DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx50

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_444413.1	Gene:	Ddx50 / 94213	MGIID:	2182303	Length:	734	Species:	Mus musculus

Alignment Length:	504	Identity:	153/504 - (30%)
Similarity:	249/504 - (49%)	Gaps:	68/504 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EERAEIQREKAKNPGRNLVKPKWENLEP-----------FLKDFYNIHPNTLAKSEQQ------V 216
            |||.| .||.......:..|||...:..           |..:|...|     ||.::      |
Mouse    42 EERTE-TRENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPSH-----KSRRKDLPNGDV 100

  Fly   217 AEIRRELEITVSGNELPHPVV--------------SFEESSLPAHVIEEMKRQGFTKPTAIQSQG 267
            .|..:..: .||.:|..|...              :|...|:....|:.:|.:|.|....||.:.
Mouse   101 DEYEKRSK-RVSSSENSHKSSDKAEETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKT 164

  Fly   268 WPIALSGRDLVGIAQTGSGKTLAYMLPAIVHI-GNQPPIIRGEGPIALVLAPTRELAQQIQSVVR 331
            :.....|:||:..|:||:|||.::.:|.|..: .||..|.:...|..||||||||||.|   |.:
Mouse   165 FGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQ---VAK 226

  Fly   332 DYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEAD 396
            |:..:.: ::...|.:||:|...|...:..|:::::.||||:.|.|::...:|.:..::||||.|
Mouse   227 DFKDITR-KLSVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVD 290

  Fly   397 RMLDMGFEPQIRKII-EQIRPDR----QVVMWSATWPKEVQALAGDFLND-YIQIN-IGSMNLSA 454
            :|||:||..|:..|| |..:.|.    |.:::|||.|:.|..:|..::.. |.|:: :|.|...|
Mouse   291 QMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKA 355

  Fly   455 NHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNAT 519
            ...:..:...|...::|    .::.::..: .||:.| :.|:|.|||..|.::......: .||.
Mouse   356 ATTVEHLAIQCHWSQRP----AVIGDVLQV-YSGSEG-RAIIFCETKKNVTEMAMNPHIK-QNAQ 413

  Fly   520 SIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGR 584
            .:|||..|::|:..||.||.|...:|:||:||:||||:.::..||....|...|:|:||.|||||
Mouse   414 CLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGR 478

  Fly   585 CQQLGTAYTFFTPDNAKQARELISVLEEAGQT------PSQALLDLARS 627
            ..:.|....|:.|   ::..:|..|.::||.|      ||  .:||.:|
Mouse   479 AGRTGICVCFYQP---RERGQLRYVEQKAGITFKRVGVPS--TMDLVKS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	153/504 (30%)
		DEADc	239..446	CDD:238167	73/213 (34%)
		HELICc	457..594	CDD:238034	45/136 (33%)
Ddx50	NP_444413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		20/95 (21%)
		SrmB	130..608	CDD:223587	133/409 (33%)
		Q motif	134..162		7/27 (26%)
		DEADc	136..339	CDD:238167	71/206 (34%)
		DEVD box	287..290		2/2 (100%)
		HELICc	369..486	CDD:238034	44/123 (36%)
		GUCT_RHII_Gualpha_beta	565..656	CDD:240593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..734
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820