DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and DDX59

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001026895.2	Gene:	DDX59 / 83479	HGNCID:	25360	Length:	619	Species:	Homo sapiens

Alignment Length:	512	Identity:	170/512 - (33%)
Similarity:	265/512 - (51%)	Gaps:	49/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 KNPTYAQRYQKPNNGAGVAGGYQSN-----------NYNAAALGMLSKEERAEIQREKAKNPGRN 185
            |:.:..||:.:|.....|..|....           :....|..:|..:|:.|  :.|..||.:.
Human    92 KSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEE--KSKLSNPQKA 154

  Fly   186 LVKPKWENLEPFLKDF-YNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVI 249
            ..:|:    .|....: |..||..|...|.|:..::::|.|.|.|.|:..|::.||..|||..:.
Human   155 DSEPE----SPLNASYVYKEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLN 215

  Fly   250 EEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEGPIAL 314
            ..:|:.|:..||.||.|..|:.|.|||::..|.||||||.|::||.|:.     .:...:.|.||
Human   216 HNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR-----ALFESKTPSAL 275

  Fly   315 VLAPTRELAQQIQSVVRDY--GHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFL 377
            :|.||||||.||:...::.  |   .|.::...:.||....||...|.:.|:|||||||||:|.:
Human   276 ILTPTRELAIQIERQAKELMSG---LPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDII 337

  Fly   378 ENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDY 442
            :..:..|.....:|:||||.||.|||:.|:..|:|.|..|.|.::.|||.|..::.||...|::.
Human   338 KQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNP 402

  Fly   443 IQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDI 507
            ::|..|..||.. .|:|||:....:..|.::|..:||:....|      ..::|||:.|:..:.:
Human   403 VRIITGEKNLPC-ANVRQIILWVEDPAKKKKLFEILNDKKLFK------PPVLVFVDCKLGADLL 460

  Fly   508 LQII-RAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNS 571
            .:.: :..|..:.|||.:|:|.||.::||....|...::::|.|..||||:..::.|:|:|.|:|
Human   461 SEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSS 525

  Fly   572 SENYVHRIGRTGRCQQLGTAYTFFTP-------DNAKQARELISVLEEAGQTPSQAL 621
            .:.|||:|||.||..|.|||.||...       |.||:.:...|:|      |.|.|
Human   526 MDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRVKPTGSIL------PPQLL 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	169/508 (33%)
		DEADc	239..446	CDD:238167	82/208 (39%)
		HELICc	457..594	CDD:238034	47/137 (34%)
DDX59	NP_001026895.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..98		1/5 (20%)
		DEXDc	89..592	CDD:331760	170/512 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		5/24 (21%)
		Q motif	203..231		10/27 (37%)
		DEAD box	353..356		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810