DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10778 and Nus1

DIOPT Version :9

Sequence 1:	NP_001259316.1	Gene:	CG10778 / 31708	FlyBaseID:	FBgn0029980	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_084526.1	Gene:	Nus1 / 52014	MGIID:	1196365	Length:	297	Species:	Mus musculus

Alignment Length:	245	Identity:	50/245 - (20%)
Similarity:	97/245 - (39%)	Gaps:	55/245 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WTERIAMRTLRACGYIPHHVAFVMDGNRRFARSQQIDKIEGHSRGFEKLADCLRWCLDVGVREVT 75
            |  |..:|:|:.   :|.|:..::        ::::.:     ..|..:|..:.||:.||:..::
Mouse    91 W--RADVRSLQK---LPVHMGLLV--------TEEVQE-----PSFSDIASLVVWCMAVGISYIS 137

  Fly    76 TFAFSIENFKRSNEEVEGLFNLAREKFARLLEETARLDEHGIRIRVIGNIELLPHDLQKLVASAM 140
            .:... ..|||:|              :||::|..:..:           |||..|..|..|...
Mouse   138 VYDHQ-GIFKRNN--------------SRLMDEILKQQQ-----------ELLGQDCSKYSAEFA 176

  Fly   141 LSTERNDKLFLNVAFAY------TSRDEITQAVETILR-HGSQDLAGEDISERLLEECLYTRHSP 198
            .|.:::|: .||...|.      ..:.:|.:|.:...: ...|.....|:...||...|.:...|
Mouse   177 NSNDKDDQ-DLNCPSAVKVLSPEDGKADIVRAAQDFCQLVAQQQRKPTDLDVDLLGSLLSSHGFP 240

  Fly   199 PPDLVFRTSGETRLSDFMMWQLS-TSVLYFSNVLWPQITFWHFLASILAY 247
            .||||.:.........|:.||:. |.::...:.|  .|::..|.:::..|
Mouse   241 DPDLVLKFGPVDSTLGFLPWQIRLTEIVSLPSHL--NISYEDFFSALRQY 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10778	NP_001259316.1	Cis_IPPS	29..249	CDD:259850	45/227 (20%)
Nus1	NP_084526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..86
		UppS	<124..297	CDD:223099	42/194 (22%)
		RXG motif, crucial for prenyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q96E22	294..296
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810