Protein Alignment Ubr3 and ubr1

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_002941132.3
• Gene: ubr1 / 100490039
• XenbaseID: XB-GENE-6052364
• Length: 1749
• Species: Xenopus tropicalis
• Alignment Length: 2258
• Identity: 442/2258 - (19%)
• Similarity: 726/2258 - (32%)
• Gaps: 844/2258 - (37%)

  Fly   192 LDNIEWIRWLIAGGRTPQEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKG 256
            |..:||..:    ...|..|.:.:|.......||.|:......|.||.|.|.|...:|.|||:..
 Frog    66 LTPLEWCLF----REDPNVFKEKLRHSAAPPLCGRVFRGGETTYSCRDCAIDPTCVLCMDCFQNS 126

  Fly   257 NHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDH--GINNRVNRDPVPNNLLAVAEAIMPKLLF 319
            .|.||.:.|..|..||.||||||...|...:|..|  |.:::.:...:.:.|||..:.:.| |:.
 Frog   127 IHKNHRYKMHSSMGGGFCDCGDTEAWKTGPYCKIHEPGPSDQNSDFRLKDELLAQTKIVFP-LII 190

  Fly   320 RLL----------------------------------QHFREHSDTPL---------EVQAITSY 341
            |.:                                  .|..:|....|         |.|.:||.
 Frog   191 RYIVDMLIWEEQKSLPAYLDTGTVEWNQYYCVLYNDEHHTYDHFIYSLQRSLGCDQKEAQTLTSA 255

  Fly   342 S---------------CEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFL 391
            :               |:|....|  ..|...:..|.:...:::..|.|....|.|......:.|
 Frog   256 AEREGRKAVKKGTLEQCQEVTESL--KANSENVSLKPVHVEVLHGHVMAHQSFALCLAIWLNKLL 318

  Fly   392 KAN---REKY-EDAVNRFPNPEPPDE--YRDLPALGDKLVH---TTLLEEFIFWTFKFEFPQTLV 447
            ..:   |:.: :..:.:.|.|...:.  |..|..|.|..:|   ..:|.:.||.:|..|
 Frog   319 AYSSDFRQIFCQVCLEQEPKPSSFNHTCYVSLLILKDSKLHKGVRKVLHDLIFSSFFME------ 377

  Fly   448 CFLLNMLPDQDYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNEL 512
                     .:||:.....||.||.:|..  |...|....:..|..:|||:|:..:||..::.|.
 Frog   378 ---------MEYKKQFAIEFVKHYKQIQK--EYINDDQDRNISVTAISVQVFTVPTLARLLIEEQ 431

  Fly   513 SLLHVMIISLKLMMSKILIQNTLHDPNK-NFH-------FVIDCTRQVMKDHCYWPLVSDFNNVL 569
            :::.|:..:|     ..:|:..|...|| ||.       |::            :.::.|...:|
 Frog   432 NVMKVITETL-----LEVIKEYLGSDNKFNFQGYSQERFFMV------------YAIILDLKYIL 479

  Fly   570 S------HESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHVEFEPNSYYAAFSCELEASA 628
            .      .|.:...||..   ...:..||..:|||....|....|||.: :.:.|..:.:::
 Frog   480 ISKPTSWSEKLKAKFLEG---FKSFLYFLSCMQGMEGISRMVGQHVEMD-SDWEAVIAMQMQ--- 537

  Fly   629 YPMWSIISHLQD--GTHAHLAKKIINYCVTTLHEWLDSIYFMEARL---------SMEEMMQ--- 679
              :.::::.:|:  .|...:..|....|..:|.:....:...|.:|         |...|:.
 Frog   538 --LKNVLTLIQEWCATDDDILLKSYKECHLSLLQCCTPVPSQEKKLIKMSGHSYQSYPYMVSKDP 600

  Fly   680 ASFHFPLHRYLAAFVCQAVTKMGI--SLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVRNG 742
            .|.|.||.|.||....| :.:.|:  .|.::||.....:.|::.||||......::.|..|.|||
 Frog   601 ISIHLPLSRMLAGLHAQ-MCRTGVITRLCEILPPEDLQVELMIEHPLRCLVLVGQVAAEMWRRNG 664

  Fly   743 LQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETA------PLK 801
            |.|..|...|........|.|.|:..|||.|:.|....||...::.::    ||.|      |.|
 Frog   665 LTIVSQVFYYHDVKCREEMYDKDVVMLQIGASYLDPNSFLLLLLQRYE----LEEAFSNVAVPTK 725

  Fly   802 QPQKAEQSSML-EGFLTFLATLVTSR-----TNLGNDEATQCIIEISALLATENKTHSQLLELMP 860
            ....|.|.::| |..|..|..::..|     :|:..:|.|  :.||..||..|...||.:.:.:|
 Frog   726 DMDVARQHNILIEEMLHVLICVIGERYVPGISNVTREECT--MREIIHLLCIEPMAHSAIAKALP 788

  Fly   861 ERSGNVHTKN----FETFLKKLSVYKAPS-SGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRR 920
            |      |:|    .:..:.|::.:|.|. ||     .|::    |:..::.|..:|.
 Frog   789 E------TENTDICLDKLISKVATFKKPGVSG-----HGVY----ELKAEYLDQFNVF------- 831

  Fly   921 DFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFFRAV 985
                    |.:|.|::                                     ||       :|.
 Frog   832 --------FYHYTKTQ-------------------------------------HS-------KAE 844

  Fly   986 HTR-------DVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGR 1043
            ||:       :.||.|                         ||||
 Frog   845 HTQKKRRKQENSSEAL-------------------------APPA-------------------- 864

  Fly  1044 HEPPKL--FHCYPTDNLSCN-LRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADP----E 1101
              ||..  ..|..|..|.|: :.|:::.:                      |....|.||    |
 Frog   865 --PPNFSPAFCNVTKLLCCDIMMHILRTI----------------------LKRAAEEDPIMWTE 905

  Fly  1102 QSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQD 1166
            ..::|:                                             |.::|
 Frog   906 GMIQMV---------------------------------------------LHIIA--------- 916

  Fly  1167 SNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGA 1231
                                                                             
 Frog   917 ----------------------------------------------------------------- 916

  Fly  1232 NASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSG 1296
                                  .|:|...|::|..|....
 Frog   917 ----------------------LGLLEEKQQLQRAAEEEV------------------------- 934

  Fly  1297 TGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLL--LKLHSQLSGTLDSF---------- 1349
               ..|:.....|.||.|     :|.      :|:.:||  ||..:||....|..
 Frog   935 ---TFNFYHKATRVRSTD-----ANA------QSVATLLERLKGITQLDAQKDMIIWVRQVFETV 985

  Fly  1350 -SLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGN 1413
             .|.:....:...|:..||               |.||.|:|
 Frog   986 KGLRETSSHTVPTDTVSDV---------------AKAEEGQS----------------------- 1012

  Fly  1414 LLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKK---ARERQQKMMQDFAN 1475
                                                  .:|||:|::|   ||..:||:|...:.
 Frog  1013 --------------------------------------PQEKEKRKRKAEAARLHRQKIMAQMSA 1039

  Fly  1476 KQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSG 1540
            .||.|:                |.::.||:.....:|       .|:|..||    |:...|.|.
 Frog  1040 LQKNFI----------------ETNKLLYDTTVEVQE-------STSPVEES----LLSADEGSK 1077

  Fly  1541 I-VGHRRRIAERLP-------LPINAEDESRLAHTTRLAAEFNRRTELLS------LKFGDESW- 1590
            : :|.:|  ...:|       :....|.|.:|...|.:.....:::..||      :....|::
 Frog  1078 VALGTKR--GPTVPSKDVLTCILCQEEQEVKLDKPTMVLTACVQKSTTLSQTRSKVVSHTGETFD 1140

  Fly  1591 --YLSNNMAYDNGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQ-------DRGEFYCPVCRQLS 1646
              :....|.|  |.|..||||.:|:.|.:.:.:.:....||.:.       ..||:.||:|:...
 Frog  1141 PLFTHPEMLY--GTHTGSCGHVMHVVCWQKFFEAMQKNTRQRLHVELIFDLGNGEYLCPLCKCHC 1203

  Fly  1647 NSVLPLSPQLDRPTHLV--RSGNQPFE----------RLVADLTDLIKENETI-PQPTKLTEAMG 1698
            |:|:|:.|.:.:....|  .:.|..|.          |:.....:.||..:.| |:..|:.:...
 Frog  1204 NTVIPIIPHVAQQIQSVDAEAINCVFSLPHWLDIVAARISGYNLNTIKGTKPITPEFCKIYKDQN 1268

  Fly  1699 HAM-EVMTNIAQRKVKCSSITFRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRE--CI 1760
            :.. .:::...|...:..:.|...|..|.|::.|..|..                  |..|  ..
 Frog  1269 YEFRSILSFGVQAPPRYPTCTEGMLVHFATTVYRVGLNV------------------PPNESDSR 1315

  Fly  1761 VPLL--HVLSVHVRVLVEW------PLWSSWAS--LAGLP----------VTATEP--------- 1796
            :|::  :..:..::.:..|      ||:.|..:  ||||.          ||..:|
 Frog  1316 MPVMTWNTCAFTIQCIESWLQDEEKPLFGSLQNRQLAGLQALVKFAEAQRVTCPQPLIRRHLIRL 1380

  Fly  1797 ----LPAHCLELIPSILA-DPIALLLKFILLAP-LQLDQD---YFTCMVKVMYNLLYYQIVVQLC 1852
                ||...||..||.|: |...||:..:|..| |..:::   :.:.:|....||..:.:
 Frog  1381 LAAFLPNITLEDTPSFLSLDVFHLLVGSVLAFPSLYCEENVDLHPSTLVSTYNNLYLFHL----- 1440

  Fly  1853 VTLTDLECDHIVKVYGSTSVGSDN-SAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLS 1916
            :|:|     ||:::.  .|:.:|| .:.|....|.|       |.|....|..|||
 Frog  1441 LTMT-----HILQII--FSLTTDNVPSTEPDDCEEA-------RTAATLCQDISQL--------- 1482

  Fly  1917 QTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLP 1981
                           ||:|......|.........|                          .:|
 Frog  1483 ---------------TSNSLKIDFPGWYVWKCVKEG--------------------------IMP 1506

  Fly  1982 FLRVAALLRQHLYRHEMP-EISAPGL---EFVRLVYYLELVTDSM-----DWDCFNASKGLCFIP 2037
            :||.|||...:|.....| |:.:.|.   :...|..:|.|.|:.:     :||..
 Frog  1507 YLRCAALFFHYLLGVMPPEELKSSGTTDNQLSALCSFLCLPTNILLLFQENWDIV---------- 1561

  Fly  2038 GTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQPR----LLELPREYERLFTYYHERPCL 2098
                        :|:..|..:|...:.||....:..:.||    |:|||.:|..|.....:..|.
 Frog  1562 ------------KLLIQRLSSDQSLQSVLAGYTTALRYPRKRNTLIELPEDYSSLLNQASQFRCP 1614

  Fly  2099 NCYKVPKESSI-CLLCGTIVCLKQNCC------AENDCCEAVRHTLSCGGGIGIFLVVTSTYIIV 2156
            ......::..: |||||.|:|.:..||      .|...|.|  |.:.||.|:.|||.:....:::
 Frog  1615 KFQDAERKHPVMCLLCGAILCSQNTCCQEVVNGEELGACTA--HAMHCGAGVCIFLSIRECKVVL 1677

  Fly  2157 IRGR-RACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSH 2203
            :.|: |.|::.:.|||::.|.|..||||.||:||.:|:..|...|..|
 Frog  1678 MEGKTRGCIYQAPYLDEYGETDPGLKRGNPLHLSHERYRKLHQLWQQH 1725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	29/69 (42%)
		FliJ	<1410..1477	CDD:426581	10/69 (14%)
		RING-H2_UBR3	1601..1651	CDD:438146	17/56 (30%)
		PRT6_C	1722..2202	CDD:465944	124/541 (23%)
ubr1	XP_002941132.3	UBR-box_UBR1	93..163	CDD:439076	29/69 (42%)
		ClpS	217..>274	CDD:460621	8/56 (14%)
		RING-H2_UBR1	1092..1211	CDD:438346	27/120 (23%)
		PRT6_C	1296..1724	CDD:465944	123/538 (23%)