DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and CG7878

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	245/704 - (34%)
Similarity:	357/704 - (50%)	Gaps:	140/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GGSGNGAPRHERQYY------PRGNFG--------GAAGGAGINGAATAAGSMHFGQPYGVMTYG 81
            ||.|.|. |.:|..|      .|.|:|        .|.||.|....:.:..|...|:
  Fly    49 GGEGRGY-RAKRNDYGGGRRDNRDNYGAGHRDSRDSAGGGGGDFSESLSIASEMVGK-------- 104

  Fly    82 IQNGLGMGAAGSGGGNPYRQQNG-------------VAFAGN--------------------GLG 113
                    ..|.||.|..|.||.             |...|:                    ..|
  Fly   105 --------VIGRGGSNISRIQNDFNVRVKLDKCDLIVKITGSIQSNVIDAINHVRKQVTNSGDRG 161

  Fly   114 GGAGGGSGGS------GGYGGQRGK----NPTYAQRYQKPNNGAGVAGGYQSNNYNAAALGMLSK 168
            ........||      |||...:|.    |||.:                :||..|....|::..
  Fly   162 QDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSS----------------ESNKDNGDLTGIIDW 210

  Fly   169 E--ERAEIQREKAKNPGRNLVKPKWENLEPFLKDFYNIHPNTLAKSEQQVAEIRRE-LEITVS-- 228
            |  .:|.|....|          :|....|..|:||...|.....::.::..||.| .:||||
  Fly   211 EALNKASIAATAA----------RWSKCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYV 265

  Fly   229 --------GNELPHPVVSFEE--SSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQT 283
                    ...:|:||.:||:  :..| .::||:.:.||:||:.||||.|||.|.|.|::|||||
  Fly   266 FEPKEGETSPPIPNPVWTFEQCFAEYP-DMLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQT 329

  Fly   284 GSGKTLAYMLPAIVHIGNQ--PPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCI 346
            |:|||||::||.::|...|  |...|| |...||||||||||.||:..|:.|..   ..::..|:
  Fly   330 GTGKTLAFLLPGMIHTEYQSTPRGTRG-GANVLVLAPTRELALQIEMEVKKYSF---RGMKAVCV 390

  Fly   347 FGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKII 411
            :||.::..|..||:||.|:||.|||||.|.:.....::...||||||||||||||||||||||::
  Fly   391 YGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVM 455

  Fly   412 EQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEIC-TEIEKPQRLV 475
            ..||||||.:|.|||||..|:.||..::.:.||:.:||::|:|.|:::||:::. .:::|
  Fly   456 LDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDMDK----- 515

  Fly   476 CLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNG 540
              .|.|:....:.::.:|||:|...|::.:|:...:..:|:....|||::.|.:|:..:.|.::|
  Fly   516 --FNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSG 578

  Fly   541 KSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARE 605
            ...||:||||||||||:||:.:|||||:|::.|.||||:|||||..:.||:.:|||.::...|:|
  Fly   579 VVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKE 643

  Fly   606 LISVLEEAGQTPSQALLDLARSMPS--------SGGY--RGNKRWNNNSGGDRN 649
            ||.:|:||.|.....|.::||...:        .||:  ||.:......||.||
  Fly   644 LIEILQEAEQEVPDELHNMARRFKAMKDKRAAEGGGFGGRGGRFGGGRGGGRRN 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	210/542 (39%)
		DEADc	239..446	CDD:238167	108/210 (51%)
		HELICc	457..594	CDD:238034	51/137 (37%)
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	11/73 (15%)
		DEADc	288..489	CDD:238167	105/205 (51%)
		DEXDc	298..505	CDD:214692	108/210 (51%)
		Helicase_C	514..624	CDD:278689	47/116 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451493
Domainoid	1	1.000	152	1.000	Domainoid score	I185
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		mtm9750
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890