DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and ddx59

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001038443.2	Gene:	ddx59 / 562123	ZFINID:	ZDB-GENE-050208-665	Length:	584	Species:	Danio rerio

Alignment Length:	422	Identity:	143/422 - (33%)
Similarity:	231/422 - (54%)	Gaps:	31/422 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRD 276
            :|:|:..::.||.|...|.|:..||:.|:....|..:.:.:|..|:..||.:|.|..|:.|:|||
Zfish   145 TEEQIERVKAELGIVSVGTEVCRPVIEFQHCRFPTVLEKNLKVAGYEAPTPVQMQMVPVGLTGRD 209

  Fly   277 LVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG-----PIALVLAPTRELAQQIQSVVRDYGHL 336
            ::..|.||||||:|::||.::.      .::.|.     |..|:|.||||||.||:...::   |
Zfish   210 VIATADTGSGKTVAFLLPVVMR------ALQSESASPSCPACLILTPTRELAIQIEEQAKE---L 265

  Fly   337 CK--PEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRML 399
            .:  |.:|...:.||....||...|...::::|.|||||::.|:.:...|.....:|:||||.||
Zfish   266 MRGLPNMRTALLVGGMPLPPQLHRLKHNIKIVIGTPGRLLEILKQKAIQLDHVRTVVVDEADTML 330

  Fly   400 DMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEI 464
            .|||:.|:..|:||:..|.|.::.|||.|...|.||....:|.:.|.||..|... .|:||||..
Zfish   331 KMGFQQQVLDILEQVPEDHQTLLTSATIPTGTQQLAERLTHDPVTITIGQKNQPC-ANVRQIVLW 394

  Fly   465 CTEIEKPQRLVCLLNE---ISPIKNSGNNGNKIIVFVETKIKVEDILQII-RAEGYNATSIHGDK 525
            ..|..|.::|..:||:   ..|         .::|||:.|:..:.:.:.: :....|..:||.||
Zfish   395 VEEPSKKKKLFEILNDEKLYQP---------PVVVFVDCKLGADLLCEAVQKVMSLNTVAIHSDK 450

  Fly   526 TQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGT 590
            .|.||:.::|....|:.:::|:|.:..||||:.:::.|||:|.|::.:.|||:|||.||....||
Zfish   451 MQWERNKIVKGLLEGQFDVVISTGILGRGLDLVNVKLVINFDMPSNMDEYVHQIGRAGRLGHRGT 515

  Fly   591 AYTFFTPDNAKQARELISVLEEAGQ-TPSQAL 621
            |.||...:|.:...|::..::..|. .|.|.|
Zfish   516 AITFMNNNNKRLFLEMVKRVKPTGSILPPQIL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	143/422 (34%)
		DEADc	239..446	CDD:238167	75/213 (35%)
		HELICc	457..594	CDD:238034	47/140 (34%)
ddx59	NP_001038443.2	PLN00206	60..562	CDD:215103	143/422 (34%)
		zf-HIT	75..102	CDD:282314
		DEADc	183..377	CDD:238167	73/202 (36%)
		HELICc	387..519	CDD:238034	47/140 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810