCMVLYLIELGLENSAEEESDE------------EASVG----------- 974

  Fly  1045 EPPKLFH--CYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMI 1107
             .|:..|  .:|..||..|:||.:..|  :.|.|:......|.:|
Human   975 -GPERCHDSWFPGSNLVSNMRHFINYV--RVRVPETAPEVKRDSP-------------------- 1016

  Fly  1108 GQGDPEGDEATGGAGLGMGAHSRR-------NVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQ 1165
                    .:|....||....|||       |...|.|              .|:|||     |:
Human  1017 --------ASTSSDNLGSLQSSRRPKVLQRENSGTAQV--------------FSLVAE-----RR 1054

  Fly  1166 DSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGG 1230
            ...::.:.|..:.|
Human  1055 KKFQEIINRSSSEA--------------------------------------------------- 1068

  Fly  1231 ANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGS 1295
                        |::..|.|.:                         ..:|.|:....|:.:
Human  1069 ------------NQVVRPKTSS-------------------------KWSAPGSAPQLTTAI--- 1093

  Fly  1296 GTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFS---LSDGEDQ 1357
                                         |.:.|||||||:|||.:|||..:|:.   |.|.|
Human  1094 -----------------------------LEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIE-- 1127

  Fly  1358 SSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQD 1422
                                     .|.:....|.::          |||...:..:|.|.|.|.
Human  1128 -------------------------ILIQPEIPKYSH----------GDGITAVERILLKAASQS 1157

  Fly  1423 EQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAAS 1487
            ....:.|::|..::.|....|:..|..::..:|||||:||||||||::.:||::||.||::|...
Human  1158 RMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMETAMDV 1222

  Fly  1488 SSGMGYGPEDEDDEELYEEQPREKE--YDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIAE 1550
            .|     ||::...|:...:|:..|  |||:||..:.||:|..|.|||||:::|.::|..|...|
Human  1223 DS-----PENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQCRDNVE 1282

  Fly  1551 RLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHHVHLSC 1615
            ...|||:  :|.::......||..:.|..||...|.|.|..|:.::.::.||:||:|||.:|:.|
Human  1283 PKKLPIS--EEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGGVYVQTCGHTLHIDC 1345

  Fly  1616 LEAYLKTLYTTQRQPVQ----DRGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQPFER-LVA 1675
            .::|:::|  ...|.:|    |:|||.||:|||.:|||||..|..:       ..|.|::| ...
Human  1346 HKSYMESL--RNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSN-------VENNPWQRPSNK 1401

  Fly  1676 DLTDLIKENE-----------TIPQPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKL---FIFV 1726
            .:.|||||.|           :|...|.|::.|...|:.:.|..|:|.:..|.|....   |:|:
Human  1402 SIQDLIKEVEELQGRPGAFPVSISSETNLSKEMESVMKDIKNTTQKKYRDYSKTPGSPDNDFLFM 1466

  Fly  1727 TSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGL-- 1789
            .|:||||||.|:|.|||:||:..|:. ..||.|:..|.|||::|:|:......::.|..|..|
Human  1467 YSVARTNLELELIHRGGNLCSGGAST-AGKRSCLNQLFHVLALHMRLYSIDSEYNPWRKLTQLEE 1530

  Fly  1790 --PVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLC 1852
              |....|.....    :|.:..|..:|||..||:.|..|.:|:|||:|||::.|||.|.:..|.
Human  1531 MNPQLGYEEQQPE----VPILYHDVTSLLLIQILMMPQPLRKDHFTCIVKVLFTLLYTQALAALS 1591

  Fly  1853 VTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQ 1917
            |     :|                    |::..||      .:.||..::|:....|:..::||.
Human  1592 V-----KC--------------------SEEDRSA------WKHAGALKKSTCDAEKSYEVLLSF 1625

  Fly  1918 TNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPF 1982
            .          |............|:......|            .|..:.:|||..||..||||
Human  1626 V----------ISELFKGKLYHEEGTQECAMVN------------PIAWSPESMEKCLQDFCLPF 1668

  Fly  1983 LRVAALLRQHLYRHEMP--------EISAPGLEFVRLVYYLE---LVTDSMDWDCFNASKGLCFI 2036
            ||:.:||:.||:..::|        .:.|..|..:...|..|   :....:||
Human  1669 LRITSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTEHPFISASCLDW------------ 1721

  Fly  2037 PGTETTLPQF-----WCQQLMEVRPPADTVRE--LVLINQHSLWQQPRLLELPREYERLFTYYHE 2094
                 .:|.|     ||   .|::...:...|  ..|:.|.|.|:.|.||:||..|..:|.|||.
Human  1722 -----PVPAFDIITQWC---FEIKSFTERHAEQGKALLIQESKWKLPHLLQLPENYNTIFQYYHR 1778

  Fly  2095 RPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIFLVVTSTYIIVIRG 2159
            :.|..|.||||:.::||:|||.||||..||.:...||.|.|:.:||.|.||||::.::.||:|||
Human  1779 KTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRG 1843

  Fly  2160 RRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHTWVFH 2215
            .|.|||||:|||...||||||:||||||:.|:|:.:||.||:||.|.|....|..|
Human  1844 HRFCLWGSVYLDAHGEEDRDLRRGKPLYICKERYKVLEQQWISHTFDHINKRWGPH 1899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	48/66 (73%)
		FliJ	<1410..1477	CDD:280262	24/66 (36%)
UBR3	XP_005246356.1	zf-UBR	120..187	CDD:280386	48/66 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149948
Domainoid	1	1.000	936	1.000	Domainoid score	I38
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52092
Inparanoid	1	1.050	1073	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60185
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0005748
OrthoInspector	1	1.000	-	-		oto88857
orthoMCL	1	0.900	-	-		OOG6_105451
Panther	1	1.100	-	-	LDO	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3796
SonicParanoid	1	1.000	-	-		X4143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940