DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and DDX50

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_076950.1	Gene:	DDX50 / 79009	HGNCID:	17906	Length:	737	Species:	Homo sapiens

Alignment Length:	665	Identity:	173/665 - (26%)
Similarity:	295/665 - (44%)	Gaps:	151/665 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVV------SFEESSLPAHVIEEMKRQGF 257
            ||..|...:...|..::|:.:......: |.|:|...:.      :|....:....|:.:|.:|.
Human    94 KDLPNGDIDEYEKKSKRVSSLDTSTHKS-SDNKLEETLTREQKEGAFSNFPISEETIKLLKGRGV 157

  Fly   258 TKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHI-GNQPPIIRGEGPIALVLAPTRE 321
            |....||.:.:.....|:||:..|:||:|||.::.:|.|..: .||..|.:...|..||||||||
Human   158 TYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRE 222

  Fly   322 LAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQR 386
            ||.|   |.:|:..:.: ::...|.:||:|...|...:..|:::::.||||:.|.|::...:|.:
Human   223 LANQ---VAKDFKDITR-KLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSK 283

  Fly   387 CTYLVLDEADRMLDMGFEPQIRKII-EQIRPDR----QVVMWSATWPKEVQALAGDFLND-YIQI 445
            ..::||||.|:|||:||..|:..|| |..:.|.    |.:::|||.|:.|..:|..::.. |.|:
Human   284 LRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQV 348

  Fly   446 N-IGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQ 509
            : :|.|...|...:..:...|...::|    .::.::..: .||:.| :.|:|.|||..|.::..
Human   349 DLVGKMTQKAATTVEHLAIQCHWSQRP----AVIGDVLQV-YSGSEG-RAIIFCETKKNVTEMAM 407

  Fly   510 IIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSEN 574
            ....: .||..:|||..|::|:..||.||.|...:|:||:||:||||:.::..||....|...|:
Human   408 NPHIK-QNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVES 471

  Fly   575 YVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQT------PS------QALLDLARS 627
            |:||.|||||..:.|....|:.|   ::..:|..|.::||.|      ||      ...:|..||
Human   472 YIHRSGRTGRAGRTGICICFYQP---RERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRS 533

  Fly   628 MPS---------------------------------SGGY-----------RG------------ 636
            :.|                                 ||..           :|
Human   534 LASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESLEEI 598

  Fly   637 ----------NKRWNNNSGGDRN----TGGNNGI-------------YQQRNNNPL--------- 665
                      |::.::|:.....    ..||.|:             .:..:::.:
Human   599 QDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPE 663

  Fly   666 --NYQAGNNYNNN--RSGPPTGSSYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQ--QQR 724
              .|..||..:|:  |||..:|.|.:...:||    ::|...|    |.::.|...|:.|  ::|
Human   664 IEEYYDGNTSSNSRQRSGWSSGRSGRSGRSGG----RSGGRSG----RQSRQGSRSGSRQDGRRR 720

  Fly   725 NGNTYRPRAPFNNGG 739
            :||..|.|    :||
Human   721 SGNRNRSR----SGG 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	148/552 (27%)
		DEADc	239..446	CDD:238167	72/213 (34%)
		HELICc	457..594	CDD:238034	45/136 (33%)
DDX50	NP_076950.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		8/37 (22%)
		SrmB	108..526	CDD:223587	133/432 (31%)
		Q motif	137..165		6/27 (22%)
		DEADc_DDX21_DDX50	148..349	CDD:350702	71/204 (35%)
		DEVD box	290..293		2/2 (100%)
		GUCT_RHII_Gualpha_beta	568..659	CDD:240593	8/90 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..737		23/76 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820