DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx23

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001074450.1	Gene:	Ddx23 / 74351	MGIID:	1921601	Length:	819	Species:	Mus musculus

Alignment Length:	528	Identity:	192/528 - (36%)
Similarity:	288/528 - (54%)	Gaps:	75/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 NPTYAQRYQKPNNGAGVAGGY---QSNNYNAAALGMLSKEERAEIQREKAKNPGRNL----VKPK 190
            ||.|.:|:|....|.|...|.   |.....:...|.|.::.|...::|:.:...|.|    .|.:
Mouse   286 NPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQR 350

  Fly   191 WENLEPFLKDFYNIHPNTLAKSEQQVAEI--------RRELEITVSGNELPHPVVSFEESSLPAH 247
            |::..               .|::::.|:        |.:..||..|.::|:|:.|:::||||.|
Mouse   351 WDDRH---------------WSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPH 400

  Fly   248 VIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIR----G 308
            ::|.:.:.|:.:||.||.|..||.|..||::|:|:||||||.|:::|.:|.|...|.|.|    .
Mouse   401 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESD 465

  Fly   309 EGPIALVLAPTRELAQQIQSVVRDYGHLCKP-EIRHTCIFGGSSKVPQARDLDRGVEVIIATPGR 372
            :||.|::|||||||||||:.....:|   || .||...:.||.|:..|...|..|.|::||||||
Mouse   466 QGPYAIILAPTRELAQQIEEETIKFG---KPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGR 527

  Fly   373 LIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQI-----RPD--------------- 417
            |||.||||...|.||||:||||||||:||||||.::||:|.:     :||
Mouse   528 LIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFE 592

  Fly   418 ------RQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVC 476
                  ||.||::||.|..|:.||..:|.....:.|||.. ..:..:.|.|.:.:|.||.::|:.
Mouse   593 SGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAG-KPHERVEQKVFLMSESEKRKKLLA 656

  Fly   477 LLNE-ISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNG 540
            :|.: ..|         .||:||..|...:.:.:.:...||||.::||.|.|.:|:..|.:.:.|
Mouse   657 ILEQGFDP---------PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAG 712

  Fly   541 KSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARE 605
            ..:||:|||||.||:|::|:..|:|||...:.|:|:||||||||..:.|.|.||.|.:::....|
Mouse   713 AKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYE 777

  Fly   606 LISVLEEA 613
            |...:.|:
Mouse   778 LKQAILES 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	190/525 (36%)
		DEADc	239..446	CDD:238167	106/237 (45%)
		HELICc	457..594	CDD:238034	51/137 (37%)
Ddx23	NP_001074450.1	SF-CC1	79..>207	CDD:273721
		DUF5401	<163..350	CDD:375164	16/63 (25%)
		DEADc_DDX23	401..627	CDD:350703	101/228 (44%)
		SF2_C_DEAD	638..767	CDD:350174	52/137 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920