DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx17

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_951062.1	Gene:	Ddx17 / 67040	MGIID:	1914290	Length:	652	Species:	Mus musculus

Alignment Length:	707	Identity:	338/707 - (47%)
Similarity:	422/707 - (59%)	Gaps:	94/707 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GGYGGQRGKNPTYAQRYQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPGRNLVK 188
            ||..|.|.::        :...|.|..||                   :.:..:|..|||..|.|
Mouse     3 GGGFGDRDRD--------RDRGGFGARGG-------------------SGLPPKKFGNPGERLRK 40

  Fly   189 PKWE--NLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNEL-PHPVVSFEESSLPAHVIE 250
            .||:  .|..|.|:||..||.....:..:|.|:||:.||||.|.:: |.||.:|..::.|.:|::
Mouse    41 KKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMD 105

  Fly   251 EMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEGPIALV 315
            .:..|.||:||.||.||:|:||||||:||||||||||||||:|||||||.:||.:.||:|||.||
Mouse   106 VLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLV 170

  Fly   316 LAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENR 380
            ||||||||||:|.|..|||...:  ::.|||:||:.|.||.|||:||||:.||||||||||||:.
Mouse   171 LAPTRELAQQVQQVADDYGKCSR--LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESG 233

  Fly   381 NTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQI 445
            .|||:|||||||||||||||||||||||||::|||||||.:||||||||||:.||.|||.||.||
Mouse   234 KTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQI 298

  Fly   446 NIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQI 510
            |:|::.|||||||.|||::|.|.||..:|:.|:.||...|.     ||.|:|||||.:.:|:.:.
Mouse   299 NVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKE-----NKTIIFVETKRRCDDLTRR 358

  Fly   511 IRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENY 575
            :|.:|:.|..|||||:|.|||.||.:||:||:.||||||||||||||||:::|||||||||||:|
Mouse   359 MRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDY 423

  Fly   576 VHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLA--RSMPSSGGYRGNK 638
            |||||||.|....|||||||||.|.|||||||.|||||.|..:..|:.|.  |.....||..|..
Mouse   424 VHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRS 488

  Fly   639 RWNNNSGG-----------DRNTGG-------NNGIYQQRN-NNPLNYQAGNNYNNNRSGPPTGS 684
            |:...|..           ||...|       ::..|:.|: .:..:|..|:.|     |.|..:
Mouse   489 RYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSTSYRDRSETDRASYANGSGY-----GSPNSA 548

  Fly   685 SYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQQQRNGNTYRPRAPFNNGGPRAIMGHQGG 749
            ...|  ||..||.| |..|...:.......|:..||       ||...:..:.|........|..
Mouse   549 FGAQ--AGQYTYAQ-GTYGAAAYGTSGYTAQEYAAG-------TYGASSTASAGRSSQSSSQQFS 603

  Fly   750 GVGAGGAAGVGGGPQQLMAPQQGGQYMPQAYRGRSQFVPQGAG--AGGMPPRFQQYP 804
            |:|..|..     ||.||: ||..|             |.||.  .|.|.....|||
Mouse   604 GIGRSGQQ-----PQPLMS-QQFAQ-------------PPGATNMIGYMGQTAYQYP 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	294/542 (54%)
		DEADc	239..446	CDD:238167	144/206 (70%)
		HELICc	457..594	CDD:238034	81/136 (60%)
Ddx17	NP_951062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		12/61 (20%)
		DEXDc	32..502	CDD:331760	286/476 (60%)
		Q motif	92..120		9/27 (33%)
		DEAD box	246..249		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..652		20/76 (26%)
		Interaction with YAP1. /evidence=ECO:0000250\|UniProtKB:Q92841	641..649		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10604
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730