DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and TDRD12

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_011525773.1	Gene:	TDRD12 / 91646	HGNCID:	25044	Length:	1335	Species:	Homo sapiens

Alignment Length:	496	Identity:	114/496 - (22%)
Similarity:	213/496 - (42%)	Gaps:	58/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 AAALGMLSKEERAEIQREKAKNPGRNLVKPKWENLEPFLKDFYNIHPNTL----AKSEQQVAEIR 220
            |:||...|.|:...:..:|..:...:.||         |..|.|  |:.|    ....||:.:::
Human   346 ASALSQKSNEKPLRLTEKKEYDEKNSCVK---------LLQFLN--PDPLRADGISDLQQLQKLK 399

  Fly   221 -RELEITVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTG 284
             .:..:.|..|:: .|.::.:.|.|.|.:.:.::|..|..|:..:|..||....|.|:|.|:...
Human   400 GLQPPVVVLRNKI-KPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCE 463

  Fly   285 SGKTLAYMLPAIVHIGN---QPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCI 346
            | ..|.|:||.:..:..   ...:....||:|:::.|..:.||.|..::.:|....:|.......
Human   464 S-NPLLYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLT 527

  Fly   347 FGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKII 411
            .|...:..:...|.||.:||:.||..|:..|..::....|..:|:|||.: :|.:....|:..|:
Human   528 IGLHKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFLRLCHLILDEVE-VLFLEANEQMFAIL 591

  Fly   412 EQIRPD----------RQVVMWSATWPKEVQALAGDFLND-YIQINIGSMNLSANH-NIRQIVEI 464
            :..:.:          .|:|.....|.|.::.|..:|:|| ||.|.  :|..:|.: |::|:|.:
Human   592 DNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVIT--AMEEAALYGNVQQVVHL 654

  Fly   465 CTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGD---KT 526
            |.|.||...|:..|:.|.      :...|.::|..:..:.|.:.:::.:.......:|.:   ..
Human   655 CLECEKTSSLLQALDFIP------SQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNL 713

  Fly   527 QNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRI--------GRTG 583
            ||..:...|...:|...||..||.....|.:.|...||::.:|.|.:.:..|:        ...|
Human   714 QNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQG 778

  Fly   584 RCQQLG----TAYTFFTPDNAKQARELISVLEEA-GQTPSQ 619
            ...:.|    .:....|..:|..|..::..||.| .:.|::
Human   779 SPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAE 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	114/496 (23%)
		DEADc	239..446	CDD:238167	55/220 (25%)
		HELICc	457..594	CDD:238034	31/151 (21%)
TDRD12	XP_011525773.1	TUDOR	10..128	CDD:278965
		TUDOR	60..109	CDD:119391
		P-loop_NTPase	419..635	CDD:304359	54/217 (25%)
		SrmB	422..881	CDD:223587	95/408 (23%)
		P-loop_NTPase	659..762	CDD:304359	23/108 (21%)
		TUDOR	<913..1004	CDD:278965
		alpha-crystallin-Hsps_p23-like	1193..1297	CDD:294116
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810