Protein Alignment mahe and DDX59

DIOPT Version :10

• Sequence 1: NP_572424.1
• Gene: mahe / 31707
• FlyBaseID: FBgn0029979
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001026895.2
• Gene: DDX59 / 83479
• HGNCID: 25360
• Length: 619
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 170/512 - (33%)
• Similarity: 265/512 - (51%)
• Gaps: 49/512 - (9%)

  Fly   132 KNPTYAQRYQKPNNGAGVAGGYQSN-----------NYNAAALGMLSKEERAEIQREKAKNPGRN 185
            |:.:..||:.:|.....|..|....           :....|..:|..:|:.|  :.|..||.:.
Human    92 KSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEE--KSKLSNPQKA 154

  Fly   186 LVKPKWENLEPFLKDF-YNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVI 249
            ..:|:    .|....: |..||..|...|.|:..::::|.|.|.|.|:..|::.||..|||..:.
Human   155 DSEPE----SPLNASYVYKEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLN 215

  Fly   250 EEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEGPIAL 314
            ..:|:.|:..||.||.|..|:.|.|||::..|.||||||.|::||.|:.     .:...:.|.||
Human   216 HNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR-----ALFESKTPSAL 275

  Fly   315 VLAPTRELAQQIQSVVRDY--GHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFL 377
            :|.||||||.||:...::.  |   .|.::...:.||....||...|.:.|:|||||||||:|.:
Human   276 ILTPTRELAIQIERQAKELMSG---LPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDII 337

  Fly   378 ENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDY 442
            :..:..|.....:|:||||.||.|||:.|:..|:|.|..|.|.::.|||.|..::.||...|::.
Human   338 KQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNP 402

  Fly   443 IQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDI 507
            ::|..|..||.. .|:|||:....:..|.::|..:||:....|      ..::|||:.|:..:.:
Human   403 VRIITGEKNLPC-ANVRQIILWVEDPAKKKKLFEILNDKKLFK------PPVLVFVDCKLGADLL 460

  Fly   508 LQII-RAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNS 571
            .:.: :..|..:.|||.:|:|.||.::||....|...::::|.|..||||:..::.|:|:|.|:|
Human   461 SEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSS 525

  Fly   572 SENYVHRIGRTGRCQQLGTAYTFFTP-------DNAKQARELISVLEEAGQTPSQAL 621
            .:.|||:|||.||..|.|||.||...       |.||:.:...|:|      |.|.|
Human   526 MDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRVKPTGSIL------PPQLL 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_572424.1	DEAD-like_helicase_N	136..656	CDD:475120	169/508 (33%)
DDX59	NP_001026895.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..98		1/5 (20%)
		PLN00206	89..592	CDD:215103	170/512 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..161		5/24 (21%)
		Q motif	203..231		10/27 (37%)
		DEAD box	353..356		2/2 (100%)